Treatment Outcomes in Multidrug-Resistant Tuberculosis

Multidrug-resistant tuberculosis is a major global challenge. This report examines the definition of treatment success and its effect on determining cure. To the Editor: Despite lengthy treatment with costly second-line drug regimens, curing multidrug-resistant (MDR) tuberculosis (bacillary resistan...

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Published in:The New England journal of medicine Vol. 375; no. 11; pp. 1103 - 1105
Main Authors: Günther, Gunar, Lange, Christoph, Alexandru, Sofia, Altet, Neus, Avsar, Korkut, Bang, Didi, Barbuta, Raisa, Bothamley, Graham, Ciobanu, Ana, Crudu, Valeriu, Danilovits, Manfred, Dedicoat, Martin, Duarte, Raquel, Gualano, Gina, Kunst, Heinke, de Lange, Wiel, Leimane, Vaira, Magis-Escurra, Cecile, McLaughlin, Anne-Marie, Muylle, Inge, Polcová, Veronika, Popa, Christina, Rumetshofer, Rudolf, Skrahina, Alena, Solodovnikova, Varvara, Spinu, Victor, Tiberi, Simon, Viiklepp, Piret, van Leth, Frank
Format: Journal Article
Language:English
Published: United States Massachusetts Medical Society 15.09.2016
Subjects:
Clinical outcomes
Humans
Multidrug resistance
Mycobacterium tuberculosis - isolation & purification
Outcome Assessment (Health Care) - methods
Treatment Outcome
Tuberculosis
Tuberculosis, Multidrug-Resistant - drug therapy
World Health Organization
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Summary:Multidrug-resistant tuberculosis is a major global challenge. This report examines the definition of treatment success and its effect on determining cure. To the Editor: Despite lengthy treatment with costly second-line drug regimens, curing multidrug-resistant (MDR) tuberculosis (bacillary resistance to at least isoniazid and rifampin) remains a challenge. 1 The World Health Organization (WHO) defines “cure” as “treatment completion” with at least three negative cultures after the intensive phase of therapy in the absence of “treatment failure.” The definition of “treatment failure” requires early termination of treatment or the need for permanent regimen change of at least two antituberculosis drugs. “Treatment success” is defined as the sum of cure and treatment completion. 2 We evaluated treatment outcomes according to WHO definitions in the TBNET . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMc1603274