GPA-Tree: statistical approach for functional-annotation-tree-guided prioritization of GWAS results

Abstract Motivation In spite of great success of genome-wide association studies (GWAS), multiple challenges still remain. First, complex traits are often associated with many single nucleotide polymorphisms (SNPs), each with small or moderate effect sizes. Second, our understanding of the functiona...

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Veröffentlicht in:	Bioinformatics Jg. 38; H. 4; S. 1067 - 1074
Hauptverfasser:	Khatiwada, Aastha, Wolf, Bethany J, Yilmaz, Ayse Selen, Ramos, Paula S, Pietrzak, Maciej, Lawson, Andrew, Hunt, Kelly J, Kim, Hang J, Chung, Dongjun
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Oxford University Press 27.01.2022
Schlagworte:	Algorithms Computer Simulation Genome-Wide Association Study - methods Original Papers Polymorphism, Single Nucleotide Software
ISSN:	1367-4803, 1367-4811, 1460-2059, 1367-4811
Online-Zugang:	Volltext
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