PET Quantification in Healthy Humans of Cyclooxygenase-2, a Potential Biomarker of Neuroinflammation

Cyclooxygenase-2 (COX-2) is present in a healthy brain at low densities but can be markedly upregulated by excitatory input and by inflammogens. This study evaluated the sensitivity of the PET radioligand [ C]-6-methoxy-2-(4-(methylsulfonyl)phenyl)- -(thiophen-2-ylmethyl)pyrimidin-4-amine ([ C]MC1)...

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Bibliographic Details
Published in:	The Journal of nuclear medicine (1978) Vol. 66; no. 3; p. 398
Main Authors:	Yan, Xuefeng, Noergaard, Martin, Morse, Cheryl L, Liow, Jeih-San, Hong, Jinsoo, Greve, Douglas, Telu, Sanjay, Kim, Min-Jeong, Montero Santamaria, Jose A, Galassi, Anthony, Feng, Ningping, Williams Avram, Sarah K, Usdin, Ted B, Wu, Shawn, Zhang, Andrea, Manly, Lester S, Jenkins, Madeline, Van Buskirk, Maia, Lee, Adrian, Zoghbi, Sami S, Pike, Victor W, Zanotti-Fregonara, Paolo, Innis, Robert B
Format:	Journal Article
Language:	English
Published:	United States 01.03.2025
Subjects:	Adult Animals Biomarkers - metabolism Brain - diagnostic imaging Brain - metabolism Celecoxib Cyclooxygenase 2 - metabolism Female Healthy Volunteers Humans Male Mice Mice, Transgenic Middle Aged Neuroinflammatory Diseases - diagnostic imaging Neuroinflammatory Diseases - enzymology Neuroinflammatory Diseases - metabolism Positron-Emission Tomography - methods Rats Young Adult human brain COX-2 neuroinflammation PET
ISSN:	1535-5667, 1535-5667
Online Access:	Get more information
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