Tuberculosis impacts multiple aspects in quality of life in a Romanian cohort of drug‐susceptible and drug resistant patients: A patient‐reported outcome measures study

Background Tuberculosis (TB), and especially its drug resistant forms, is responsible for not only significant mortality, but also considerable morbidity, still under‐quantified. This study used four Patient‐Reported Outcome Measures (PROMS) to assess the status of persons affected by drug‐susceptib...

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Vydáno v:Tropical medicine & international health Ročník 29; číslo 7; s. 584 - 593
Hlavní autoři: Margineanu, Ioana, Butnaru, Teodora, Lam, Marjolein, Baiceanu, Dragos, Dragomir, Raluca, Arbore, Adriana Sorete, Mahler, Beatrice, Munteanu, Ioana, Mihaltan, Florin, Akkerman, Onno, Alffenaar, Jan‐Willem, Stienstra, Ymkje
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Blackwell Publishing Ltd 01.07.2024
Témata:
clinical management
Clinical outcomes
Cross-sectional studies
Drug development
Drug resistance
Epidemiology
Hearing loss
Morbidity
Patients
public health
Quality of life
Rehabilitation
Statistical analysis
Statistical tests
Tuberculosis
Romania
clinical management
quality of life
public health
tuberculosis
ISSN:1360-2276, 1365-3156, 1365-3156
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Shrnutí:Background Tuberculosis (TB), and especially its drug resistant forms, is responsible for not only significant mortality, but also considerable morbidity, still under‐quantified. This study used four Patient‐Reported Outcome Measures (PROMS) to assess the status of persons affected by drug‐susceptible and drug‐resistant TB during their TB treatment or after treatment completion, in Romania, the highest TB burden country in the EU. Methods People affected by TB in two different regions in Romania were included during and after treatment, following a cross‐sectional design. PROMs used were SF‐36, EQ‐5D‐5L, WPAI and the app‐based audiometry screening tool ‘uHear.’ Descriptive statistics and relevant statistical tests were used to compare groups between themselves and with the general Romanian population. Results Both patients with drug‐susceptible and drug‐resistant TB experience, with drug‐resistant patients experiencing statistically significantly more pain and hearing loss. PROMs show some improvement in the after‐treatment group; however, compared with the general Romanian population for which data were available, all groups scored lower on all outcome measures. Conclusion PROMs offer the possibility of obtaining a more comprehensive view of patients' status, by involving them directly in the medical process and could guide a rehabilitation strategy.
Bibliografie:Ioana Margineanu and Teodora Butnaru are joint first authors.
Good Health and Well‐being; Decent Work and Economic Growth
Sustainable Development Goal
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ISSN:1360-2276
1365-3156
1365-3156
DOI:10.1111/tmi.13996