Downregulation of fascin in the first trimester placental villi is associated with early recurrent miscarriage

Inadequate trophoblast proliferation, shallow invasion and exaggerated rate of trophoblast apoptosis are implicated in early recurrent miscarriage (ERM). However, the mechanistic bases of this association have not been fully established. We aimed at investigating the involvement of fascin, an actin-...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Experimental cell research Ročník 403; číslo 1; s. 112597
Hlavní autori:	Lamptey, Jones, Li, Fangfang, Adu-Gyamfi, Enoch Appiah, Chen, Xue-Mei, Czika, Armin, Otoo, Antonia, Liu, Tai-Hang, Wang, Ying-Xiong, Ding, Yu-Bin
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Elsevier Inc 01.06.2021
Predmet:	60 APPLIED LIFE SCIENCES ACTIN ANOXIA APOPTOSIS CELL PROLIFERATION Fascin Hypoxia reoxygenation MOLECULES MORPHOLOGY PATHOGENESIS PHOSPHOTRANSFERASES PREGNANCY Recurrent miscarriage TRANSCRIPTION FACTORS Trophoblast Recurrent miscarriage Trophoblast Hypoxia reoxygenation Fascin
ISSN:	0014-4827, 1090-2422, 1090-2422
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	Inadequate trophoblast proliferation, shallow invasion and exaggerated rate of trophoblast apoptosis are implicated in early recurrent miscarriage (ERM). However, the mechanistic bases of this association have not been fully established. We aimed at investigating the involvement of fascin, an actin-bundling protein, in trophoblast activities and ERM. We found that fascin was downregulated in the cytotrophoblasts (CTBs) and distal cytotrophoblasts (DCTs) of ERM placentae. Knockdown of fascin altered cellular and nucleolar morphology, and inhibited the proliferation but increased apoptosis of trophoblastic HTR8/SVneo cells. Furthermore, fascin knockdown decreased the expression of transcription factors such as Snail1/2, Twist and Zeb1/2, mesenchymal molecules such as Vimentin and N-cadherin, and the protein expression of phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2) and phosphorylates signal transducer and activator of transcript 3 (STAT3). Exposure of HTR-8/SVneo cells to hypoxia reoxygenation (H/R) decreased fascin expression to affect the cells’ invasion. Our results indicate for the first time that the downregulation of fascin is involved in the pathogenesis of early recurrent miscarriage; and hence a potential therapeutic target against the disease. •Fascin is downregulated in the placentae of pregnancies complicated by early recurrent miscarriage.•Knockdown of fascin decreased HTR-8/SVneo cells' proliferation, migration and invasion.•Fascin knockdown decreased phosphorylated ERK1/2 and phosphorylated STAT3 protein level in HTR-8/SVneo cells.•Hypoxia reoxygenation decreased fascin, N-Cadherin and Vimentin protein levels to affect HTR-8/SVneo cells' invasion.
AbstractList	Inadequate trophoblast proliferation, shallow invasion and exaggerated rate of trophoblast apoptosis are implicated in early recurrent miscarriage (ERM). However, the mechanistic bases of this association have not been fully established. We aimed at investigating the involvement of fascin, an actin-bundling protein, in trophoblast activities and ERM. We found that fascin was downregulated in the cytotrophoblasts (CTBs) and distal cytotrophoblasts (DCTs) of ERM placentae. Knockdown of fascin altered cellular and nucleolar morphology, and inhibited the proliferation but increased apoptosis of trophoblastic HTR8/SVneo cells. Furthermore, fascin knockdown decreased the expression of transcription factors such as Snail1/2, Twist and Zeb1/2, mesenchymal molecules such as Vimentin and N-cadherin, and the protein expression of phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2) and phosphorylates signal transducer and activator of transcript 3 (STAT3). Exposure of HTR-8/SVneo cells to hypoxia reoxygenation (H/R) decreased fascin expression to affect the cells' invasion. Our results indicate for the first time that the downregulation of fascin is involved in the pathogenesis of early recurrent miscarriage; and hence a potential therapeutic target against the disease. Inadequate trophoblast proliferation, shallow invasion and exaggerated rate of trophoblast apoptosis are implicated in early recurrent miscarriage (ERM). However, the mechanistic bases of this association have not been fully established. We aimed at investigating the involvement of fascin, an actin-bundling protein, in trophoblast activities and ERM. We found that fascin was downregulated in the cytotrophoblasts (CTBs) and distal cytotrophoblasts (DCTs) of ERM placentae. Knockdown of fascin altered cellular and nucleolar morphology, and inhibited the proliferation but increased apoptosis of trophoblastic HTR8/SVneo cells. Furthermore, fascin knockdown decreased the expression of transcription factors such as Snail1/2, Twist and Zeb1/2, mesenchymal molecules such as Vimentin and N-cadherin, and the protein expression of phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2) and phosphorylates signal transducer and activator of transcript 3 (STAT3). Exposure of HTR-8/SVneo cells to hypoxia reoxygenation (H/R) decreased fascin expression to affect the cells' invasion. Our results indicate for the first time that the downregulation of fascin is involved in the pathogenesis of early recurrent miscarriage; and hence a potential therapeutic target against the disease.Inadequate trophoblast proliferation, shallow invasion and exaggerated rate of trophoblast apoptosis are implicated in early recurrent miscarriage (ERM). However, the mechanistic bases of this association have not been fully established. We aimed at investigating the involvement of fascin, an actin-bundling protein, in trophoblast activities and ERM. We found that fascin was downregulated in the cytotrophoblasts (CTBs) and distal cytotrophoblasts (DCTs) of ERM placentae. Knockdown of fascin altered cellular and nucleolar morphology, and inhibited the proliferation but increased apoptosis of trophoblastic HTR8/SVneo cells. Furthermore, fascin knockdown decreased the expression of transcription factors such as Snail1/2, Twist and Zeb1/2, mesenchymal molecules such as Vimentin and N-cadherin, and the protein expression of phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2) and phosphorylates signal transducer and activator of transcript 3 (STAT3). Exposure of HTR-8/SVneo cells to hypoxia reoxygenation (H/R) decreased fascin expression to affect the cells' invasion. Our results indicate for the first time that the downregulation of fascin is involved in the pathogenesis of early recurrent miscarriage; and hence a potential therapeutic target against the disease. Highlights: • Fascin is downregulated in the placentae of pregnancies complicated by early recurrent miscarriage. • Knockdown of fascin decreased HTR-8/SVneo cells' proliferation, migration and invasion. • Fascin knockdown decreased phosphorylated ERK1/2 and phosphorylated STAT3 protein level in HTR-8/SVneo cells. • Hypoxia reoxygenation decreased fascin, N-Cadherin and Vimentin protein levels to affect HTR-8/SVneo cells' invasion. Inadequate trophoblast proliferation, shallow invasion and exaggerated rate of trophoblast apoptosis are implicated in early recurrent miscarriage (ERM). However, the mechanistic bases of this association have not been fully established. We aimed at investigating the involvement of fascin, an actin-bundling protein, in trophoblast activities and ERM. We found that fascin was downregulated in the cytotrophoblasts (CTBs) and distal cytotrophoblasts (DCTs) of ERM placentae. Knockdown of fascin altered cellular and nucleolar morphology, and inhibited the proliferation but increased apoptosis of trophoblastic HTR8/SVneo cells. Furthermore, fascin knockdown decreased the expression of transcription factors such as Snail1/2, Twist and Zeb1/2, mesenchymal molecules such as Vimentin and N-cadherin, and the protein expression of phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2) and phosphorylates signal transducer and activator of transcript 3 (STAT3). Exposure of HTR-8/SVneo cells to hypoxia reoxygenation (H/R) decreased fascin expression to affect the cells’ invasion. Our results indicate for the first time that the downregulation of fascin is involved in the pathogenesis of early recurrent miscarriage; and hence a potential therapeutic target against the disease. Inadequate trophoblast proliferation, shallow invasion and exaggerated rate of trophoblast apoptosis are implicated in early recurrent miscarriage (ERM). However, the mechanistic bases of this association have not been fully established. We aimed at investigating the involvement of fascin, an actin-bundling protein, in trophoblast activities and ERM. We found that fascin was downregulated in the cytotrophoblasts (CTBs) and distal cytotrophoblasts (DCTs) of ERM placentae. Knockdown of fascin altered cellular and nucleolar morphology, and inhibited the proliferation but increased apoptosis of trophoblastic HTR8/SVneo cells. Furthermore, fascin knockdown decreased the expression of transcription factors such as Snail1/2, Twist and Zeb1/2, mesenchymal molecules such as Vimentin and N-cadherin, and the protein expression of phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2) and phosphorylates signal transducer and activator of transcript 3 (STAT3). Exposure of HTR-8/SVneo cells to hypoxia reoxygenation (H/R) decreased fascin expression to affect the cells’ invasion. Our results indicate for the first time that the downregulation of fascin is involved in the pathogenesis of early recurrent miscarriage; and hence a potential therapeutic target against the disease. •Fascin is downregulated in the placentae of pregnancies complicated by early recurrent miscarriage.•Knockdown of fascin decreased HTR-8/SVneo cells' proliferation, migration and invasion.•Fascin knockdown decreased phosphorylated ERK1/2 and phosphorylated STAT3 protein level in HTR-8/SVneo cells.•Hypoxia reoxygenation decreased fascin, N-Cadherin and Vimentin protein levels to affect HTR-8/SVneo cells' invasion.
