Osteitis deformans (Paget’s disease) in a Burmese python (Python molurus bivittatus) – A case report

Osteitis deformans (Paget’s disease of bone) is a chronic focal disorder of bone remodelling characterized by an initial increase in osteoclast-mediated bone resorption, with subsequent compensatory increase in new bone formation, resulting in a disorganized mosaic of woven and lamellar bone. In the...

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Bibliographic Details
Published in:The veterinary journal (1997) Vol. 174; no. 3; pp. 669 - 672
Main Authors: Preziosi, Rosario, Diana, Alessia, Florio, Daniela, Gustinelli, Andrea, Nardini, Giordano
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.11.2007
Subjects:
animal diseases
Animals
Boidae
Bone pathology
bone resorption
Burmese python (Python molurus bivittatus)
case studies
histopathology
Male
Osteitis Deformans
Osteitis Deformans - pathology
Osteitis Deformans - veterinary
osteoclasts
Paget’s disease
pathology
Python molurus
radiography
Reptile
snakes
veterinary
Osteitis deformans
Burmese python (Python molurus bivittatus)
Reptile
Bone pathology
Paget’s disease
ISSN:1090-0233, 1532-2971
Online Access:Get full text
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Summary:Osteitis deformans (Paget’s disease of bone) is a chronic focal disorder of bone remodelling characterized by an initial increase in osteoclast-mediated bone resorption, with subsequent compensatory increase in new bone formation, resulting in a disorganized mosaic of woven and lamellar bone. In the Burmese python (Python molurus bivittatus) of this report, multifocal gross swellings involving the proximal third of the vertebral spine were observed and associated with anorexia, a relative inability to move or to fully extend the body, and to strike at prey. Serum biochemistry revealed elevated alkaline-phosphatase activity. Radiographic changes (irregular bone proliferation along the vertebral margins), computed tomography scan results (abnormal mineral density), and histopathological features (generalized thickening of the bony trabeculae at the expense of the intertrabecular spaces and irregular patches of lamellar bone with a characteristic “mosaic” pattern) indicated osteitis deformans.
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ISSN:1090-0233
1532-2971
DOI:10.1016/j.tvjl.2006.11.012