Diacerein attenuates vascular dysfunction by reducing inflammatory response and insulin resistance in type 2 diabetic rats

To examine the effect of diacerein on vascular dysfunction in type 2 diabetic rats and elucidate the mechanism of diacerein. In a rat model, type 2 diabetes was induced by high-fat diet and streptozotocin. Vascular function was assessed in vascular reactivity experiment. The effect of diacerein (10...

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Veröffentlicht in:Biochemical and biophysical research communications Jg. 585; S. 68 - 74
Hauptverfasser: He, An, Shen, Jian, Xue, Yuzhou, Xiang li, Li, Yuanjing, Huang, Longxiang, Lv, Dingyi, Luo, Minghao
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Elsevier Inc 31.12.2021
Schlagworte:
Animals
Anthraquinones - chemistry
Anthraquinones - pharmacology
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Aorta, Thoracic - drug effects
Aorta, Thoracic - metabolism
Aorta, Thoracic - physiopathology
blood glucose
Blood Glucose - metabolism
cytokines
Cytokines - metabolism
Diabetes
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Experimental - physiopathology
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - physiopathology
Diacerein
high fat diet
inflammation
Inflammation - metabolism
Inflammation - physiopathology
Inflammation - prevention & control
insulin
Insulin Resistance
insulin tolerance test
Male
Molecular Structure
NF-kappa B - metabolism
nitric oxide synthase
Nitric Oxide Synthase - metabolism
noninsulin-dependent diabetes mellitus
Rats
Rats, Sprague-Dawley
Signal Transduction - drug effects
streptozotocin
therapeutics
Vascular function
Vascular function
Diabetes
Diacerein
ISSN:0006-291X, 1090-2104, 1090-2104
Online-Zugang:Volltext
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Zusammenfassung:To examine the effect of diacerein on vascular dysfunction in type 2 diabetic rats and elucidate the mechanism of diacerein. In a rat model, type 2 diabetes was induced by high-fat diet and streptozotocin. Vascular function was assessed in vascular reactivity experiment. The effect of diacerein (10 or 20 mg/kg/day) on blood glucose, inflammation and insulin signaling, and modulators in vascular tissue in diabetic rats were investigated by molecular and biochemical approaches. In this study, diacerein inhibited diabetes-induced vascular dysfunction. Diacerein treatment normalized blood glucose, insulin tolerance test, inflammatory cytokine levels and nitric oxide synthases expression in diabetic rats. Moreover, diacerein inhibited NF-κB and NLRP3 pathways and activated insulin signaling pathway related proteins IRS-1 and AKT in diabetic rats. Diacerein improved vascular function effectively in diabetic rats by suppressing inflammation and reducing insulin resistance. These results suggest that diacerein may represent a novel therapy for patients with diabetes. •In our study, we found diacerein inhibited diabetes-induced vascular dysfunction for the first time.•Diacerein treatment normalized blood glucose, insulin resistance, inflammatory cytokine levels and endothelial nitric oxide synthase and inducible nitric oxide synthase expression in diabetic rats.•Diacerein inhibited NF-κB and NLRP3 pathways and activated insulin signaling pathway related proteins IRS-1 and AKT in diabetic rats.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-291X
1090-2104
1090-2104
DOI:10.1016/j.bbrc.2021.11.017