ArticleNumber	112597
Author	Liu, Tai-Hang Wang, Ying-Xiong Czika, Armin Lamptey, Jones Adu-Gyamfi, Enoch Appiah Otoo, Antonia Chen, Xue-Mei Ding, Yu-Bin Li, Fangfang
Author_xml	– sequence: 1 givenname: Jones orcidid: 0000-0002-7050-1674 surname: Lamptey fullname: Lamptey, Jones organization: Department of Genetics, School of Basic Medicine, Chongqing Medical University, Chongqing, 400016, PR China – sequence: 2 givenname: Fangfang surname: Li fullname: Li, Fangfang organization: The Joint International Research Laboratory of Reproduction and Development, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, PR China – sequence: 3 givenname: Enoch Appiah surname: Adu-Gyamfi fullname: Adu-Gyamfi, Enoch Appiah organization: Department of Genetics, School of Basic Medicine, Chongqing Medical University, Chongqing, 400016, PR China – sequence: 4 givenname: Xue-Mei surname: Chen fullname: Chen, Xue-Mei organization: The Joint International Research Laboratory of Reproduction and Development, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, PR China – sequence: 5 givenname: Armin orcidid: 0000-0002-0801-770X surname: Czika fullname: Czika, Armin organization: Department of Genetics, School of Basic Medicine, Chongqing Medical University, Chongqing, 400016, PR China – sequence: 6 givenname: Antonia surname: Otoo fullname: Otoo, Antonia organization: Department of Genetics, School of Basic Medicine, Chongqing Medical University, Chongqing, 400016, PR China – sequence: 7 givenname: Tai-Hang surname: Liu fullname: Liu, Tai-Hang organization: The Joint International Research Laboratory of Reproduction and Development, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, PR China – sequence: 8 givenname: Ying-Xiong surname: Wang fullname: Wang, Ying-Xiong email: 1600347366@qq.com organization: Department of Genetics, School of Basic Medicine, Chongqing Medical University, Chongqing, 400016, PR China – sequence: 9 givenname: Yu-Bin surname: Ding fullname: Ding, Yu-Bin email: dingyb@cqmu.edu.cn organization: The Joint International Research Laboratory of Reproduction and Development, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, PR China
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/33862100$$D View this record in MEDLINE/PubMed https://www.osti.gov/biblio/23195287$$D View this record in Osti.gov
BookMark	eNp9kUtrHDEQhEVwiNdOfkEgCHLJZTZ6zOxIhxyC8wRDLslZ9Eo9Xi1aaSNpbO-_z4zHvuRgEPTlq25V1QU5iykiIW85W3PGNx_36xPe27wWTPA156LT_Quy4kyzRrRCnJEVY7xtWiX6c3JRyp4xphTfvCLnUqqN4IytSPyS7mLGmzFA9SnSNNABivWRTq_ukA4-l0pr9gcsFTM9BrAYKwR660Pw1BcKpSTroaKjd77uKEIOJ5rRjjlPKD34YiFnDzf4mrwcIBR88zgvyZ9vX39f_Wiuf33_efX5urFS9bVB5xCVtHqrlOVats71zAEbpB0EKBCtVd3gQGuHTnMG3VYq6J3uWbdVrpeX5P2yN5XqzeSnot3ZFCPaaoTkuhNqpj4s1DGnv-Pkz8xfxRAgYhqLER1vO6005xP67hEdtwd05jgFAvlknpKcAL0ANqdSMg5mOvqQac3gg-HMzK2ZvXlozcytmaW1SSv_0z6tf171aVHhFOStxzz7xGjR-TzbdMk_q_8HSC-0Hw
CitedBy_id	crossref_primary_10_3389_fimmu_2023_1331964 crossref_primary_10_1007_s43032_024_01555_2 crossref_primary_10_1016_j_tice_2021_101662 crossref_primary_10_26508_lsa_202302247 crossref_primary_10_1016_j_yexcr_2022_113428 crossref_primary_10_1007_s11033_024_09220_2 crossref_primary_10_1016_j_yexcr_2021_112885 crossref_primary_10_1016_j_theriogenology_2025_117499 crossref_primary_10_4014_jmb_2112_12056 crossref_primary_10_1016_j_placenta_2021_06_004 crossref_primary_10_1016_j_jri_2022_103666 crossref_primary_10_1177_09603271231163476
Cites_doi	10.4331/wjbc.v6.i4.346 10.1016/j.placenta.2015.04.001 10.3389/fimmu.2018.02597 10.1210/jc.2015-2134 10.1080/19336918.2016.1170258 10.1210/jc.2014-1897 10.1111/aji.12436 10.1128/MCB.17.11.6508 10.1177/1933719113488448 10.1186/1477-7827-2-15 10.1152/ajpcell.00154.2010 10.3390/ijms20133263 10.1002/cbin.10786 10.1016/j.ymthe.2018.09.018 10.3892/ijo.2013.2232 10.1159/000493622 10.1096/fj.202000716RR 10.1158/0008-5472.CAN-13-3009 10.1074/jbc.M113.488866 10.3892/ol.2014.2451 10.1007/s00418-016-1509-5 10.1159/000147847 10.1038/s41598-018-38374-w 10.1016/j.ymthe.2018.07.009 10.3390/biology9110403 10.1016/j.placenta.2020.07.008 10.1159/000262608 10.1016/j.omtn.2018.12.011 10.1371/journal.pcbi.1007156 10.4161/jkst.25155 10.1002/1099-0844(200009)18:3<169::AID-CBF870>3.0.CO;2-T 10.3349/ymj.2016.57.3.761 10.1016/S0002-9440(10)64849-3 10.1038/s41598-017-16196-6 10.1091/mbc.E15-09-0634 10.1096/fj.201801898RR 10.1038/ncomms12603 10.1038/srep36699 10.1210/jc.2018-01717 10.1016/j.redox.2017.03.014 10.1016/S0009-8981(99)00255-7 10.1091/mbc.E14-09-1384 10.1371/journal.pone.0028514 10.1093/humupd/dmn010 10.1016/j.biopha.2017.09.019 10.1053/plac.2000.0543 10.1186/1476-4598-6-24 10.1111/aji.13144 10.1210/en.2017-00536 10.1371/journal.pone.0076605 10.1210/jc.2014-2118 10.1126/science.277.5332.1669 10.1016/j.biopha.2015.05.014 10.1093/biolre/ioz186 10.1186/1471-2407-12-32 10.1007/s43032-020-00364-7 10.3892/etm.2015.2266
ContentType	Journal Article
Copyright	2021 Elsevier Inc. Copyright © 2021 Elsevier Inc. All rights reserved.
Copyright_xml	– notice: 2021 Elsevier Inc. – notice: Copyright © 2021 Elsevier Inc. All rights reserved.
