Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics

Initial replication of SARS-CoV-2 in the upper respiratory tract is required to establish infection, and the replication level correlates with the likelihood of viral transmission. Here, we examined the role of host innate immune defenses in restricting early SARS-CoV-2 infection using transcriptomi...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	The Journal of experimental medicine Ročník 218; číslo 8
Hlavní autoři:	Cheemarla, Nagarjuna R, Watkins, Timothy A, Mihaylova, Valia T, Wang, Bao, Zhao, Dejian, Wang, Guilin, Landry, Marie L, Foxman, Ellen F
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 02.08.2021
Témata:	Adult Aged Aged, 80 and over Angiotensin-Converting Enzyme 2 - genetics Case-Control Studies Chemokine CXCL10 - metabolism COVID-19 - immunology COVID-19 - virology Disease Susceptibility - immunology Female Gene Expression Profiling Host-Pathogen Interactions - physiology Humans Immunity, Innate - physiology Interferons - genetics Interferons - immunology Interferons - metabolism Male Middle Aged Nasopharynx - virology Picornaviridae Infections - immunology Picornaviridae Infections - virology SARS-CoV-2 - genetics SARS-CoV-2 - physiology Viral Load Virus Replication
ISSN:	1540-9538, 1540-9538
On-line přístup:	Zjistit podrobnosti o přístupu
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!