Seroprevalence of IgG specific for dengue virus among adults and children in Santo Domingo, Dominican Republic

The seroprevalence of dengue (DEN) virus-specific IgG was determined by enzyme-linked immunosorbent assay among 1,008 adults recruited at blood banks and among 201 children less than 10 years old visiting a hospital in Santo Domingo, Dominican Republic. Most (98%, 987 of 1,008) of the adults and 56%...

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Veröffentlicht in:The American journal of tropical medicine and hygiene Jg. 71; H. 2; S. 138
Hauptverfasser: Yamashiro, Tetsu, Disla, Mildre, Petit, Angela, Taveras, Delfis, Castro-Bello, Mercedez, Lora-Orste, Miguel, Vardez, Sonia, Cesin, Ana Julia, Garcia, Barbara, Nishizono, Akira
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.08.2004
Schlagworte:
Adolescent
Adult
Age Distribution
Aged
Antibodies, Viral - blood
Antibody Specificity
Child
Child, Preschool
Dengue - epidemiology
Dengue Virus - classification
Dengue Virus - immunology
Dominican Republic - epidemiology
Female
Humans
Immunoglobulin G - blood
Infant
Male
Middle Aged
Neutralization Tests
Seroepidemiologic Studies
Serotyping
Dominican Republic
ISSN:0002-9637
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Zusammenfassung:The seroprevalence of dengue (DEN) virus-specific IgG was determined by enzyme-linked immunosorbent assay among 1,008 adults recruited at blood banks and among 201 children less than 10 years old visiting a hospital in Santo Domingo, Dominican Republic. Most (98%, 987 of 1,008) of the adults and 56% (113 of 201) of the children were positive for DEN virus-specific IgG. Among adults, there were no significant differences in the prevalence by age, sex, and residential area of the participants. Among children, the prevalence of DEN virus-specific IgG increased with age (1-2 years old, 0-5%; 3-6 years old, 25-65%; and >/=7 years old, 76-92%). The prevalence in 50% of those less than one year of age was probably due to maternal antibody transfer. Neutralization tests of adult samples indicate that DEN virus infections with different serotypes have occurred sequentially or simultaneously among the inhabitants of Santo Domingo.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0002-9637
DOI:10.4269/ajtmh.2004.71.138