DBID	AAYXX CITATION NPM 7X8 OTOTI
DOI	10.1016/j.yexcr.2021.112597
DatabaseName	CrossRef PubMed MEDLINE - Academic OSTI.GOV
DatabaseTitle	CrossRef PubMed MEDLINE - Academic
DatabaseTitleList	PubMed MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
EISSN	1090-2422
ExternalDocumentID	23195287 33862100 10_1016_j_yexcr_2021_112597 S0014482721001294
Genre	Journal Article
GroupedDBID	--- --K --M -DZ -~X .~1 0R~ 1B1 1RT 1~. 1~5 4.4 457 4G. 5GY 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAXUO ABFNM ABFRF ABGSF ABJNI ABMAC ABOCM ABPPZ ABUDA ABYKQ ACDAQ ACGFO ACGFS ACNCT ACPRK ACRLP ADBBV ADEZE ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC C45 CS3 DM4 DOVZS DU5 EBS EFBJH EFLBG EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA IHE J1W K-O KOM L7B LG5 LX2 M41 MO0 N9A O-L O9- OAUVE OVD OZT P-8 P-9 P2P PC. PQQKQ Q38 RNS ROL RPZ SCC SDF SDG SDP SES SPCBC SSU SSZ T5K TEORI TWZ VQA WH7 Y6R YZZ ZA5 ZCA ZMT ZU3 ~G- ~KM .55 .GJ 29G 3O- 53G 9DU 9M8 AAQXK AATTM AAXKI AAYWO AAYXX ABDPE ABEFU ABUFD ABWVN ABXDB ACKIV ACLOT ACRPL ACVFH ADCNI ADFGL ADMUD ADNMO ADVLN ADXHL AEIPS AETEA AEUPX AFJKZ AFPUW AGHFR AGQPQ AGRDE AI. AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP ASPBG AVWKF AZFZN CAG CITATION COF EFKBS EJD FA8 FEDTE FGOYB G-2 HLW HVGLF HZ~ LPU MVM NEJ OHT R2- SBG SEW VH1 WUQ X7L X7M XOL XPP YYP ZGI ZKB ~HD BNPGV NPM SSH 7X8 AALMO AAPBV ABPIF ABPTK ABQIS EFJIC OTOTI PQEST
ID	FETCH-LOGICAL-c387t-eddee83c9b88c1934dd70da0f3cf2a8a24c85fda99ded910a5b38a7d9705b8d73
ISICitedReferencesCount	11
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000645097800012&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0014-4827 1090-2422
IngestDate	Mon Jun 19 03:48:57 EDT 2023 Sun Sep 28 02:31:58 EDT 2025 Thu Apr 03 07:08:09 EDT 2025 Sat Nov 29 07:30:24 EST 2025 Tue Nov 18 21:21:10 EST 2025 Fri Feb 23 02:45:05 EST 2024
IsPeerReviewed	true
IsScholarly	true
Issue	1
Keywords	Recurrent miscarriage Trophoblast Hypoxia reoxygenation Fascin
Language	English
License	Copyright © 2021 Elsevier Inc. All rights reserved.
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c387t-eddee83c9b88c1934dd70da0f3cf2a8a24c85fda99ded910a5b38a7d9705b8d73
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ORCID	0000-0002-0801-770X 0000-0002-7050-1674
PMID	33862100
PQID	2514598911
PQPubID	23479
ParticipantIDs	osti_scitechconnect_23195287 proquest_miscellaneous_2514598911 pubmed_primary_33862100 crossref_citationtrail_10_1016_j_yexcr_2021_112597 crossref_primary_10_1016_j_yexcr_2021_112597 elsevier_sciencedirect_doi_10_1016_j_yexcr_2021_112597
PublicationCentury	2000
PublicationDate	2021-06-01
PublicationDateYYYYMMDD	2021-06-01
PublicationDate_xml	– month: 06 year: 2021 text: 2021-06-01 day: 01
PublicationDecade	2020
PublicationPlace	United States
PublicationPlace_xml	– name: United States
PublicationTitle	Experimental cell research
PublicationTitleAlternate	Exp Cell Res
PublicationYear	2021
Publisher	Elsevier Inc
Publisher_xml	– name: Elsevier Inc
References	Alves, Rapp (bib3) 2020 Poli, Ruggiero, Cantini, Canu, Baroni, Armignacco (bib11) 2018 Nov 23; 104 Hou, Guo, Xie, Li, Xu (bib12) 2009 Jul 22; 2 Zhao, Gao, Sun, Zhang, Sun, Yang (bib62) 2014 Jan 5; 74 Li, Klausen, Zhu, Leung (bib52) 2015 Nov 1; 100 Li, Ma, Tian, Wu, Zhang, Zeng (bib25) 2019 Jul 1; 82 Gao, Zhang, Li, Li, Sang, Zhao (bib40) 2019 Feb 6; 27 Loukil (bib23) 2015; 6 Chen, Longtine, Sadovsky, Nelson (bib55) 2010 Nov; 299 Lia, Lid, Lud (bib20) 2018; 710061 Ma, Li, Tian, Zeng, Zhang, Mo (bib2) 2020 Mar 13 Soundararajan, Rao (bib33) 2004 Mar 25; 2 Lamb, Tootle (bib15) 2020 Nov 17; 9 Alam, Bhate, Gangadaran, Sawant, Salot, Sehgal (bib41) 2012 Jan 20; 12 Zhang, Li, Fu, Adu-Gyamfi, Xu, Liu (bib16) 2020 Oct 1; 100 Moser, Weiss, Sundl, Gauster, Siwetz, Lang-Olip (bib46) 2017 Mar 1; 147 Brki, Dunk, O’brien, Fu, Nadeem, Wang (bib8) 2018 Sep 5; 26 Peng, Zhu, Leung (bib39) 2015 Jan 1; 100 Thompson, Crimmins, Telugu, Turan (bib56) 2015 Sep 15; 5 Peng, Du, Zhang, Du, Jin, Gong (bib60) 2015; 9 Cheng, Chang, Leung (bib50) 2013 Nov 15; 288 Wang, Jia, Jiang, Gao, Wang (bib18) 2017 Aug; 41 Cheng, Chang, Leung (bib48) 2017 Oct 1; 158 Liu, Ning, Xu, Cao, Meng, Wang (bib19) 2016 Dec 22; 7 Gao, Zhang, Li, Li, Sang, Zhao (bib21) 2019; 27 Adu-Gyamfi, Wang, Ding (bib9) 2020 Feb 12; 102 Yang, Bai, Luo, Xiao, Liu, Ding (bib54) 2014 Jan 30; 21 Li, Klausen, Cheng, Zhu, Leung, Activin (bib51) 2014 Nov 1; 99 Zhang, Lu, Zhang, Huang, Wu, Zhang (bib61) 2018 Mar 20; 52 Xu, Chang, Du, Hou (bib29) 2017 Nov; 95 Kelpsch, Groen, Fagan, Sudhir, Tootle (bib26) 2016 Oct 1; 27 Marinello, Mohseni, Cunningham, Crute, Huang, Zhang (bib24) 2020 Nov 9; 34 Fitzgerald, Poehlmann, Schleussner, Markert (bib43) 2008 Jul; 14 Vural, Akgül, Yildirim, Canbaz (bib66) 2000 May 1; 295 Groen, Jayo, Parsons, Tootle (bib27) 2015 May 15; 26 Ko, Park, Choi, Kang, Kim, Kim (bib42) 2016 May 1; 57 Duzyj, Buhimschi, Motawea, Laky, Cozzini, Zhao (bib38) 2015 Jun 1; 36 Lv, Wang, Lv, Yang, Liu, Li (bib1) 2019 Mar 1; 14 Bojić-Trbojević, Jovanović Krivokuća, Vilotić, Kolundžić, Stefanoska, Zetterberg (bib5) 2019 Dec 1; 9 Zuo, Fu, Hu, Li, Xu, Sun (bib49) 2014 Nov 1; 8 Yamanaka-Tatematsu, Nakashima, Fujita, Shima, Yoshimori, Saito (bib59) 2013 Oct 3; 8 Kolundžić, Kovačević, Stefanoska, Kadoya, Vićovac (bib4) 2011 Dec 8; 6 Liu, Jiang, Huang, Yu (bib34) 2020 Oct 19; 2020 Davies J, Pollheimer, Yong, Kokkinos, Kalionis, Knöfler (bib37) 2016 May 3; 10 Toy, Camuzcuoglu, Camuzcuoglu, Celik, Aksoy (bib64) 2010 Mar; 69 Genbacev, Zhou, Ludlow, Fisher (bib57) 1997 Sep 12; 277 Jauniaux, Watson, Hempstock, Bao, Skepper, Burton (bib63) 2000; 157 Pollheimer, Vondra, Baltayeva, Beristain, Knöfler (bib7) 2018 Nov 13; 9 Chung, Uchida, Grammer, Blenis (bib44) 1997 Nov; 17 Alao (bib22) 2007 Apr 2; 6 Adu-Gyamfi, Czika, Gorleku, Ullah, Panhwar, Ruan (bib6) 2020; 28 Saad, Bijian, Qiu, Da Silva, Marques, Chang (bib14) 2016 Dec 7; 6 Naziroglu, Kokcam (bib65) 2000 Sep; 18 Chandrasekaran, Upadhyaya, Papoian (bib10) 2019 Jul 1; 15 Park, Song, Kim, Heo, Kang, Kim (bib13) 2014 Mar; 44 Gupta, Malhotra, Malik, Verma, Chaudhary (bib35) 2016 Mar 1; 75 Suman, Malhotra, Gupta (bib45) 2013 Oct 16; 2 Hanker, Karn, Holtrich, Graeser, Becker, Reinhard (bib30) 2013 Feb; 33 Vićovac, Aplin (bib36) 1996 Jan 1; 156 Adu-Gyamfi, Ding, Wang (bib47) 2020 Feb 12; 102 Shih, Lin, Hsiao, Su, Tsai, Chien (bib53) 2019 May 1; 33 Wang, Tang, Wang, Jin, Wang, Li (bib17) 2017 Nov 21; 7 Lewinska, Bednarz, Adamczyk-Grochala, Wnuk (bib28) 2017 Aug 1; 12 Graham, Postovit, Park, Canning, Fitzpatrick (bib58) 2000 Jul 1; 21 Luo, Yin, Li, Xu, Mei, Feng (bib31) 2015 Jul; 73 Ridder, Giorgione, Khalil, Thilaganathan (bib32) 2019 Jul 1; 20 Zhang (10.1016/j.yexcr.2021.112597_bib16) 2020; 100 Adu-Gyamfi (10.1016/j.yexcr.2021.112597_bib47) 2020; 102 Gupta (10.1016/j.yexcr.2021.112597_bib35) 2016; 75 Vural (10.1016/j.yexcr.2021.112597_bib66) 2000; 295 Graham (10.1016/j.yexcr.2021.112597_bib58) 2000; 21 Lv (10.1016/j.yexcr.2021.112597_bib1) 2019; 14 Kelpsch (10.1016/j.yexcr.2021.112597_bib26) 2016; 27 Li (10.1016/j.yexcr.2021.112597_bib52) 2015; 100 Alves (10.1016/j.yexcr.2021.112597_bib3) 2020 Zhang (10.1016/j.yexcr.2021.112597_bib61) 2018; 52 Saad (10.1016/j.yexcr.2021.112597_bib14) 2016; 6 Adu-Gyamfi (10.1016/j.yexcr.2021.112597_bib6) 2020; 28 Pollheimer (10.1016/j.yexcr.2021.112597_bib7) 2018; 9 Poli (10.1016/j.yexcr.2021.112597_bib11) 