Emergency department admission and hospitalization for COPD exacerbation and particulate matter short-term exposure in Brescia, a highly polluted town in northern Italy

Short-term exposure to high Particulate Matter (PM) concentrations worsens several respiratory conditions. We evaluated the relationship between short-term exposure to Particulate Matter and fine Particulate Matter (PM10 - PM2.5) and Emergency Department (ED) admissions and hospitalizations for COPD...

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Vydané v:Respiratory medicine Ročník 179; s. 106334
Hlavní autori: Pini, Laura, Giordani, Jordan, Gardini, Giulia, Concoreggi, Carlo, Pini, Alessandro, Perger, Elisa, Vizzardi, Enrico, Di Bona, Danilo, Cappelli, Carlo, Ciarfaglia, Manuela, Tantucci, Claudio
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England 01.04.2021
ISSN:1532-3064, 1532-3064
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Shrnutí:Short-term exposure to high Particulate Matter (PM) concentrations worsens several respiratory conditions. We evaluated the relationship between short-term exposure to Particulate Matter and fine Particulate Matter (PM10 - PM2.5) and Emergency Department (ED) admissions and hospitalizations for COPD exacerbation observed at the University Hospital, Spedali Civili of Brescia, a city with some of the highest yearly levels of air pollution in Italy. We collected data from patients admitted to the ED with a COPD exacerbation diagnosis, starting from January 2014 to January 2016. Daily PM levels were collected from the Environmental Protection Regional Agency (ARPA). We performed a time-series analysis using the Poisson regression model with single and multiple day-lag. Results were expressed as Relative Risk (RR) and Excess of Relative Risk (ER) for COPD exacerbation-related ED admissions and hospitalizations, over a 10μg/m3 increase in PM concentration. We collected data from 431 COPD patients. Both PM10 and PM2.5 were significantly associated with the risk of COPD exacerbation-related ED admission and hospitalization. Each increase of 10μg/m3 of PM10 and PM2.5 corresponded respectively to a RR for ED admissions of 1.06 and 1.08 at lag0-1; 1.06 and 1.09 at lag0-5 (p < 0.05). Similar results for COPD Exacerbation-related hospitalizations were found, with a RR of 1.07 and 1.10 at lag0-1 and 1.07 and 1.11 at lag0-5 for each increase of 10μg/m3 PM10 and PM2.5, respectively. Our findings show that in a highly polluted city of Northern Italy, short-term increase in exposure to PM10-PM2.5 is associated with a higher risk of ED admission and hospitalization due to COPD exacerbation with a greater incidence during the winter season.
Bibliografia:ObjectType-Article-1
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ISSN:1532-3064
1532-3064
DOI:10.1016/j.rmed.2021.106334