Line‐field confocal optical coherence tomography—Practical applications in dermatology and comparison with established imaging methods

Background Non‐invasive diagnostic techniques in dermatology gained increasing popularity in the last decade. Reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) are meanwhile established in research and clinical routine. While OCT is mainly indicated for detecting non‐melan...

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Published in:Skin research and technology Vol. 27; no. 3; pp. 340 - 352
Main Authors: Ruini, Cristel, Schuh, Sandra, Sattler, Elke, Welzel, Julia
Format: Journal Article
Language:English
Published: England John Wiley & Sons, Inc 01.05.2021
Subjects:
Basal cell carcinoma
Cancer
Confocal microscopy
Dermatology
Histology
Keratosis
Lesions
line‐field confocal OCT
Melanoma
Optical Coherence Tomography
Penetration depth
reflectance confocal microscopy
Skin
Skin cancer
Skin diseases
skin imaging
Skin lesions
Tomography
reflectance confocal microscopy
skin cancer
line-field confocal OCT
dermatology
skin imaging
optical coherence tomography
ISSN:0909-752X, 1600-0846, 1600-0846
Online Access:Get full text
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Summary:Background Non‐invasive diagnostic techniques in dermatology gained increasing popularity in the last decade. Reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) are meanwhile established in research and clinical routine. While OCT is mainly indicated for detecting non‐melanoma skin cancer, RCM has proven its usefulness additionally in distinguishing melanocytic lesions. Line‐field confocal optical coherence tomography (LC‐OCT) is an emerging tool combining the principles of both above‐mentioned methods. Methods Healthy skin at different body sites and exemplary skin lesions (basal cell carcinoma, malignant melanoma, actinic keratosis) were examined using dermoscopy, RCM, OCT and LC‐OCT. Standard features for RCM and OCT and comparable features for LC‐OCT were analysed. Results LC‐OCT has a lower penetration depth but superior resolution compared to OCT. In comparison with RCM, which provides only horizontal sections, LC‐OCT creates both vertical and horizontal images in real time and has nearly the same cellular resolution. Discussion Our preliminary experiences suggest that LC‐OCT combines the advantages of RCM and OCT, with optimal resolution and penetration depth to diagnose all types of skin cancer. Larger systematic studies are needed to further characterize the field of use of this device and its sensitivity and specificity compared to histology.
Bibliography:Funding information
FöFoLe (Förderprogramm für Forschung und Lehre) Grant of the Ludwig Maximilian University of Munich 1022‐2018.
Cristel Ruini, Sandra Schuh, Elke Sattler and Julia Welzel contributed equally.
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ISSN:0909-752X
1600-0846
1600-0846
DOI:10.1111/srt.12949