Synthetic retinal analogues modify the spectral and kinetic characteristics of microbial rhodopsin optogenetic tools

Optogenetic tools have become indispensable in neuroscience to stimulate or inhibit excitable cells by light. Channelrhodopsin-2 (ChR2) variants have been established by mutating the opsin backbone or by mining related algal genomes. As an alternative strategy, we surveyed synthetic retinal analogue...

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Veröffentlicht in:	Nature communications Jg. 5; H. 1; S. 5810
Hauptverfasser:	AzimiHashemi, N., Erbguth, K., Vogt, A., Riemensperger, T., Rauch, E., Woodmansee, D., Nagpal, J., Brauner, M., Sheves, M., Fiala, A., Kattner, L., Trauner, D., Hegemann, P., Gottschalk, A., Liewald, J. F.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 15.12.2014 Nature Publishing Group
Schlagworte:	13/106 14/63 631/1647/2253 631/378/2586 631/92/436 64/11 64/24 9/74 Action Potentials - physiology Algae Animals Animals, Genetically Modified Behavior, Animal Caenorhabditis elegans - chemistry Caenorhabditis elegans - drug effects Caenorhabditis elegans - metabolism Drosophila melanogaster - chemistry Drosophila melanogaster - drug effects Drosophila melanogaster - metabolism Drosophila Proteins - chemistry Genomes HEK293 Cells Helminth Proteins - chemistry Humanities and Social Sciences Humans Insects Larva - chemistry Larva - drug effects Larva - metabolism Light Light intensity multidisciplinary Neurosciences Optogenetics - instrumentation Patch-Clamp Techniques Proteins Recombinant Proteins - chemistry Retinaldehyde - chemistry Retinaldehyde - pharmacology Rhodopsin - chemistry Rhodopsins, Microbial - chemistry Science Science (multidisciplinary) Wavelengths Germany
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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