2018; 104 Yang (10.1016/j.yexcr.2021.112597_bib54) 2014; 21 Cheng (10.1016/j.yexcr.2021.112597_bib48) 2017; 158 Wang (10.1016/j.yexcr.2021.112597_bib17) 2017; 7 Davies J (10.1016/j.yexcr.2021.112597_bib37) 2016; 10 Marinello (10.1016/j.yexcr.2021.112597_bib24) 2020; 34 Groen (10.1016/j.yexcr.2021.112597_bib27) 2015; 26 Lewinska (10.1016/j.yexcr.2021.112597_bib28) 2017; 12 Park (10.1016/j.yexcr.2021.112597_bib13) 2014; 44 Peng (10.1016/j.yexcr.2021.112597_bib39) 2015; 100 Ko (10.1016/j.yexcr.2021.112597_bib42) 2016; 57 Li (10.1016/j.yexcr.2021.112597_bib51) 2014; 99 Ma (10.1016/j.yexcr.2021.112597_bib2) 2020 Jauniaux (10.1016/j.yexcr.2021.112597_bib63) 2000; 157 Lamb (10.1016/j.yexcr.2021.112597_bib15) 2020; 9 Luo (10.1016/j.yexcr.2021.112597_bib31) 2015; 73 Brki (10.1016/j.yexcr.2021.112597_bib8) 2018; 26 Ridder (10.1016/j.yexcr.2021.112597_bib32) 2019; 20 Toy (10.1016/j.yexcr.2021.112597_bib64) 2010; 69 Chen (10.1016/j.yexcr.2021.112597_bib55) 2010; 299 Li (10.1016/j.yexcr.2021.112597_bib25) 2019; 82 Hou (10.1016/j.yexcr.2021.112597_bib12) 2009; 2 Hanker (10.1016/j.yexcr.2021.112597_bib30) 2013; 33 Liu (10.1016/j.yexcr.2021.112597_bib34) 2020; 2020 Zuo (10.1016/j.yexcr.2021.112597_bib49) 2014; 8 Thompson (10.1016/j.yexcr.2021.112597_bib56) 2015; 5 Soundararajan (10.1016/j.yexcr.2021.112597_bib33) 2004; 2 Xu (10.1016/j.yexcr.2021.112597_bib29) 2017; 95 Zhao (10.1016/j.yexcr.2021.112597_bib62) 2014; 74 Vićovac (10.1016/j.yexcr.2021.112597_bib36) 1996; 156 Gao (10.1016/j.yexcr.2021.112597_bib21) 2019; 27 Duzyj (10.1016/j.yexcr.2021.112597_bib38) 2015; 36 Genbacev (10.1016/j.yexcr.2021.112597_bib57) 1997; 277 Yamanaka-Tatematsu (10.1016/j.yexcr.2021.112597_bib59) 2013; 8 Gao (10.1016/j.yexcr.2021.112597_bib40) 2019; 27 Naziroglu (10.1016/j.yexcr.2021.112597_bib65) 2000; 18 Bojić-Trbojević (10.1016/j.yexcr.2021.112597_bib5) 2019; 9 Fitzgerald (10.1016/j.yexcr.2021.112597_bib43) 2008; 14 Suman (10.1016/j.yexcr.2021.112597_bib45) 2013; 2 Adu-Gyamfi (10.1016/j.yexcr.2021.112597_bib9) 2020; 102 Wang (10.1016/j.yexcr.2021.112597_bib18) 2017; 41 Lia (10.1016/j.yexcr.2021.112597_bib20) 2018; 710061 Chung (10.1016/j.yexcr.2021.112597_bib44) 1997; 17 Cheng (10.1016/j.yexcr.2021.112597_bib50) 2013; 288 Alam (10.1016/j.yexcr.2021.112597_bib41) 2012; 12 Peng (10.1016/j.yexcr.2021.112597_bib60) 2015; 9 Liu (10.1016/j.yexcr.2021.112597_bib19) 2016; 7 Loukil (10.1016/j.yexcr.2021.112597_bib23) 2015; 6 Alao (10.1016/j.yexcr.2021.112597_bib22) 2007; 6 Chandrasekaran (10.1016/j.yexcr.2021.112597_bib10) 2019; 15 Kolundžić (10.1016/j.yexcr.2021.112597_bib4) 2011; 6 Shih (10.1016/j.yexcr.2021.112597_bib53) 2019; 33 Moser (10.1016/j.yexcr.2021.112597_bib46) 2017; 147
References_xml	– volume: 17 start-page: 6508 year: 1997 Nov end-page: 6516 ident: bib44 article-title: STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation publication-title: Mol. Cell Biol. – volume: 5 start-page: 79 year: 2015 Sep 15 ident: bib56 article-title: Intrauterine hypoxia: clinical consequences and therapeutic perspectives publication-title: Res. Rep. Neonatol. – volume: 12 start-page: 32 year: 2012 Jan 20 ident: bib41 article-title: Fascin overexpression promotes neoplastic progression in oral squamous cell carcinoma publication-title: BMC Canc. – volume: 26 start-page: 1901 year: 2015 May 15 end-page: 1917 ident: bib27 article-title: Prostaglandins regulate nuclear localization of Fascin and its function in nucleolar architecture publication-title: Mol. Biol. Cell – volume: 21 start-page: 72 year: 2014 Jan 30 end-page: 81 ident: bib54 article-title: Downregulated Krüppel-like factor 8 is involved in decreased trophoblast invasion under hypoxia-reoxygenation conditions publication-title: Reprod. Sci. – volume: 156 start-page: 202 year: 1996 Jan 1 end-page: 216 ident: bib36 article-title: Epithelial-mesenchymal transition during trophoblast differentiation publication-title: Cells Tissues Organs – volume: 6 year: 2011 Dec 8 ident: bib4 article-title: Galectin-1 is part of human trophoblast invasion machinery - a functional study in vitro publication-title: PloS One – volume: 8 start-page: 76605 year: 2013 Oct 3 ident: bib59 article-title: Autophagy induced by HIF1α overexpression supports trophoblast invasion by supplying cellular energy publication-title: PloS One – volume: 57 start-page: 761 year: 2016 May 1 end-page: 768 ident: bib42 article-title: STAT3 and ERK signaling pathways are implicated in the invasion activity by oncostatin M through induction of matrix metalloproteinases 2 and 9 publication-title: Yonsei Med. J. – volume: 7 start-page: 12603 year: 2016 Dec 22 ident: bib19 article-title: Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation publication-title: Nat. Commun. – volume: 95 start-page: 1112 year: 2017 Nov end-page: 1118 ident: bib29 article-title: Long non-coding RNA PCAT-1 contributes to tumorigenesis by regulating FSCN1 via miR-145-5p in prostate cancer publication-title: Biomed. Pharmacother. – volume: 8 start-page: 2187 year: 2014 Nov 1 end-page: 2192 ident: bib49 article-title: Effects of transforming growth factor-β1 on the proliferation and invasion of the HTR-8/SVneo cell line publication-title: Oncol Lett – volume: 6 start-page: 346 year: 2015 ident: bib23 article-title: Cyclin A2: at the crossroads of cell cycle and cell invasion publication-title: World J. Biol. Chem. – volume: 20 year: 2019 Jul 1 ident: bib32 article-title: Preeclampsia: the relationship between uterine artery blood flow and trophoblast function publication-title: Int. J. Mol. Sci. – volume: 69 start-page: 122 year: 2010 Mar end-page: 127 ident: bib64 article-title: Decreased serum prolidase activity and increased oxidative stress in early pregnancy loss publication-title: Gynecol. Obstet. Invest. – start-page: 8 year: 2020 Mar 13 ident: bib2 article-title: Upregulation of RND3 affects trophoblast proliferation, apoptosis, and migration at the maternal-fetal interface publication-title: Front Cell Dev Biol – volume: 14 start-page: 377 year: 2019 Mar 1 end-page: 387 ident: bib1 article-title: The attenuation of trophoblast invasion caused by the downregulation of EZH2 is involved in the pathogenesis of human recurrent miscarriage publication-title: Mol. Ther. Nucleic Acids – volume: 36 start-page: 645 year: 2015 Jun 1 end-page: 651 ident: bib38 article-title: The invasive phenotype of placenta accreta extravillous trophoblasts associates with loss of E-cadherin publication-title: Placenta – volume: 100 start-page: E1415 year: 2015 Nov 1 end-page: E1427 ident: bib52 article-title: Activin A increases human trophoblast invasion by inducing SNAIL-mediated MMP2 up-regulation through ALK4 publication-title: J. Clin. Endocrinol. Metab. – volume: 2 year: 2013 Oct 16 ident: bib45 article-title: LIF-STAT signaling and trophoblast biology publication-title: JAK-STAT – volume: 44 start-page: 637 year: 2014 Mar end-page: 646 ident: bib13 article-title: Fascin1 expression in high-grade serous ovarian carcinoma is a prognostic marker and knockdown of fascin1 suppresses the proliferation of ovarian cancer cells publication-title: Int. J. Oncol. – volume: 100 start-page: 13 year: 2020 Oct 1 end-page: 23 ident: bib16 article-title: Stomatin-like protein 2 (SLP2) regulates the proliferation and invasion of trophoblast cells by modulating mitochondrial functions