Silencing of CCR4-NOT complex subunits affects heart structure and function

The identification of genetic variants that predispose individuals to cardiovascular disease and a better understanding of their targets would be highly advantageous. Genome-wide association studies have identified variants that associate with QT-interval length (a measure of myocardial repolarizati...

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Veröffentlicht in:	Disease models & mechanisms Jg. 13; H. 7
Hauptverfasser:	Elmén, Lisa, Volpato, Claudia B., Kervadec, Anaïs, Pineda, Santiago, Kalvakuri, Sreehari, Alayari, Nakissa N., Foco, Luisa, Pramstaller, Peter P., Ocorr, Karen, Rossini, Alessandra, Cammarato, Anthony, Colas, Alexandre R., Hicks, Andrew A., Bodmer, Rolf
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England The Company of Biologists Ltd 20.07.2020 The Company of Biologists
Schlagworte:	Action Potentials Animals Animals, Genetically Modified arrhythmia cardiomyocytes Cardiovascular disease Cell Proliferation Cloning cnot1 Dros drosophila heart Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Exoribonucleases - genetics Exoribonucleases - metabolism Experiments Gene expression Gene Expression Regulation, Developmental Gene Silencing Genetic engineering Genome-Wide Association Study Genomes gwas Haplotypes Heart Heart Rate HeLa Cells hipsc Humans Induced Pluripotent Stem Cells - metabolism Induced Pluripotent Stem Cells - pathology Insects Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Long QT Syndrome - genetics Long QT Syndrome - metabolism Long QT Syndrome - pathology Long QT Syndrome - physiopathology long-qt syndrome Morphogenesis Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Quality control Repressor Proteins - genetics Repressor Proteins - metabolism Ribonucleases - genetics Ribonucleases - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Transcription Factors - genetics Transcription Factors - metabolism GWAS Arrhythmia CNOT1 hiPSC Cardiomyocytes Drosophila heart Long-QT syndrome
ISSN:	1754-8403, 1754-8411, 1754-8411
Online-Zugang:	Volltext
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