The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics

Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases. TNF-α binds to two different receptors, which initiate signal tr...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 22; no. 5; p. 2719
Main Authors:	Jang, Dan-in, Lee, A-Hyeon, Shin, Hye-Yoon, Song, Hyo-Ryeong, Park, Jong-Hwi, Kang, Tae-Bong, Lee, Sang-Ryong, Yang, Seung-Hoon
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI 08.03.2021
Subjects:	Animals Autoimmune Diseases - drug therapy Autoimmune Diseases - immunology Autoimmune Diseases - pathology Chronic Disease Humans Immunologic Factors - therapeutic use Review Signal Transduction - drug effects Signal Transduction - immunology Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - immunology autoimmune diseases psoriatic arthritis TNF-α rheumatoid arthritis inflammatory bowel disease TNF-α inhibitors
ISSN:	1422-0067, 1422-0067
Online Access:	Get full text
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