Cross-talk between non-coding RNAs and PI3K/AKT/mTOR pathway in colorectal cancer

Colorectal cancer (CRC) is the third commonest cancer globally, with metastasis being the reason for cancer-associated mortality. Much is still unknown biochemically about CRC, and with current treatments that are not wholly effective over time, new therapeutics are urgently needed. Emerging evidenc...

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Veröffentlicht in:Molecular biology reports Jg. 48; H. 5; S. 4797 - 4811
Hauptverfasser: Moafian, Zeinab, Maghrouni, Abolfazl, Soltani, Arash, Hashemy, Seyed Isaac
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Dordrecht Springer Netherlands 01.05.2021
Springer Nature B.V
Schlagworte:
1-Phosphatidylinositol 3-kinase
AKT protein
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Cancer
Colorectal cancer
Colorectal carcinoma
colorectal neoplasms
Histology
Life Sciences
Metastases
metastasis
microRNA
molecular biology
Morphology
mortality
Non-coding RNA
Review
Therapeutic targets
therapeutics
TOR protein
mTOR pathway
AKT
PI3K
Colorectal cancer (CRC)
MicroRNAs
LncRNAs
ISSN:0301-4851, 1573-4978, 1573-4978
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Abstract Colorectal cancer (CRC) is the third commonest cancer globally, with metastasis being the reason for cancer-associated mortality. Much is still unknown biochemically about CRC, and with current treatments that are not wholly effective over time, new therapeutics are urgently needed. Emerging evidence has shown the importance of non-coding RNAs such as lncRNAs and miRNAs functions in the development and progression of CRC. However, the exact underlying mechanism of these types of RNAs in CRC is still mostly unknown. PI3K/AKT/mTOR pathway contributes to many cellular processes, and dysregulation of this pathway frequently occurs in cancers. In this review, the authors have mostly focused on the significant non-coding RNAs regulators of the PI3K/AKT/mTOR pathway and their contribution to the development or inhibition of CRC and their potential as diagnostic or therapeutic targets in CRC treatment.
AbstractList Colorectal cancer (CRC) is the third commonest cancer globally, with metastasis being the reason for cancer-associated mortality. Much is still unknown biochemically about CRC, and with current treatments that are not wholly effective over time, new therapeutics are urgently needed. Emerging evidence has shown the importance of non-coding RNAs such as lncRNAs and miRNAs functions in the development and progression of CRC. However, the exact underlying mechanism of these types of RNAs in CRC is still mostly unknown. PI3K/AKT/mTOR pathway contributes to many cellular processes, and dysregulation of this pathway frequently occurs in cancers. In this review, the authors have mostly focused on the significant non-coding RNAs regulators of the PI3K/AKT/mTOR pathway and their contribution to the development or inhibition of CRC and their potential as diagnostic or therapeutic targets in CRC treatment.
Colorectal cancer (CRC) is the third commonest cancer globally, with metastasis being the reason for cancer-associated mortality. Much is still unknown biochemically about CRC, and with current treatments that are not wholly effective over time, new therapeutics are urgently needed. Emerging evidence has shown the importance of non-coding RNAs such as lncRNAs and miRNAs functions in the development and progression of CRC. However, the exact underlying mechanism of these types of RNAs in CRC is still mostly unknown. PI3K/AKT/mTOR pathway contributes to many cellular processes, and dysregulation of this pathway frequently occurs in cancers. In this review, the authors have mostly focused on the significant non-coding RNAs regulators of the PI3K/AKT/mTOR pathway and their contribution to the development or inhibition of CRC and their potential as diagnostic or therapeutic targets in CRC treatment.Colorectal cancer (CRC) is the third commonest cancer globally, with metastasis being the reason for cancer-associated mortality. Much is still unknown biochemically about CRC, and with current treatments that are not wholly effective over time, new therapeutics are urgently needed. Emerging evidence has shown the importance of non-coding RNAs such as lncRNAs and miRNAs functions in the development and progression of CRC. However, the exact underlying mechanism of these types of RNAs in CRC is still mostly unknown. PI3K/AKT/mTOR pathway contributes to many cellular processes, and dysregulation of this pathway frequently occurs in cancers. In this review, the authors have mostly focused on the significant non-coding RNAs regulators of the PI3K/AKT/mTOR pathway and their contribution to the development or inhibition of CRC and their potential as diagnostic or therapeutic targets in CRC treatment.
Author Hashemy, Seyed Isaac
Maghrouni, Abolfazl
Soltani, Arash
Moafian, Zeinab
Author_xml – sequence: 1
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  surname: Moafian
  fullname: Moafian, Zeinab
  organization: Protein Chemistry Laboratory (PCL), Department of Biology, College of Sciences, Shiraz University of Medical Sciences
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  givenname: Abolfazl
  surname: Maghrouni
  fullname: Maghrouni, Abolfazl
  organization: Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences
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  givenname: Arash
  surname: Soltani
  fullname: Soltani, Arash
  organization: Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences
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  givenname: Seyed Isaac
  orcidid: 0000-0002-1323-5250
  surname: Hashemy
  fullname: Hashemy, Seyed Isaac
  email: hashemyi@mums.ac.ir
  organization: Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Surgical Oncology Research Center, Mashhad University of Medical Sciences
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SubjectTerms 1-Phosphatidylinositol 3-kinase
AKT protein
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Cancer
Colorectal cancer
Colorectal carcinoma
colorectal neoplasms
Histology
Life Sciences
Metastases
metastasis
microRNA
molecular biology
Morphology
mortality
Non-coding RNA
Review
Therapeutic targets
therapeutics
TOR protein
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