Gold nanocages as contrast agents for spectroscopic optical coherence tomography

We describe gold nanocages as a new class of potential contrast agent for spectroscopic optical coherence tomography (OCT). Monodispersed gold nanocages of an approximately 35 nm edge length exhibit strong optical resonance, with the peak wavelength tunable in the near-infrared range. We characteriz...

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Veröffentlicht in:Optics letters Jg. 30; H. 22; S. 3048
Hauptverfasser: Cang, Hu, Sun, Tao, Li, Zhi-Yuan, Chen, Jingyi, Wiley, Benjamin J, Xia, Younan, Li, Xingde
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 15.11.2005
Schlagworte:
Contrast Media
Image Enhancement - methods
Nanostructures - chemistry
Nanostructures - ultrastructure
Particle Size
Reproducibility of Results
Sensitivity and Specificity
Tomography, Optical Coherence - methods
ISSN:0146-9592
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Zusammenfassung:We describe gold nanocages as a new class of potential contrast agent for spectroscopic optical coherence tomography (OCT). Monodispersed gold nanocages of an approximately 35 nm edge length exhibit strong optical resonance, with the peak wavelength tunable in the near-infrared range. We characterized the optical properties of the nanocage by using OCT experiments along with numerical calculations, revealing an absorption cross section approximately 5 orders of magnitude larger than conventional dyes. Experiments with tissue phantoms demonstrated that the nanocages provide enhanced contrast for spectroscopic as well as conventional intensity-based OCT imaging.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0146-9592
DOI:10.1364/ol.30.003048