Volume Rendering of Dense B-Scan Optical Coherence Tomography Angiography to Evaluate the Connectivity of Macular Blood Flow

To characterize macular blood flow connectivity using volume rendering of dense B-scan (DB) optical coherence tomography angiography (OCTA) data. This was a prospective, cross-sectional, observational study. DB OCTA perifoveal scans were performed on healthy subjects using the Spectralis HRA+OCT2. A...

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Vydáno v:Investigative ophthalmology & visual science Ročník 61; číslo 6; s. 44
Hlavní autoři: Cabral, Diogo, Pereira, Telmo, Ledesma-Gil, Gerardo, Rodrigues, Catarina, Coscas, Florence, Sarraf, David, Freund, K. Bailey
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States The Association for Research in Vision and Ophthalmology 19.06.2020
Témata:
Adult
Cross-Sectional Studies
Female
Fluorescein Angiography - methods
Follow-Up Studies
Fundus Oculi
Humans
Macula Lutea - blood supply
Macula Lutea - diagnostic imaging
Male
Prospective Studies
Regional Blood Flow - physiology
Reproducibility of Results
Retina
Retinal Vessels - diagnostic imaging
Retinal Vessels - physiology
Tomography, Optical Coherence - methods
ISSN:1552-5783, 0146-0404, 1552-5783
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Popis
Shrnutí:To characterize macular blood flow connectivity using volume rendering of dense B-scan (DB) optical coherence tomography angiography (OCTA) data. This was a prospective, cross-sectional, observational study. DB OCTA perifoveal scans were performed on healthy subjects using the Spectralis HRA+OCT2. A volumetric projection artifact removal algorithm and customized filters were applied to raw OCTA voxel data. Volume rendering was performed using a workflow on Imaris 9.5 software. Vascular graphs were obtained from angiographic data using the algorithm threshold-loops. Superficial arteries and veins were identified from color fundus photographs and connections between adjacent arteries and veins displayed using the shortest path algorithm. Connective pathway locations were analyzed with cross-sectional OCT and OCTA to determine their course through the superficial vascular complex (SVC) and the deep vascular complex (DVC). Fourteen eyes from seven subjects (mean age: 28 ± 5 years; 3 women) were included in this analysis. One hundred and twenty-six vascular connections were analyzed. In all cases, the shortest path connections between superficial arteries and veins coursed through the DVC. We did not identify shortest path connections confined to the SVC. Volumetric analysis of vascular connectivity supports a predominantly in-series arrangement of blood flow between the SVC and DVC within the human perifoveal macula.
Bibliografie:ObjectType-Article-1
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ISSN:1552-5783
0146-0404
1552-5783
DOI:10.1167/iovs.61.6.44