Treatment Outcomes in Multidrug-Resistant Tuberculosis

Multidrug-resistant tuberculosis is a major global challenge. This report examines the definition of treatment success and its effect on determining cure. To the Editor: Despite lengthy treatment with costly second-line drug regimens, curing multidrug-resistant (MDR) tuberculosis (bacillary resistan...

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Published in:The New England journal of medicine Vol. 375; no. 11; pp. 1103 - 1105
Main Authors: Günther, Gunar, Lange, Christoph, Alexandru, Sofia, Altet, Neus, Avsar, Korkut, Bang, Didi, Barbuta, Raisa, Bothamley, Graham, Ciobanu, Ana, Crudu, Valeriu, Danilovits, Manfred, Dedicoat, Martin, Duarte, Raquel, Gualano, Gina, Kunst, Heinke, de Lange, Wiel, Leimane, Vaira, Magis-Escurra, Cecile, McLaughlin, Anne-Marie, Muylle, Inge, Polcová, Veronika, Popa, Christina, Rumetshofer, Rudolf, Skrahina, Alena, Solodovnikova, Varvara, Spinu, Victor, Tiberi, Simon, Viiklepp, Piret, van Leth, Frank
Format: Journal Article
Language:English
Published: United States Massachusetts Medical Society 15.09.2016
Subjects:
Clinical outcomes
Humans
Multidrug resistance
Mycobacterium tuberculosis - isolation & purification
Outcome Assessment (Health Care) - methods
Treatment Outcome
Tuberculosis
Tuberculosis, Multidrug-Resistant - drug therapy
World Health Organization
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Abstract Multidrug-resistant tuberculosis is a major global challenge. This report examines the definition of treatment success and its effect on determining cure. To the Editor: Despite lengthy treatment with costly second-line drug regimens, curing multidrug-resistant (MDR) tuberculosis (bacillary resistance to at least isoniazid and rifampin) remains a challenge. 1 The World Health Organization (WHO) defines “cure” as “treatment completion” with at least three negative cultures after the intensive phase of therapy in the absence of “treatment failure.” The definition of “treatment failure” requires early termination of treatment or the need for permanent regimen change of at least two antituberculosis drugs. “Treatment success” is defined as the sum of cure and treatment completion. 2 We evaluated treatment outcomes according to WHO definitions in the TBNET . . .
AbstractList Multidrug-resistant tuberculosis is a major global challenge. This report examines the definition of treatment success and its effect on determining cure.
Multidrug-resistant tuberculosis is a major global challenge. This report examines the definition of treatment success and its effect on determining cure. To the Editor: Despite lengthy treatment with costly second-line drug regimens, curing multidrug-resistant (MDR) tuberculosis (bacillary resistance to at least isoniazid and rifampin) remains a challenge. 1 The World Health Organization (WHO) defines “cure” as “treatment completion” with at least three negative cultures after the intensive phase of therapy in the absence of “treatment failure.” The definition of “treatment failure” requires early termination of treatment or the need for permanent regimen change of at least two antituberculosis drugs. “Treatment success” is defined as the sum of cure and treatment completion. 2 We evaluated treatment outcomes according to WHO definitions in the TBNET . . .
Author McLaughlin, Anne-Marie
Avsar, Korkut
Rumetshofer, Rudolf
Polcová, Veronika
Ciobanu, Ana
Skrahina, Alena
Crudu, Valeriu
Bang, Didi
Duarte, Raquel
Alexandru, Sofia
van Leth, Frank
Magis-Escurra, Cecile
Gualano, Gina
Tiberi, Simon
Lange, Christoph
Altet, Neus
Günther, Gunar
Dedicoat, Martin
de Lange, Wiel
Viiklepp, Piret
Kunst, Heinke
Danilovits, Manfred
Spinu, Victor
Popa, Christina
Leimane, Vaira
Muylle, Inge
Solodovnikova, Varvara
Bothamley, Graham
Barbuta, Raisa
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  organization: Statens Serum Institut, Copenhagen, Denmark
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  organization: Tartu University Lung Hospital, Tartu, Estonia
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  organization: Heart of England Foundation Trust, Birmingham, United Kingdom
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  givenname: Raquel
  surname: Duarte
  fullname: Duarte, Raquel
  organization: Porto University, Porto, Portugal
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  givenname: Gina
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  organization: Lazzaro Spallanzani National Institute for Infectious Diseases, Rome, Italy
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  organization: Queen Mary University Hospital, London, United Kingdom
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  organization: University Medical Center St. Pieter, Brussels, Belgium
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  organization: Amsterdam Institute for Global Health and Development, Amsterdam, the Netherlands
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Cites_doi 10.3201/eid2103.141343
10.5588/ijtld.15.0274
10.1016/S2213-2600(15)00036-3
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References Günther, G, van Leth, F, Altet, N (r004) 2015; 19
Günther, G, van Leth, F, Alexandru, S (r003) 2015; 21
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Kurbatova, EV, Cegielski, JP, Lienhardt, C (r005) 2015; 3
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Snippet Multidrug-resistant tuberculosis is a major global challenge. This report examines the definition of treatment success and its effect on determining cure. To...
Multidrug-resistant tuberculosis is a major global challenge. This report examines the definition of treatment success and its effect on determining cure.
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SubjectTerms Clinical outcomes
Humans
Multidrug resistance
Mycobacterium tuberculosis - isolation & purification
Outcome Assessment (Health Care) - methods
Treatment Outcome
Tuberculosis
Tuberculosis, Multidrug-Resistant - drug therapy
World Health Organization
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Title Treatment Outcomes in Multidrug-Resistant Tuberculosis
URI https://nejm.org/doi/full/10.1056/NEJMc1603274
https://www.ncbi.nlm.nih.gov/pubmed/27626539
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Volume 375
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