The structural, functional, and dynamic effect of Tau tubulin kinase1 upon a mutation: A neuro‐degenerative hotspot

Alzheimer's disease (AD) is a progressive disorder that causes brain cells to degenerate and die. AD is one of the common causes of dementia that leads to a decline in thinking, behavioral and social skills that disrupts a person's ability to function independently. Tau‐tubulin kinase1 (TT...

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Bibliographic Details
Published in:	Journal of cellular biochemistry Vol. 122; no. 11; pp. 1653 - 1664
Main Authors:	Ahamad, Shahzaib, Hema, Kanipakam, Kumar, Vijay, Gupta, Dinesh
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01.11.2021
Subjects:	Alzheimer Disease - genetics Alzheimer's disease Central nervous system computational algorithms Computational neuroscience Dementia disorders Destabilization FEL analysis Filaments Free energy Gene mapping Genetic diversity Humans Hydrogen bonding Models, Molecular Molecular dynamics Molecular Dynamics Simulation Molecular structure Mutants Mutation Neurodegenerative diseases Pathogenesis Phosphorylation Principal Component Analysis Protein Serine-Threonine Kinases - chemistry Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Protein Stability Protein Structure, Secondary Proteins R142Q Residues Structural stability Structure-function relationships Tau protein Therapeutic targets Threonine TTBK1 Tubulin computational algorithms FEL analysis Alzheimer's disease R142Q TTBK1 molecular dynamics simulation
ISSN:	0730-2312, 1097-4644, 1097-4644
Online Access:	Get full text
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