CCR8 expression identifies CD4 memory T cells enriched for FOXP3+ regulatory and Th2 effector lymphocytes

CD4+ Th2 cells are important regulators of allergic inflammation. CCR8 is thought to play a role in Th2-mediated responses, however, expression of CCR8 in peripheral blood has not been fully characterized. Using a fluorescent form of the ligand selective for CCR8 (F-CCL1), we identified the leukocyt...

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Veröffentlicht in:	The Journal of immunology (1950) Jg. 177; H. 10; S. 6940
Hauptverfasser:	Soler, Dulce, Chapman, Tobias R, Poisson, Louis R, Wang, Lin, Cote-Sierra, Javier, Ryan, Mark, McDonald, Alice, Badola, Sunita, Fedyk, Eric, Coyle, Anthony J, Hodge, Martin R, Kolbeck, Roland
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.11.2006
Schlagworte:	Animals CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Chemokine CCL1 Chemokines, CC - physiology Chemotaxis, Leukocyte - genetics Chemotaxis, Leukocyte - immunology Forkhead Transcription Factors - biosynthesis Humans Immunologic Memory - genetics Immunophenotyping Lymphocyte Activation - genetics Lymphocyte Activation - immunology Macaca fascicularis Mice Mice, Inbred C57BL Mice, Knockout Receptors, CCR8 Receptors, Chemokine - biosynthesis Receptors, Chemokine - blood Receptors, Chemokine - deficiency Receptors, Chemokine - physiology T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Th2 Cells - cytology Th2 Cells - immunology Th2 Cells - metabolism
ISSN:	0022-1767
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