Voltage‐dependent conformational changes of Kv1.3 channels activate cell proliferation

The voltage‐dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, nonc...

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Bibliographic Details
Published in:	Journal of cellular physiology Vol. 236; no. 6; pp. 4330 - 4347
Main Authors:	Cidad, Pilar, Alonso, Esperanza, Arévalo‐Martínez, Marycarmen, Calvo, Enrique, Fuente, Miguel A., Pérez‐García, M. Teresa, López‐López, José R.
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01.06.2021
Subjects:	Calcium channels Calcium influx Calcium ions Cell cycle Cell growth Cell proliferation Cell size Channel gating Channels Depolarization Efflux Electric potential Fluxes IQGAP3 Kv1.3 channels Membrane potential Membranes Molecular dynamics Muscles Mutation Phosphorylation Potassium Potassium channels (voltage-gated) Smooth muscle Vascular smooth muscle cells Voltage cell proliferation cell cycle IQGAP3 Kv1.3 channels Vascular smooth muscle cells membrane potential
ISSN:	0021-9541, 1097-4652, 1097-4652
Online Access:	Get full text
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