Mucus and Ciliated Cells of Human Lung: Splitting Strategies for Particle Methods and 3D Stokes Flows

This proceeding is introducing a fractional step algorithm for diffusion-transport allowing computation of flows with sharp varia- tions of viscosity. This splitting also allows to perform transport with Lagrangian methods and diffusion with Eulerian methods, using hybrid grid-particle formulation....

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Veröffentlicht in:Procedia IUTAM Jg. 18; S. 114 - 122
Hauptverfasser: Chatelin, R., Poncet, P., Didier, A., Murris-Espin, M., Anne-Archard, D., Thiriet, M.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Elsevier B.V 2015
Elsevier
Schlagworte:
3D Stokes flows
Biological flows
Complex geometries
Computer Science
Human health and pathology
Life Sciences
Mathematics
Modeling and Simulation
Mucus flows
Non-homogen flows
Numerical Analysis
Particle methods
Pulmonology and respiratory tract
Transport
3D Stokes flows
Complex geometries
Particle methods
Non-homogen flows
Transport
Biological flows
Mucus flows
Mucus flows 1 Context and motivation
ISSN:2210-9838, 2210-9838
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Zusammenfassung:This proceeding is introducing a fractional step algorithm for diffusion-transport allowing computation of flows with sharp varia- tions of viscosity. This splitting also allows to perform transport with Lagrangian methods and diffusion with Eulerian methods, using hybrid grid-particle formulation. This splitting algorithm is globally second order. It is applied to computation of mucus mo- bility in human lungs, where epithelium ciliated cells are beating. A sufficient mobility is required to have healthy configurations. Our goal is to study the dependency of mucus mobility with respect to its viscosity in order to investigate mechanisms involved in pathologies such as cystic fibrosis.
ISSN:2210-9838
2210-9838
DOI:10.1016/j.piutam.2015.11.012