The role of protein clearance mechanisms in organismal ageing and age-related diseases

Proteins are subject to continuous and complex quality-control mechanisms, which ensure integrity of the proteome. Vilchez et al. review how a demise in these processes, collectively referred to as proteostasis, is linked to organismal ageing and the development of age-associated diseases. The abili...

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Bibliographic Details
Published in:	Nature communications Vol. 5; no. 1; p. 5659
Main Authors:	Vilchez, David, Saez, Isabel, Dillin, Andrew
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 08.12.2014 Nature Publishing Group
Subjects:	13 631/378/1689/364 631/443/7 631/80/474/2085 64 64/11 Aging Alzheimer Disease - metabolism Animals Autophagy Homeostasis Humanities and Social Sciences Humans Huntington Disease - metabolism Insulin - metabolism Lysosomes - metabolism multidisciplinary Neoplasms - metabolism Neurodegenerative Diseases - metabolism Parkinson Disease - metabolism Proteasome Endopeptidase Complex - metabolism Protein Binding Proteins - metabolism Proteome review-article Science Science (multidisciplinary) Somatomedins - metabolism Ubiquitin - metabolism
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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