BMP6 and VDR gene polymorphisms are associated with osteonecrosis in a sickle cell anaemia cohort

Summary The occurrence and severity of osteonecrosis in sickle cell anaemia (SCA) vary due to risk factors, including genetic modifiers. Bone morphogenetic proteins (BMPs), particularly BMP6, and the vitamin D receptor (VDR) play key roles in cartilage and bone metabolism, making them potential cont...

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Vydané v:	British journal of haematology Ročník 204; číslo 4; s. 1507 - 1514
Hlavní autori:	Arcanjo, Gabriela S., Souza, Mariana B., Domingos, Igor F., Pereira‐Martins, Diego A., Falcão, Diego A., Batista, Jessica V., Hatzlhofer, Betania L., Diniz, Madi V., Silva, Alexsandro P., Guaraná, Werbson L., Hazin, Manuela F., Araujo, Aderson S., Cunha, Anderson F., Saad, Sara O., Costa, Fernando F., Lucena‐Araujo, Antonio R., Bezerra, Marcos André C.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Blackwell Publishing Ltd 01.04.2024
Predmet:	Anemia avascular necrosis Bone morphogenetic protein 6 Bone morphogenetic proteins bone morphogenic proteins Bone turnover CDX2 protein Gene polymorphism Necrosis Osteonecrosis Risk factors rs3812163 Sickle cell anemia Sickle cell disease vitamin D receptor Vitamin D receptors rs3812163 vitamin D receptor avascular necrosis bone morphogenic proteins sickle cell disease
ISSN:	0007-1048, 1365-2141, 1365-2141
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