Magnetically-guided hydrogel capsule motors produced via ultrasound assisted hydrodynamic electrospray ionization jetting

[Display omitted] Hydrogel capsules are a potential candidate for drug delivery and an interesting alternative to polyelectrolyte multilayer capsules which are under investigation since 20 years. Recently introduced polyelectrolyte complex capsules produced by spraying are non-biodegradable and not...

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Bibliographic Details
Published in:Journal of colloid and interface science Vol. 541; pp. 407 - 417
Main Authors: Rutkowski, Sven, Si, Tieyan, Gai, Meiyu, Sun, Mengmeng, Frueh, Johannes, He, Qiang
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.04.2019
Subjects:
alginates
biodegradability
Biodegradable
calcium
crosslinking
drugs
electrodes
electrolytes
Electrospraying
encapsulation
hydrodynamics
Hydrogel capsules
hydrogels
ionization
magnetic fields
Magnetic guidance
Motors
mushrooms
spraying
Motors
Hydrogel capsules
Electrospraying
Biodegradable
Magnetic guidance
ISSN:0021-9797, 1095-7103, 1095-7103
Online Access:Get full text
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Summary:[Display omitted] Hydrogel capsules are a potential candidate for drug delivery and an interesting alternative to polyelectrolyte multilayer capsules which are under investigation since 20 years. Recently introduced polyelectrolyte complex capsules produced by spraying are non-biodegradable and not biocompatible, which limits their practical application, while biodegradable alginate capsules require complex coaxial electrospray ionization jetting. In this work, biodegradable alginate capsules cross-linked by calcium are successfully produced by hydrodynamic electrospray ionization jetting with the assistance of low frequency ultrasound. The size and shape of most capsules show significant differences with respect to different spraying distance, spraying mode, electrode shape and spraying concentration. Capsules in the shape of vase, mushrooms and spheres were successfully produced. Average capsule size can be adjusted from 10 μm to 2 mm. These capsules are used to encapsulate a model drug. Encapsulated paramagnetic particles enable defined directional motion under the propulsion of a rotating magnetic field, while model drugs can be released by ultrasound.
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ISSN:0021-9797
1095-7103
1095-7103
DOI:10.1016/j.jcis.2019.01.103