Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages

Bisphosphonates drugs target the skeleton and are used globally for the treatment of common bone disorders. Nitrogen-containing bisphosphonates act by inhibiting the mevalonate pathway in bone-resorbing osteoclasts but, surprisingly, also appear to reduce the risk of death from pneumonia. We overtur...

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Bibliographic Details
Published in:	eLife Vol. 10
Main Authors:	Munoz, Marcia A, Fletcher, Emma K, Skinner, Oliver P, Jurczyluk, Julie, Kristianto, Esther, Hodson, Mark P, Sun, Shuting, Ebetino, Frank H, Croucher, David R, Hansbro, Philip M, Center, Jacqueline R, Rogers, Michael J
Format:	Journal Article
Language:	English
Published:	England eLife Sciences Publications Ltd 30.12.2021 eLife Sciences Publications, Ltd
Subjects:	alveolar macrophage Animals Bacterial infections bisphosphonate Bisphosphonates Bone Density Conservation Agents - administration & dosage Bone Density Conservation Agents - pharmacology Bone diseases Bone loss Bone marrow Bronchus Chemokines Chemokines - metabolism Chromatography Cytokines Cytokines - metabolism Drug dosages Female Flow cytometry Fractures Immune response Immunosuppressive agents inflammasome Lavage Lipopolysaccharides - toxicity Lung - drug effects Lung - metabolism Macrophages Macrophages, Alveolar - drug effects Macrophages, Peritoneal - drug effects Mass spectrometry Medicine Mevalonate pathway Mevalonic acid Mevalonic Acid - metabolism Mice Mice, Inbred C57BL Mortality Osteoclasts Osteoporosis Pneumonia prenylation Protein Prenylation - drug effects Proteins Scientific imaging Short Report Skeleton Streptococcus infections Zoledronic acid Zoledronic Acid - administration & dosage Zoledronic Acid - pharmacology mouse alveolar macrophage pneumonia inflammasome bisphosphonate prenylation medicine osteoporosis
ISSN:	2050-084X, 2050-084X
Online Access:	Get full text
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