The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics

Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases. TNF-α binds to two different receptors, which initiate signal tr...

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Vydáno v:International journal of molecular sciences Ročník 22; číslo 5; s. 2719
Hlavní autoři: Jang, Dan-in, Lee, A-Hyeon, Shin, Hye-Yoon, Song, Hyo-Ryeong, Park, Jong-Hwi, Kang, Tae-Bong, Lee, Sang-Ryong, Yang, Seung-Hoon
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI 08.03.2021
Témata:
Animals
Autoimmune Diseases - drug therapy
Autoimmune Diseases - immunology
Autoimmune Diseases - pathology
Chronic Disease
Humans
Immunologic Factors - therapeutic use
Review
Signal Transduction - drug effects
Signal Transduction - immunology
Tumor Necrosis Factor-alpha - antagonists & inhibitors
Tumor Necrosis Factor-alpha - immunology
autoimmune diseases
psoriatic arthritis
TNF-α
rheumatoid arthritis
inflammatory bowel disease
TNF-α inhibitors
ISSN:1422-0067, 1422-0067
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Shrnutí:Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases. TNF-α binds to two different receptors, which initiate signal transduction pathways. These pathways lead to various cellular responses, including cell survival, differentiation, and proliferation. However, the inappropriate or excessive activation of TNF-α signaling is associated with chronic inflammation and can eventually lead to the development of pathological complications such as autoimmune diseases. Understanding of the TNF-α signaling mechanism has been expanded and applied for the treatment of immune diseases, which has resulted in the development of effective therapeutic tools, including TNF-α inhibitors. Currently, clinically approved TNF-α inhibitors have shown noticeable potency in a variety of autoimmune diseases, and novel TNF-α signaling inhibitors are being clinically evaluated. In this review, we briefly introduce the impact of TNF-α signaling on autoimmune diseases and its inhibitors, which are used as therapeutic agents against autoimmune diseases.
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These authors contributed equally to this work.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms22052719