Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

Background In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronavirus pneumonia (NCP) cases were a concern. Objectives To describe the coagulation feature of patients with NCP. Methods Conventional coagulation resu...

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Vydáno v:Journal of thrombosis and haemostasis Ročník 18; číslo 4; s. 844 - 847
Hlavní autoři: Tang, Ning, Li, Dengju, Wang, Xiong, Sun, Ziyong
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Elsevier Limited 01.04.2020
John Wiley and Sons Inc
Témata:
Adolescent
Adult
Aged
Aged, 80 and over
Betacoronavirus
Blood Coagulation
Brief Report
China
coagulation parameter
Coronaviridae
Coronavirus Infections - mortality
Coronavirus Infections - physiopathology
Coronaviruses
COVID-19
Disseminated intravascular coagulation
Disseminated Intravascular Coagulation - mortality
Disseminated Intravascular Coagulation - virology
D‐dimer
Female
Fibrin
fibrin degradation product
Fibrin Fibrinogen Degradation Products - analysis
HAEMOSTASIS
Humans
Male
Middle Aged
novel coronavirus pneumonia
Pandemics
Partial Thromboplastin Time
Pneumonia
Pneumonia, Viral - mortality
Pneumonia, Viral - physiopathology
Prothrombin
Prothrombin Time
Retrospective Studies
SARS-CoV-2
Thromboplastin
Young Adult
China
D-dimer
novel coronavirus pneumonia
fibrin degradation product
coagulation parameter
disseminated intravascular coagulation
ISSN:1538-7933, 1538-7836, 1538-7836
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Shrnutí:Background In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronavirus pneumonia (NCP) cases were a concern. Objectives To describe the coagulation feature of patients with NCP. Methods Conventional coagulation results and outcomes of 183 consecutive patients with confirmed NCP in Tongji hospital were retrospectively analyzed. Results The overall mortality was 11.5%, the non‐survivors revealed significantly higher D‐dimer and fibrin degradation product (FDP) levels, longer prothrombin time and activated partial thromboplastin time compared to survivors on admission (P < .05); 71.4% of non‐survivors and 0.6% survivors met the criteria of disseminated intravascular coagulation during their hospital stay. Conclusions The present study shows that abnormal coagulation results, especially markedly elevated D‐dimer and FDP are common in deaths with NCP.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Final decision: David Lillicrap, 18 February 2020
Manuscript handled by: David Lillicrap
ISSN:1538-7933
1538-7836
1538-7836
DOI:10.1111/jth.14768