Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions

Transcription factors ThPOK and Runx3 regulate the differentiation of "helper" CD4+ and "cytotoxic" CD8+ T cell lineages respectively, inducing single positive (SP) T cells that enter the periphery with the expression of either the CD4 or CD8 co-receptor. Despite the expectation...

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Vydané v:	The Journal of experimental medicine Ročník 219; číslo 6
Hlavní autori:	Schad, Sara E, Chow, Andrew, Mangarin, Levi, Pan, Heng, Zhang, Jiajia, Ceglia, Nicholas, Caushi, Justina X, Malandro, Nicole, Zappasodi, Roberta, Gigoux, Mathieu, Hirschhorn, Daniel, Budhu, Sadna, Amisaki, Masataka, Arniella, Monica, Redmond, David, Chaft, Jamie, Forde, Patrick M, Gainor, Justin F, Hellmann, Matthew D, Balachandran, Vinod, Shah, Sohrab, Smith, Kellie N, Pardoll, Drew, Elemento, Olivier, Wolchok, Jedd D, Merghoub, Taha
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 06.06.2022
Predmet:	Animals CD4 Antigens - metabolism CD4-Positive T-Lymphocytes CD8 Antigens - metabolism CD8-Positive T-Lymphocytes Cell Differentiation Cell Lineage - genetics Melanoma - metabolism Mice T-Lymphocyte Subsets
ISSN:	1540-9538, 1540-9538
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