Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions

Transcription factors ThPOK and Runx3 regulate the differentiation of "helper" CD4+ and "cytotoxic" CD8+ T cell lineages respectively, inducing single positive (SP) T cells that enter the periphery with the expression of either the CD4 or CD8 co-receptor. Despite the expectation...

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Bibliographic Details

Published in:	The Journal of experimental medicine Vol. 219; no. 6
Main Authors:	Schad, Sara E, Chow, Andrew, Mangarin, Levi, Pan, Heng, Zhang, Jiajia, Ceglia, Nicholas, Caushi, Justina X, Malandro, Nicole, Zappasodi, Roberta, Gigoux, Mathieu, Hirschhorn, Daniel, Budhu, Sadna, Amisaki, Masataka, Arniella, Monica, Redmond, David, Chaft, Jamie, Forde, Patrick M, Gainor, Justin F, Hellmann, Matthew D, Balachandran, Vinod, Shah, Sohrab, Smith, Kellie N, Pardoll, Drew, Elemento, Olivier, Wolchok, Jedd D, Merghoub, Taha
Format:	Journal Article
Language:	English
Published:	United States 06.06.2022
Subjects:	Animals CD4 Antigens - metabolism CD4-Positive T-Lymphocytes CD8 Antigens - metabolism CD8-Positive T-Lymphocytes Cell Differentiation Cell Lineage - genetics Melanoma - metabolism Mice T-Lymphocyte Subsets
ISSN:	1540-9538, 1540-9538
Online Access:	Get more information
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