publication-title: Placenta – volume: 27 start-page: 365 year: 2019 Feb 6 end-page: 379 ident: bib40 article-title: Promoter methylation-regulated miR-145-5p inhibits laryngeal squamous cell carcinoma progression by targeting FSCN1 publication-title: Mol. Ther. – volume: 26 start-page: 2189 year: 2018 Sep 5 end-page: 2205 ident: bib8 article-title: MicroRNA-218-5p promotes endovascular trophoblast differentiation and spiral artery remodeling publication-title: Mol. Ther. – volume: 15 year: 2019 Jul 1 ident: bib10 article-title: Remarkable structural transformations of actin bundles are driven by their initial polarity, motor activity, crosslinking, and filament treadmilling publication-title: PLoS Comput. Biol. – start-page: NBK560521 year: 2020 ident: bib3 article-title: Spontaneous Abortion – volume: 277 start-page: 1669 year: 1997 Sep 12 end-page: 1672 ident: bib57 article-title: Regulation of human placental development by oxygen tension publication-title: Science – volume: 9 start-page: 1 year: 2019 Dec 1 end-page: 15 ident: bib5 article-title: Human trophoblast requires galectin-3 for cell migration and invasion publication-title: Sci. Rep. – volume: 2020 start-page: 1 year: 2020 Oct 19 end-page: 8 ident: bib34 article-title: Expression of SASH1 in preeclampsia and its effects on human trophoblast publication-title: BioMed Res. Int. – volume: 104 start-page: 1712 year: 2018 Nov 23 end-page: 1724 ident: bib11 article-title: Fascin-1 is a novel prognostic biomarker associated with tumor invasiveness in adrenocortical carcinoma publication-title: J. Clin. Endocrinol. Metab. – volume: 33 start-page: 371 year: 2013 Feb end-page: 377 ident: bib30 article-title: Prognostic impact of fascin-1 (FSCN1) in epithelial ovarian cancer publication-title: Anticancer Res. – volume: 33 start-page: 6281 year: 2019 May 1 end-page: 6295 ident: bib53 article-title: Unveiling the role of microRNA-7 in linking TGF-β-Smad-mediated epithelial-mesenchymal transition with negative regulation of trophoblast invasion publication-title: Faseb. J. – volume: 2 start-page: 843 year: 2009 Jul 22 end-page: 849 ident: bib12 article-title: Fascin overexpression is regulated by the transactivation of the promoter but not by its hypomethylation in esophageal squamous cell carcinoma publication-title: Mol. Med. Rep. – volume: 21 start-page: 443 year: 2000 Jul 1 end-page: 450 ident: bib58 article-title: Adriana and luisa castellucci award lecture 1999: role of oxygen in the regulation of trophoblast gene expression and invasion publication-title: Placenta – volume: 73 start-page: 75 year: 2015 Jul end-page: 79 ident: bib31 article-title: The clinical significance of FSCN1 in non-small cell lung cancer publication-title: Biomed. Pharmacother. – volume: 18 start-page: 169 year: 2000 Sep end-page: 173 ident: bib65 article-title: Antioxidants and lipid peroxidation status in the blood of patients with alopecia publication-title: Cell Biochem. Funct. – volume: 75 start-page: 361 year: 2016 Mar 1 end-page: 371 ident: bib35 article-title: Cell signaling pathways involved during invasion and syncytialization of trophoblast cells publication-title: Am. J. Reprod. Immunol. – volume: 10 start-page: 310 year: 2016 May 3 end-page: 321 ident: bib37 article-title: Epithelial-mesenchymal transition during extravillous trophoblast differentiation publication-title: Cell Adhes. Migrat. – volume: 7 start-page: 15887 year: 2017 Nov 21 ident: bib17 article-title: FSCN1 gene polymorphisms: biomarkers for the development and progression of breast cancer publication-title: Sci. Rep. – volume: 34 start-page: 14182 year: 2020 Nov 9 end-page: 14199 ident: bib24 article-title: Perfluorobutane sulfonate exposure disrupted human placental cytotrophoblast cell proliferation and invasion involving in dysregulating preeclampsia related genes publication-title: Faseb. J. – volume: 41 start-page: 833 year: 2017 Aug end-page: 841 ident: bib18 article-title: is upregulated by SNAI2 and promotes epithelial to mesenchymal transition in head and neck squamous cell carcinoma publication-title: Cell Biol. Int. – volume: 295 start-page: 169 year: 2000 May 1 end-page: 177 ident: bib66 article-title: Antioxidant defence in recurrent abortion publication-title: Clin. Chim. Acta – volume: 9 start-page: 1271 year: 2015 end-page: 1276 ident: bib60 article-title: Knockdown of autophagy-related gene LC3 enhances the sensitivity of HepG2 cells to epirubicin publication-title: Exp Ther Med – volume: 288 start-page: 33181 year: 2013 Nov 15 end-page: 33192 ident: bib50 article-title: Transforming growth factor-β1 inhibits trophoblast cell invasion by inducing snail-mediated down-regulation of vascular endothelial-cadherin protein publication-title: J. Biol. Chem. – volume: 99 start-page: E2216 year: 2014 Nov 1 end-page: E2225 ident: bib51 article-title: AB increase human trophoblast cell invasion by up-regulating N-cadherin publication-title: J. Clin. Endocrinol. Metab. – volume: 6 start-page: 36699 year: 2016 Dec 7 ident: bib14 article-title: Insights into a novel nuclear function for Fascin in the regulation of the amino-acid transporter SLC3A2 publication-title: Sci. Rep. – volume: 28 start-page: 305 year: 2020 end-page: 320 ident: bib6 article-title: The involvement of cell adhesion molecules, tight junctions, and gap junctions in human placentation publication-title: Reprod. Sci. – volume: 27 start-page: 2965 year: 2016 Oct 1 end-page: 2979 ident: bib26 article-title: Fascin regulates nuclear actin during Drosophila oogenesis publication-title: Mol. Biol. Cell – volume: 147 start-page: 353 year: 2017 Mar 1 end-page: 366 ident: bib46 article-title: Extravillous trophoblasts invade more than uterine arteries: evidence for the invasion of uterine veins publication-title: Histochem. Cell Biol. – volume: 12 start-page: 469 year: 2017 Aug 1 end-page: 482 ident: bib28 article-title: Phytochemical-induced nucleolar stress results in the inhibition of breast cancer cell proliferation publication-title: Redox Biol – volume: 710061 start-page: 1766 year: 2018 end-page: 1777 ident: bib20 article-title: FSCN1 promotes epithelial-mesenchymal transition through increasing Snail1 in ovarian cancer cells publication-title: Cell. Physiol. Biochem. – volume: 82 year: 2019 Jul 1 ident: bib25 article-title: Downregulation of CCNA2 disturbs trophoblast migration, proliferation, and apoptosis during the pathogenesis of recurrent miscarriage publication-title: Am. J. Reprod. Immunol. – volume: 27 start-page: 1 year: 2019 end-page: 15 ident: bib21 article-title: Promoter methylation-regulated miR-145-5p inhibits laryngeal squamous cell carcinoma progression by targeting FSCN1 publication-title: Mol. Ther. – volume: 158 start-page: 3620 year: 2017 Oct 1 end-page: 3628 ident: bib48 article-title: TGF-β1 inhibits human trophoblast cell invasion by upregulating connective tissue growth factor expression publication-title: Endocrinology – volume: 6 start-page: 24 year: 2007 Apr 2 ident: bib22 article-title: The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention publication-title: Mol. Canc. – volume: 157 start-page: 2111 year: 2000 end-page: 2122 ident: bib63 article-title: Onset of maternal arterial blood flow and placental oxidative stress: a possible factor in human early pregnancy failure publication-title: Am. J. Pathol. – volume: 