The role of protein clearance mechanisms in organismal ageing and age-related diseases

Proteins are subject to continuous and complex quality-control mechanisms, which ensure integrity of the proteome. Vilchez et al. review how a demise in these processes, collectively referred to as proteostasis, is linked to organismal ageing and the development of age-associated diseases. The abili...

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Bibliographic Details
Published in:Nature communications Vol. 5; no. 1; p. 5659
Main Authors: Vilchez, David, Saez, Isabel, Dillin, Andrew
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 08.12.2014
Nature Publishing Group
Subjects:
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631/443/7
631/80/474/2085
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64/11
Aging
Alzheimer Disease - metabolism
Animals
Autophagy
Homeostasis
Humanities and Social Sciences
Humans
Huntington Disease - metabolism
Insulin - metabolism
Lysosomes - metabolism
multidisciplinary
Neoplasms - metabolism
Neurodegenerative Diseases - metabolism
Parkinson Disease - metabolism
Proteasome Endopeptidase Complex - metabolism
Protein Binding
Proteins - metabolism
Proteome
review-article
Science
Science (multidisciplinary)
Somatomedins - metabolism
Ubiquitin - metabolism
ISSN:2041-1723, 2041-1723
Online Access:Get full text
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Summary:Proteins are subject to continuous and complex quality-control mechanisms, which ensure integrity of the proteome. Vilchez et al. review how a demise in these processes, collectively referred to as proteostasis, is linked to organismal ageing and the development of age-associated diseases. The ability to maintain a functional proteome, or proteostasis, declines during the ageing process. Damaged and misfolded proteins accumulate with age, impairing cell function and tissue homeostasis. The accumulation of damaged proteins contributes to multiple age-related diseases such as Alzheimer’s, Parkinson’s or Huntington’s disease. Damaged proteins are degraded by the ubiquitin–proteasome system or through autophagy-lysosome, key components of the proteostasis network. Modulation of either proteasome activity or autophagic-lysosomal potential extends lifespan and protects organisms from symptoms associated with proteostasis disorders, suggesting that protein clearance mechanisms are directly linked to ageing and age-associated diseases.
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ISSN:2041-1723
2041-1723
DOI:10.1038/ncomms6659