Mucus and Ciliated Cells of Human Lung: Splitting Strategies for Particle Methods and 3D Stokes Flows

This proceeding is introducing a fractional step algorithm for diffusion-transport allowing computation of flows with sharp varia- tions of viscosity. This splitting also allows to perform transport with Lagrangian methods and diffusion with Eulerian methods, using hybrid grid-particle formulation....

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Vydané v:Procedia IUTAM Ročník 18; s. 114 - 122
Hlavní autori: Chatelin, R., Poncet, P., Didier, A., Murris-Espin, M., Anne-Archard, D., Thiriet, M.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Elsevier B.V 2015
Elsevier
Predmet:
3D Stokes flows
Biological flows
Complex geometries
Computer Science
Human health and pathology
Life Sciences
Mathematics
Modeling and Simulation
Mucus flows
Non-homogen flows
Numerical Analysis
Particle methods
Pulmonology and respiratory tract
Transport
3D Stokes flows
Complex geometries
Particle methods
Non-homogen flows
Transport
Biological flows
Mucus flows
Mucus flows 1 Context and motivation
ISSN:2210-9838, 2210-9838
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Abstract This proceeding is introducing a fractional step algorithm for diffusion-transport allowing computation of flows with sharp varia- tions of viscosity. This splitting also allows to perform transport with Lagrangian methods and diffusion with Eulerian methods, using hybrid grid-particle formulation. This splitting algorithm is globally second order. It is applied to computation of mucus mo- bility in human lungs, where epithelium ciliated cells are beating. A sufficient mobility is required to have healthy configurations. Our goal is to study the dependency of mucus mobility with respect to its viscosity in order to investigate mechanisms involved in pathologies such as cystic fibrosis.
AbstractList This work is introducing a fractional step algorithm for diffusion-transport allowing computation of flows with sharp variations of viscosity. This splitting also allows to perform transport with Lagrangian methods and diffusion with Eulerian methods, using hybrid grid-particle formulation. This splitting algorithm is globally second order. It is applied to computation of mucus mobility in human lungs, where epithelium ciliated cells are beating. A sufficient mobility is required to have healthy configurations. Our goal is to study the dependency of mucus mobility with respect to its viscosity in order to investigate mechanisms involved in pathologies such as cystic fibrosis. Scientific computing involving phenomena where transport effects are dominant, is still a challenge for realistic modeling of complex flows. Among the most famous problems, one can find Euler and Navier-Stokes equations, in velocity-pressure or velocity-vorticity formulations, with various boundary conditions. Particle and vortex methods are a well-known and efficient tool for this kind of problem. In the present paper we describe some aspects on how to use particle methods in the context of highly viscous flows. The application investigated is the propulsion of pulmonary mucus in human lungs. A meaningful model is 3D Stokes flows with a variable viscosity, depending on concentration of proteins (mucins), itself following a diffusion-transport equation. In additions to this coupling, the mucus film covering lung walls is interacting with epithelium ciliated cells, vibrating in the range of 4 to 20 Hz, as shown on figure 1. In the present study we neglect interactions between mucus and air (proven to be a non-dominant interaction), and visco-elastic effects. The aspect we aim at developing in this article is how to split diffusion and transport in this context.
This proceeding is introducing a fractional step algorithm for diffusion-transport allowing computation of flows with sharp varia- tions of viscosity. This splitting also allows to perform transport with Lagrangian methods and diffusion with Eulerian methods, using hybrid grid-particle formulation. This splitting algorithm is globally second order. It is applied to computation of mucus mo- bility in human lungs, where epithelium ciliated cells are beating. A sufficient mobility is required to have healthy configurations. Our goal is to study the dependency of mucus mobility with respect to its viscosity in order to investigate mechanisms involved in pathologies such as cystic fibrosis.
Author Chatelin, R.
Anne-Archard, D.
Murris-Espin, M.
Didier, A.
Thiriet, M.
Poncet, P.
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  organization: Lab. J-L. Lions, CNRS UMR 7598, UPMC Paris VI, BC 187, 4 place Jussieu, F-75252 Paris
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CitedBy_id crossref_primary_10_1089_jamp_2022_0049
crossref_primary_10_1016_j_jbiomech_2019_109578
Cites_doi 10.1137/090765006
10.1016/0021-9991(85)90006-3
10.1007/978-1-4614-5966-8
10.4103/2045-8932.94838
10.1137/0909050
10.1016/0096-3003(89)90010-6
10.1137/120892921
10.1016/j.jcp.2003.08.025
10.1137/060652877
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Keywords 3D Stokes flows
Complex geometries
Particle methods
Non-homogen flows
Transport
Biological flows
Mucus flows
Mucus flows 1 Context and motivation
Language English
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References Damy T., Burgel P.-R., Pepin J.-L., Boelle P.-Y., Cracowski C., Murris-Espin M., et al. Pulmonary acceleration time to optimize the timing of lung transplant in cystic fibrosis.
Monaghan J. J. Extrapolating B-Splines for interpolation.
2012
Cottet G.-H., Poncet P. Advances in direct numerical simulations of three-dimensional wall-bounded flows by Particle in Cell methods.
