Safety and Immunogenicity of an Anti–Zika Virus DNA Vaccine

There are no known specific therapies or vaccines to treat or prevent Zika virus infection. In this report, encouraging data are presented from a phase 1 study of a DNA vaccine against ZIKV infection.

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Bibliographic Details
Published in:The New England journal of medicine Vol. 385; no. 12; p. e35
Main Authors: Tebas, Pablo, Roberts, Christine C, Muthumani, Kar, Reuschel, Emma L, Kudchodkar, Sagar B, Zaidi, Faraz I, White, Scott, Khan, Amir S, Racine, Trina, Choi, Hyeree, Boyer, Jean, Park, Young K, Trottier, Sylvie, Remigio, Celine, Krieger, Diane, Spruill, Susan E, Bagarazzi, Mark, Kobinger, Gary P, Weiner, David B, Maslow, Joel N
Format: Journal Article
Language:English
Published: United States Massachusetts Medical Society 16.09.2021
Subjects:
Adult
Adverse events
Animals
Antibodies
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Clinical trials
Confidence intervals
Congenital defects
Dengue fever
Deoxyribonucleic acid
DNA
DNA vaccines
DNA viruses
Electroporation
Enzyme-linked immunosorbent assay
Enzymes
FDA approval
Female
Global Health
Guillain-Barre syndrome
Humans
Immune response
Immunization
Immunogenicity
Immunogenicity, Vaccine
Infections
Infectious Disease
Injection
Injections, Intradermal - adverse effects
Laboratories
Lethal dose
Life sciences
Male
Mice
Mice, Knockout
Middle Aged
Nucleotide sequence
Peptides
Safety
T-Lymphocytes - physiology
Vaccines
Vaccines, DNA - administration & dosage
Vaccines, DNA - adverse effects
Vaccines, DNA - immunology
Viral Infections
Viral Vaccines - immunology
Zika virus
Zika Virus - immunology
Zika Virus Infection - immunology
Zika Virus Infection - prevention & control
α-Interferon
β-Interferon
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Description
Summary:There are no known specific therapies or vaccines to treat or prevent Zika virus infection. In this report, encouraging data are presented from a phase 1 study of a DNA vaccine against ZIKV infection.
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1708120