102 start-page: 18 year: 2020 Feb 12 end-page: 26 ident: bib47 article-title: Regulation of placentation by the transforming growth factor beta superfamily publication-title: Biol. Reprod. – volume: 52 start-page: 1455 year: 2018 Mar 20 end-page: 1464 ident: bib61 article-title: FSCN-1 increases doxorubicin resistance in hepatocellular carcinoma through promotion of epithelial-mesenchymal transition publication-title: Int. J. Oncol. – volume: 74 start-page: 2455 year: 2014 Jan 5 end-page: 2464 ident: bib62 article-title: Hypoxia-Inducible factor-1 promotes pancreatic ductal adenocarcinoma invasion and metastasis by activating transcription of the actin-Bundling protein fascin publication-title: Canc. Res. – volume: 2 start-page: 15 year: 2004 Mar 25 ident: bib33 article-title: Trophoblast “pseudo-tumorigenesis”: significance and contributory factors publication-title: Reprod. Biol. Endocrinol. – volume: 299 year: 2010 Nov ident: bib55 article-title: Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts publication-title: Am. J. Physiol. Cell Physiol. – volume: 9 start-page: 2597 year: 2018 Nov 13 ident: bib7 article-title: Regulation of placental extravillous trophoblasts by the maternal uterine environment publication-title: Front. Immunol. – volume: 102 start-page: 9 year: 2020 Feb 12 end-page: 17 ident: bib9 article-title: The interplay between thyroid hormones and the placenta: a comprehensive review publication-title: Biol. Reprod. – volume: 9 start-page: 403 year: 2020 Nov 17 ident: bib15 article-title: Fascin in cell migration: more than an actin bundling protein publication-title: Biology – volume: 100 start-page: E19 year: 2015 Jan 1 end-page: E29 ident: bib39 article-title: Gonadotropin releasing hormone regulates human trophoblastic cell invasion via TWIST induced ncadherin expression publication-title: J. Clin. Endocrinol. Metab. – volume: 14 start-page: 335 year: 2008 Jul end-page: 344 ident: bib43 article-title: Trophoblast invasion: the role of intracellular cytokine signalling via signal transducer and activator of transcription 3 (STAT3) publication-title: Hum. Reprod. Update – volume: 6 start-page: 346 issue: 4 year: 2015 ident: 10.1016/j.yexcr.2021.112597_bib23 article-title: Cyclin A2: at the crossroads of cell cycle and cell invasion publication-title: World J. Biol. Chem. doi: 10.4331/wjbc.v6.i4.346 – volume: 36 start-page: 645 issue: 6 year: 2015 ident: 10.1016/j.yexcr.2021.112597_bib38 article-title: The invasive phenotype of placenta accreta extravillous trophoblasts associates with loss of E-cadherin publication-title: Placenta doi: 10.1016/j.placenta.2015.04.001 – volume: 9 start-page: 2597 issue: NOV year: 2018 ident: 10.1016/j.yexcr.2021.112597_bib7 article-title: Regulation of placental extravillous trophoblasts by the maternal uterine environment publication-title: Front. Immunol. doi: 10.3389/fimmu.2018.02597 – volume: 27 start-page: 1 issue: 1 year: 2019 ident: 10.1016/j.yexcr.2021.112597_bib21 article-title: Promoter methylation-regulated miR-145-5p inhibits laryngeal squamous cell carcinoma progression by targeting FSCN1 publication-title: Mol. Ther. – volume: 52 start-page: 1455 year: 2018 ident: 10.1016/j.yexcr.2021.112597_bib61 article-title: FSCN-1 increases doxorubicin resistance in hepatocellular carcinoma through promotion of epithelial-mesenchymal transition publication-title: Int. J. Oncol. – volume: 100 start-page: E1415 issue: 11 year: 2015 ident: 10.1016/j.yexcr.2021.112597_bib52 article-title: Activin A increases human trophoblast invasion by inducing SNAIL-mediated MMP2 up-regulation through ALK4 publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2015-2134 – volume: 10 start-page: 310 issue: 3 year: 2016 ident: 10.1016/j.yexcr.2021.112597_bib37 article-title: Epithelial-mesenchymal transition during extravillous trophoblast differentiation publication-title: Cell Adhes. Migrat. doi: 10.1080/19336918.2016.1170258 – volume: 100 start-page: E19 issue: 1 year: 2015 ident: 10.1016/j.yexcr.2021.112597_bib39 article-title: Gonadotropin releasing hormone regulates human trophoblastic cell invasion via TWIST induced ncadherin expression publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2014-1897 – volume: 75 start-page: 361 issue: 3 year: 2016 ident: 10.1016/j.yexcr.2021.112597_bib35 article-title: Cell signaling pathways involved during invasion and syncytialization of trophoblast cells publication-title: Am. J. Reprod. Immunol. doi: 10.1111/aji.12436 – volume: 17 start-page: 6508 issue: 11 year: 1997 ident: 10.1016/j.yexcr.2021.112597_bib44 article-title: STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation publication-title: Mol. Cell Biol. doi: 10.1128/MCB.17.11.6508 – volume: 21 start-page: 72 issue: 1 year: 2014 ident: 10.1016/j.yexcr.2021.112597_bib54 article-title: Downregulated Krüppel-like factor 8 is involved in decreased trophoblast invasion under hypoxia-reoxygenation conditions publication-title: Reprod. Sci. doi: 10.1177/1933719113488448 – volume: 2 start-page: 15 year: 2004 ident: 10.1016/j.yexcr.2021.112597_bib33 article-title: Trophoblast “pseudo-tumorigenesis”: significance and contributory factors publication-title: Reprod. Biol. Endocrinol. doi: 10.1186/1477-7827-2-15 – volume: 299 issue: 5 year: 2010 ident: 10.1016/j.yexcr.2021.112597_bib55 article-title: Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts publication-title: Am. J. Physiol. Cell Physiol. doi: 10.1152/ajpcell.00154.2010 – volume: 20 issue: 13 year: 2019 ident: 10.1016/j.yexcr.2021.112597_bib32 article-title: Preeclampsia: the relationship between uterine artery blood flow and trophoblast function publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms20133263 – volume: 2020 start-page: 1 year: 2020 ident: 10.1016/j.yexcr.2021.112597_bib34 article-title: Expression of SASH1 in preeclampsia and its effects on human trophoblast publication-title: BioMed Res. Int. – volume: 41 start-page: 833 issue: 8 year: 2017 ident: 10.1016/j.yexcr.2021.112597_bib18 article-title: FSCN1 is upregulated by SNAI2 and promotes epithelial to mesenchymal transition in head and neck squamous cell carcinoma publication-title: Cell Biol. Int. doi: 10.1002/cbin.10786 – volume: 27 start-page: 365 issue: 2 year: 2019 ident: 10.1016/j.yexcr.2021.112597_bib40 article-title: Promoter methylation-regulated miR-145-5p inhibits laryngeal squamous cell carcinoma progression by targeting FSCN1 publication-title: Mol. Ther. doi: 10.1016/j.ymthe.2018.09.018 – volume: 44 start-page: 637 issue: 3 year: 2014 ident: 10.1016/j.yexcr.2021.112597_bib13 article-title: Fascin1 expression in high-grade serous ovarian carcinoma is a prognostic marker and knockdown of fascin1 suppresses the proliferation of ovarian cancer cells publication-title: Int. J. Oncol. doi: 10.3892/ijo.2013.2232 – volume: 710061 start-page: 1766 issue: 49 year: 2018 ident: 10.1016/j.yexcr.2021.112597_bib20 article-title: FSCN1 promotes epithelial-mesenchymal transition through increasing Snail1 in ovarian cancer cells publication-title: Cell. Physiol. Biochem. doi: 10.1159/000493622 – volume: 34 start-page: 14182 issue: 11 year: 2020 ident: 10.1016/j.yexcr.2021.112597_bib24 article-title: Perfluorobutane sulfonate exposure disrupted human placental cytotrophoblast cell proliferation and invasion involving in dysregulating