RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance

We report that programmed death ligand 2 (PD-L2), a known ligand of PD-1, also binds to repulsive guidance molecule b (RGMb), which was originally identified in the nervous system as a co-receptor for bone morphogenetic proteins (BMPs). PD-L2 and BMP-2/4 bind to distinct sites on RGMb. Normal restin...

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Veröffentlicht in:	The Journal of experimental medicine Jg. 211; H. 5; S. 943
Hauptverfasser:	Xiao, Yanping, Yu, Sanhong, Zhu, Baogong, Bedoret, Denis, Bu, Xia, Francisco, Loise M, Hua, Ping, Duke-Cohan, Jonathan S, Umetsu, Dale T, Sharpe, Arlene H, DeKruyff, Rosemarie H, Freeman, Gordon J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 05.05.2014
Schlagworte:	Animals Bone Morphogenetic Protein 2 - metabolism Cell Line, Tumor Epithelial Cells - metabolism Humans Immune Tolerance - immunology Lung - immunology Lung - metabolism Macrophages, Alveolar - metabolism Mice Nerve Tissue Proteins - immunology Nerve Tissue Proteins - metabolism Programmed Cell Death 1 Ligand 2 Protein - immunology Programmed Cell Death 1 Ligand 2 Protein - metabolism Protein Binding
ISSN:	1540-9538, 1540-9538
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