5α-Reductase type 1 deficiency or inhibition predisposes to insulin resistance, hepatic steatosis, and liver fibrosis in rodents

5α-Reductase type 1 (5αR1) catalyses A-ring reduction of androgens and glucocorticoids in liver, potentially influencing hepatic manifestations of the metabolic syndrome. Male mice, homozygous for a disrupted 5αR1 allele (5αR1 knockout [KO] mice), were studied after metabolic (high-fat diet) and fib...

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Bibliographic Details
Published in:	Diabetes (New York, N.Y.) Vol. 64; no. 2; p. 447
Main Authors:	Livingstone, Dawn E W, Barat, Pascal, Di Rollo, Emma M, Rees, Georgina A, Weldin, Benjamin A, Rog-Zielinska, Eva A, MacFarlane, David P, Walker, Brian R, Andrew, Ruth
Format:	Journal Article
Language:	English
Published:	United States 01.02.2015
Subjects:	5-alpha Reductase Inhibitors - pharmacology Animals Cholestenone 5 alpha-Reductase - genetics Cholestenone 5 alpha-Reductase - metabolism Dietary Fats - administration & dosage Dietary Fats - adverse effects Enzyme Assays Fatty Liver - etiology Finasteride - pharmacology Insulin Resistance Liver Cirrhosis - metabolism Male Mice Mice, Knockout Rats RNA, Messenger - genetics RNA, Messenger - metabolism Weight Gain
ISSN:	1939-327X, 1939-327X
Online Access:	Get more information
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