The Nucleotide-Free State of the Cannabinoid CB2/Gi Complex
In this issue of Cell, two papers report agonist-bound cryo-EM structures of the cannabinoid receptor, CB2, in complex with Gi. Importantly, beyond providing information that could help distinguish CB2 ligand binding from CB1, these structures support the existence of a nucleotide-free state during...
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| Veröffentlicht in: | Cell Jg. 180; H. 4; S. 603 |
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| Hauptverfasser: | , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
United States
20.02.2020
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| ISSN: | 1097-4172, 1097-4172 |
| Online-Zugang: | Weitere Angaben |
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| Zusammenfassung: | In this issue of Cell, two papers report agonist-bound cryo-EM structures of the cannabinoid receptor, CB2, in complex with Gi. Importantly, beyond providing information that could help distinguish CB2 ligand binding from CB1, these structures support the existence of a nucleotide-free state during G-protein signaling. |
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| Bibliographie: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Commentary-3 content type line 23 |
| ISSN: | 1097-4172 1097-4172 |
| DOI: | 10.1016/j.cell.2020.01.034 |