Safety and Immunogenicity of an Anti–Zika Virus DNA Vaccine

There are no known specific therapies or vaccines to treat or prevent Zika virus infection. In this report, encouraging data are presented from a phase 1 study of a DNA vaccine against ZIKV infection.

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Vydáno v:The New England journal of medicine Ročník 385; číslo 12; s. e35
Hlavní autoři: Tebas, Pablo, Roberts, Christine C, Muthumani, Kar, Reuschel, Emma L, Kudchodkar, Sagar B, Zaidi, Faraz I, White, Scott, Khan, Amir S, Racine, Trina, Choi, Hyeree, Boyer, Jean, Park, Young K, Trottier, Sylvie, Remigio, Celine, Krieger, Diane, Spruill, Susan E, Bagarazzi, Mark, Kobinger, Gary P, Weiner, David B, Maslow, Joel N
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Massachusetts Medical Society 16.09.2021
Témata:
Adult
Adverse events
Animals
Antibodies
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Clinical trials
Confidence intervals
Congenital defects
Dengue fever
Deoxyribonucleic acid
DNA
DNA vaccines
DNA viruses
Electroporation
Enzyme-linked immunosorbent assay
Enzymes
FDA approval
Female
Global Health
Guillain-Barre syndrome
Humans
Immune response
Immunization
Immunogenicity
Immunogenicity, Vaccine
Infections
Infectious Disease
Injection
Injections, Intradermal - adverse effects
Laboratories
Lethal dose
Life sciences
Male
Mice
Mice, Knockout
Middle Aged
Nucleotide sequence
Peptides
Safety
T-Lymphocytes - physiology
Vaccines
Vaccines, DNA - administration & dosage
Vaccines, DNA - adverse effects
Vaccines, DNA - immunology
Viral Infections
Viral Vaccines - immunology
Zika virus
Zika Virus - immunology
Zika Virus Infection - immunology
Zika Virus Infection - prevention & control
α-Interferon
β-Interferon
ISSN:0028-4793, 1533-4406, 1533-4406
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Popis
Shrnutí:There are no known specific therapies or vaccines to treat or prevent Zika virus infection. In this report, encouraging data are presented from a phase 1 study of a DNA vaccine against ZIKV infection.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1708120