El Ossmani M., Poncet P. Efficiency of multi-scale hybrid grid-particle vortex methods. SIAM MMS 2010;. 8(5):;1; 1671-1690.
2006
113-146.
2003
(2): 253-262.
Series Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems, Springer, New York; 2012.
(4): B925-B949.
136-158.
Bergdorf M., Koumoutsakos P. A lagrangian particle-wavelet method.
1988;.
Chatelin R., Poncet P. A hybrid grid-particle method for moving bodies in a 3D Stokes flow with variable viscosity
980-995.
(1): 75-83.
761-766.
1985
Chatelin R., Poncet P. Particle methods for 3D biological flows with variable density and viscosity.
2013
2012.
Sweet R. A Parallel and Vector Variant of the Cyclic Reduction Algorithm.
Adams J., MUDPACK: Multigrid Fortran Software for the Efficient Solution of Linear Elliptic Partial Differen- tial Equations
1989
Thiriet M.
10.1016/j.piutam.2015.11.012_bib0035
10.1016/j.piutam.2015.11.012_bib0045
10.1016/j.piutam.2015.11.012_bib0010
10.1016/j.piutam.2015.11.012_bib0005
10.1016/j.piutam.2015.11.012_bib0015
10.1016/j.piutam.2015.11.012_bib0025
10.1016/j.piutam.2015.11.012_bib0020
10.1016/j.piutam.2015.11.012_bib0030
10.1016/j.piutam.2015.11.012_bib0040
10.1016/j.piutam.2015.11.012_bib0050
References_xml – reference: : 113-146.
– reference: 1985
– reference: El Ossmani M., Poncet P. Efficiency of multi-scale hybrid grid-particle vortex methods. SIAM MMS 2010;. 8(5):;1; 1671-1690.
– reference: : 761-766.
– reference: Damy T., Burgel P.-R., Pepin J.-L., Boelle P.-Y., Cracowski C., Murris-Espin M., et al. Pulmonary acceleration time to optimize the timing of lung transplant in cystic fibrosis.
– reference: (2): 253-262.
– reference: 1988;.
– reference: 2013;
– reference: Cottet G.-H., Poncet P. Advances in direct numerical simulations of three-dimensional wall-bounded flows by Particle in Cell methods.
– reference: : 980-995.
– reference: . Series Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems, Springer, New York; 2012.
– reference: Adams J., MUDPACK: Multigrid Fortran Software for the Efficient Solution of Linear Elliptic Partial Differen- tial Equations,
– reference: ; 2012.
– reference: Monaghan J. J. Extrapolating B-Splines for interpolation.
– reference: Bergdorf M., Koumoutsakos P. A lagrangian particle-wavelet method.
– reference: (1): 75-83.
– reference: 2006;
– reference: (4): B925-B949.
– reference: Thiriet M.
– reference: 2012;
– reference: 2003;
– reference: Chatelin R., Poncet P. Particle methods for 3D biological flows with variable density and viscosity.
– reference: : 136-158.
– reference: Sweet R. A Parallel and Vector Variant of the Cyclic Reduction Algorithm.
– reference: 1989;
– reference: Chatelin R., Poncet P. A hybrid grid-particle method for moving bodies in a 3D Stokes flow with variable viscosity
– ident: 10.1016/j.piutam.2015.11.012_bib0040
  doi: 10.1137/090765006
– ident: 10.1016/j.piutam.2015.11.012_bib0035
  doi: 10.1016/0021-9991(85)90006-3
– ident: 10.1016/j.piutam.2015.11.012_bib0050
  doi: 10.1007/978-1-4614-5966-8
– ident: 10.1016/j.piutam.2015.11.012_bib0030
  doi: 10.4103/2045-8932.94838
– ident: 10.1016/j.piutam.2015.11.012_bib0045
  doi: 10.1137/0909050
– ident: 10.1016/j.piutam.2015.11.012_bib0005
  doi: 10.1016/0096-3003(89)90010-6
– ident: 10.1016/j.piutam.2015.11.012_bib0015
  doi: 10.1137/120892921
– ident: 10.1016/j.piutam.2015.11.012_bib0020
– ident: 10.1016/j.piutam.2015.11.012_bib0025
  doi: 10.1016/j.jcp.2003.08.025
– ident: 10.1016/j.piutam.2015.11.012_bib0010
  doi: 10.1137/060652877
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Snippet This proceeding is introducing a fractional step algorithm for diffusion-transport allowing computation of flows with sharp varia- tions of viscosity. This...
This work is introducing a fractional step algorithm for diffusion-transport allowing computation of flows with sharp variations of viscosity. This splitting...
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SubjectTerms 3D Stokes flows
Biological flows
Complex geometries
Computer Science
Human health and pathology
Life Sciences
Mathematics
Modeling and Simulation
Mucus flows
Non-homogen flows
Numerical Analysis
Particle methods
Pulmonology and respiratory tract
Transport
Title Mucus and Ciliated Cells of Human Lung: Splitting Strategies for Particle Methods and 3D Stokes Flows
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