preeclampsia related genes publication-title: Faseb. J. doi: 10.1096/fj.202000716RR – volume: 74 start-page: 2455 issue: 9 year: 2014 ident: 10.1016/j.yexcr.2021.112597_bib62 article-title: Hypoxia-Inducible factor-1 promotes pancreatic ductal adenocarcinoma invasion and metastasis by activating transcription of the actin-Bundling protein fascin publication-title: Canc. Res. doi: 10.1158/0008-5472.CAN-13-3009 – volume: 288 start-page: 33181 issue: 46 year: 2013 ident: 10.1016/j.yexcr.2021.112597_bib50 article-title: Transforming growth factor-β1 inhibits trophoblast cell invasion by inducing snail-mediated down-regulation of vascular endothelial-cadherin protein publication-title: J. Biol. Chem. doi: 10.1074/jbc.M113.488866 – volume: 8 start-page: 2187 issue: 5 year: 2014 ident: 10.1016/j.yexcr.2021.112597_bib49 article-title: Effects of transforming growth factor-β1 on the proliferation and invasion of the HTR-8/SVneo cell line publication-title: Oncol Lett doi: 10.3892/ol.2014.2451 – volume: 147 start-page: 353 issue: 3 year: 2017 ident: 10.1016/j.yexcr.2021.112597_bib46 article-title: Extravillous trophoblasts invade more than uterine arteries: evidence for the invasion of uterine veins publication-title: Histochem. Cell Biol. doi: 10.1007/s00418-016-1509-5 – volume: 156 start-page: 202 issue: 3 year: 1996 ident: 10.1016/j.yexcr.2021.112597_bib36 article-title: Epithelial-mesenchymal transition during trophoblast differentiation publication-title: Cells Tissues Organs doi: 10.1159/000147847 – volume: 9 start-page: 1 issue: 1 year: 2019 ident: 10.1016/j.yexcr.2021.112597_bib5 article-title: Human trophoblast requires galectin-3 for cell migration and invasion publication-title: Sci. Rep. doi: 10.1038/s41598-018-38374-w – volume: 26 start-page: 2189 issue: 9 year: 2018 ident: 10.1016/j.yexcr.2021.112597_bib8 article-title: MicroRNA-218-5p promotes endovascular trophoblast differentiation and spiral artery remodeling publication-title: Mol. Ther. doi: 10.1016/j.ymthe.2018.07.009 – volume: 9 start-page: 403 issue: 11 year: 2020 ident: 10.1016/j.yexcr.2021.112597_bib15 article-title: Fascin in cell migration: more than an actin bundling protein publication-title: Biology doi: 10.3390/biology9110403 – volume: 100 start-page: 13 year: 2020 ident: 10.1016/j.yexcr.2021.112597_bib16 article-title: Stomatin-like protein 2 (SLP2) regulates the proliferation and invasion of trophoblast cells by modulating mitochondrial functions publication-title: Placenta doi: 10.1016/j.placenta.2020.07.008 – volume: 69 start-page: 122 issue: 2 year: 2010 ident: 10.1016/j.yexcr.2021.112597_bib64 article-title: Decreased serum prolidase activity and increased oxidative stress in early pregnancy loss publication-title: Gynecol. Obstet. Invest. doi: 10.1159/000262608 – volume: 14 start-page: 377 year: 2019 ident: 10.1016/j.yexcr.2021.112597_bib1 article-title: The attenuation of trophoblast invasion caused by the downregulation of EZH2 is involved in the pathogenesis of human recurrent miscarriage publication-title: Mol. Ther. Nucleic Acids doi: 10.1016/j.omtn.2018.12.011 – volume: 15 issue: 7 year: 2019 ident: 10.1016/j.yexcr.2021.112597_bib10 article-title: Remarkable structural transformations of actin bundles are driven by their initial polarity, motor activity, crosslinking, and filament treadmilling publication-title: PLoS Comput. Biol. doi: 10.1371/journal.pcbi.1007156 – volume: 2 issue: 4 year: 2013 ident: 10.1016/j.yexcr.2021.112597_bib45 article-title: LIF-STAT signaling and trophoblast biology publication-title: JAK-STAT doi: 10.4161/jkst.25155 – volume: 5 start-page: 79 year: 2015 ident: 10.1016/j.yexcr.2021.112597_bib56 article-title: Intrauterine hypoxia: clinical consequences and therapeutic perspectives publication-title: Res. Rep. Neonatol. – volume: 18 start-page: 169 issue: 3 year: 2000 ident: 10.1016/j.yexcr.2021.112597_bib65 article-title: Antioxidants and lipid peroxidation status in the blood of patients with alopecia publication-title: Cell Biochem. Funct. doi: 10.1002/1099-0844(200009)18:3<169::AID-CBF870>3.0.CO;2-T – volume: 57 start-page: 761 issue: 3 year: 2016 ident: 10.1016/j.yexcr.2021.112597_bib42 article-title: STAT3 and ERK signaling pathways are implicated in the invasion activity by oncostatin M through induction of matrix metalloproteinases 2 and 9 publication-title: Yonsei Med. J. doi: 10.3349/ymj.2016.57.3.761 – volume: 157 start-page: 2111 issue: 6 year: 2000 ident: 10.1016/j.yexcr.2021.112597_bib63 article-title: Onset of maternal arterial blood flow and placental oxidative stress: a possible factor in human early pregnancy failure publication-title: Am. J. Pathol. doi: 10.1016/S0002-9440(10)64849-3 – volume: 7 start-page: 15887 issue: 1 year: 2017 ident: 10.1016/j.yexcr.2021.112597_bib17 article-title: FSCN1 gene polymorphisms: biomarkers for the development and progression of breast cancer publication-title: Sci. Rep. doi: 10.1038/s41598-017-16196-6 – volume: 27 start-page: 2965 issue: 19 year: 2016 ident: 10.1016/j.yexcr.2021.112597_bib26 article-title: Fascin regulates nuclear actin during Drosophila oogenesis publication-title: Mol. Biol. Cell doi: 10.1091/mbc.E15-09-0634 – volume: 33 start-page: 371 issue: 2 year: 2013 ident: 10.1016/j.yexcr.2021.112597_bib30 article-title: Prognostic impact of fascin-1 (FSCN1) in epithelial ovarian cancer publication-title: Anticancer Res. – volume: 33 start-page: 6281 issue: 5 year: 2019 ident: 10.1016/j.yexcr.2021.112597_bib53 article-title: Unveiling the role of microRNA-7 in linking TGF-β-Smad-mediated epithelial-mesenchymal transition with negative regulation of trophoblast invasion publication-title: Faseb. J. doi: 10.1096/fj.201801898RR – volume: 7 start-page: 12603 issue: 1 year: 2016 ident: 10.1016/j.yexcr.2021.112597_bib19 article-title: Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation publication-title: Nat. Commun. doi: 10.1038/ncomms12603 – volume: 6 start-page: 36699 issue: 1 year: 2016 ident: 10.1016/j.yexcr.2021.112597_bib14 article-title: Insights into a novel nuclear function for Fascin in the regulation of the amino-acid transporter SLC3A2 publication-title: Sci. Rep. doi: 10.1038/srep36699 – volume: 104 start-page: 1712 issue: 5 year: 2018 ident: 10.1016/j.yexcr.2021.112597_bib11 article-title: Fascin-1 is a novel prognostic biomarker associated with tumor invasiveness in adrenocortical carcinoma publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2018-01717 – volume: 12 start-page: 469 year: 2017 ident: 10.1016/j.yexcr.2021.112597_bib28 article-title: Phytochemical-induced nucleolar stress results in the inhibition of breast cancer cell proliferation publication-title: Redox Biol doi: 10.1016/j.redox.2017.03.014 – volume: 295 start-page: 169 issue: 1–2 year: 2000 ident: 10.1016/j.yexcr.2021.112597_bib66 article-title: Antioxidant defence in recurrent abortion publication-title: Clin. Chim. Acta doi: 10.1016/S0009-8981(99)00255-7 – volume: 26 start-page: 1901 issue: 10 year: 2015 ident: 10.1016/j.yexcr.2021.112597_bib27 article-title: Prostaglandins regulate nuclear localization of Fascin and its function in nucleolar architecture publication-title: Mol. Biol. Cell doi: 10.1091/mbc.E14-09-1384 – volume: 6 issue: 12 year: 2011 ident: 10.1016/j.yexcr.2021.112597_bib4 article-title: Galectin-1 is part of human trophoblast invasion machinery - a functional study in vitro publication-title: PloS One doi: 10.1371/journal.pone.0028514 – volume: 2 start-page: 843 issue: 5 year: 2009 ident: 10.1016/j.yexcr.2021.112597_bib12 article-title: Fascin overexpression is regulated by the transactivation of the promoter but not by its hypomethylation in esophageal squamous cell carcinoma publication-title: Mol. Med. Rep. – volume: 14 start-page: 335 issue: 4 year: 2008 ident: 10.1016/j.yexcr.2021.112597_bib43 article-title: Trophoblast invasion: the role of intracellular cytokine signalling via signal transducer and activator of transcription 3 (STAT3) publication-title: Hum. Reprod. Update doi: 10.1093/humupd/dmn010 – volume: 95 start-page: 1112 year: 2017 ident: 10.1016/j.yexcr.2021.112597_bib29 article-title: Long non-coding RNA PCAT-1 contributes to tumorigenesis by regulating FSCN1 via miR-145-5p in prostate cancer publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2017.09.019 – volume: 21 start-page: 443 issue: 5–6 year: 2000 ident: 10.1016/j.yexcr.2021.112597_bib58 article-title: Adriana and luisa castellucci award lecture 1999: role of oxygen in the regulation of trophoblast gene expression and invasion publication-title: Placenta doi: 10.1053/plac.2000.0543 – volume: 102 start-page: 9 issue: 1 year: 2020 ident: 10.1016/j.yexcr.2021.112597_bib9 article-title: The interplay between thyroid hormones and the placenta: a comprehensive review publication-title: Biol. Reprod. – volume: 6 start-page: 24 year: 2007 ident: 10.1016/j.yexcr.2021.112597_bib22 article-title: The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention publication-title: Mol. Canc. doi: 10.1186/1476-4598-6-24 – volume: 82 issue: 1 year: 2019 ident: 10.1016/j.yexcr.2021.112597_bib25 article-title: Downregulation of CCNA2 disturbs trophoblast migration, proliferation, and apoptosis during the pathogenesis of recurrent miscarriage publication-title: Am. J. Reprod. Immunol. doi: 10.1111/aji.13144 – volume: 158 start-page: 3620 issue: 10 year: 2017 ident: 10.1016/j.yexcr.2021.112597_bib48 article-title: TGF-β1 inhibits human trophoblast cell invasion by upregulating connective tissue growth factor expression publication-title: Endocrinology doi: 10.1210/en.2017-00536 – volume: 8 start-page: 76605 issue: 10 year: 2013 ident: 10.1016/j.yexcr.2021.112597_bib59 article-title: Autophagy induced by HIF1α overexpression supports trophoblast invasion by supplying cellular energy publication-title: PloS One doi: 10.1371/journal.pone.0076605 – start-page: 8 year: 2020 ident: 10.1016/j.yexcr.2021.112597_bib2 article-title: Upregulation of RND3 affects trophoblast proliferation, apoptosis, and migration at the maternal-fetal interface publication-title: Front Cell Dev Biol – volume: 99 start-page: E2216 issue: 11 year: 2014 ident: 10.1016/j.yexcr.2021.112597_bib51 article-title: AB increase human trophoblast cell invasion by up-regulating N-cadherin publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2014-2118 – volume: 277 start-page: 1669 issue: 5332 year: 1997 ident: 10.1016/j.yexcr.2021.112597_bib57 article-title: Regulation of human placental development by oxygen tension publication-title: Science doi: 10.1126/science.277.5332.1669 – volume: 73 start-page: 75 year: 2015 ident: 10.1016/j.yexcr.2021.112597_bib31 article-title: The clinical significance of FSCN1 in non-small cell lung cancer publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2015.05.014 – volume: 102 start-page: 18 issue: 1 year: 2020 ident: 10.1016/j.yexcr.2021.112597_bib47 article-title: Regulation of placentation by the transforming growth factor beta superfamily publication-title: Biol. Reprod. doi: 10.1093/biolre/ioz186 – volume: 12 start-page: 32 year: 2012 ident: 10.1016/j.yexcr.2021.112597_bib41 article-title: Fascin overexpression promotes neoplastic progression in oral squamous cell carcinoma publication-title: BMC Canc. doi: 10.1186/1471-2407-12-32 – volume: 28 start-page: 305 issue: 2 year: 2020 ident: 10.1016/j.yexcr.2021.112597_bib6 article-title: The involvement of cell adhesion molecules, tight junctions, and gap junctions in human placentation publication-title: Reprod. Sci. doi: 10.1007/s43032-020-00364-7 – volume: 9 start-page: 1271 issue: 4 year: 2015 ident: 10.1016/j.yexcr.2021.112597_bib60 article-title: Knockdown of autophagy-related gene LC3 enhances the sensitivity of HepG2 cells to epirubicin publication-title: Exp Ther Med doi: 10.3892/etm.2015.2266 – start-page: NBK560521 year: 2020 ident: 10.1016/j.yexcr.2021.112597_bib3
SSID	ssj0008816
Score	2.4289827
Snippet	Inadequate trophoblast proliferation, shallow invasion and exaggerated rate of trophoblast apoptosis are implicated in early recurrent miscarriage (ERM).... Highlights: • Fascin is downregulated in the placentae of pregnancies complicated by early recurrent miscarriage. • Knockdown of fascin decreased HTR-8/SVneo...
SourceID	osti proquest pubmed crossref elsevier
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	112597
SubjectTerms	60 APPLIED LIFE SCIENCES ACTIN ANOXIA APOPTOSIS CELL PROLIFERATION Fascin Hypoxia reoxygenation MOLECULES MORPHOLOGY PATHOGENESIS PHOSPHOTRANSFERASES PREGNANCY Recurrent miscarriage TRANSCRIPTION FACTORS Trophoblast
Title	Downregulation of fascin in the first trimester placental villi is associated with early recurrent miscarriage
URI	https://dx.doi.org/10.1016/j.yexcr.2021.112597 https://www.ncbi.nlm.nih.gov/pubmed/33862100 https://www.proquest.com/docview/2514598911 https://www.osti.gov/biblio/23195287
Volume	403
WOSCitedRecordID	wos000645097800012&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1090-2422 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0008816 issn: 0014-4827 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLa6DiReJu50jMlIvJVMudb24zQ6LoKJh4HyFjm-QKeRTr2p_UH8T47txE2pVrEH1CqKkthKcr4eH59-_g5Cb4RiTGoiAlVmJEgHJtEkQhlEmjCRaC60XeX6_TO5uKB5zr52Or-btTCLa1JVdLlkN__V1HAMjG2Wzt7B3L5TOAD7YHTYgtlh-0-Gfwfz6omrMF8Hg5rDOOcZjXoEAV9_ZmT9jUhC37Ky7JrIhcm9mArnvLZZQ01XVgV5YlLzVswJsCH4BJ5lk0g0bFcLMP8I9GspIZ9yNvKOM5ckt0UC_HHLKTjn1Q_N66HUcgjmwfsV_6Xt2WE1Fj9N1Dxap7DP6rUl-VwFX9SoncKIW1Srxi1HaWD0SNtuOQ2TLfw5JwshYuZIvVv-36Uirk5WaimM2mscnayv3lTb_msU9NzEhvZ2VdhOCtNJ4TrZQ_sxyRg4z_3Tj8P8kx_yKbU1dv1zNPJWlki4dS-3hUDdMXj122c6NuK5fIgO6qkKPnUQe4Q6qnqM7rvipasnqNoEGh5r7ICG4QtAwxZo2AMNe6BhCzQ8muI10LABGrZAwx5ouAW0p-jb-fDy7ENQV-8IRELJLFAwcCqaCFZSKmCakEpJQslDnQgdc8rjVNBMSw6-QkkIWnlWJpQTyUiYlVSS5BnqVgDFFwiTUgoFHx6JMo04Z6GAQHagpFZJmSneQ3HzQgtRS9ubCivXxQ5j9tBb3-jGKbvsvnzQWKqog1MXdBaAvd0Nj4xdTSMjyywMfw1awbyKZTGF068bexfmpRrOY6XG82kBM480YxSikR567oDgbzRJ6CCOwvDwbg_xEj1Y__6OUHc2matX6J5YzEbTyTHaIzk9rrH9B-fG2Bg
linkProvider	Elsevier
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Downregulation+of+fascin+in+the+first+trimester+placental+villi+is+associated+with+early+recurrent+miscarriage&rft.jtitle=Experimental+cell+research&rft.au=Lamptey%2C+Jones&rft.au=Li%2C+Fangfang&rft.au=Adu-Gyamfi%2C+Enoch+Appiah&rft.au=Chen%2C+Xue-Mei&rft.date=2021-06-01&rft.issn=0014-4827&rft.volume=403&rft.issue=1&rft.spage=112597&rft_id=info:doi/10.1016%2Fj.yexcr.2021.112597&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_yexcr_2021_112597
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0014-4827&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0014-4827&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0014-4827&client=summon