Ultrasensitive Clostridioides difficile Toxin Testing for Higher Diagnostic Accuracy

Currently available diagnostic tests for infection (CDI) lack specificity or sensitivity, which has led to guideline recommendations for multistep testing algorithms. Ultrasensitive assays for detection of toxins provide measurements of disease-specific markers at very low concentrations. These assa...

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Bibliographic Details
Published in:Journal of clinical microbiology Vol. 58; no. 6
Main Authors: Sandlund, Johanna, Davies, Kerrie, Wilcox, Mark H
Format: Journal Article
Language:English
Published: United States 26.05.2020
Subjects:
ultrasensitive
Clostridioides difficile
toxin
diarrhea
Clostridium difficile
ISSN:1098-660X, 1098-660X
Online Access:Get more information
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Description
Summary:Currently available diagnostic tests for infection (CDI) lack specificity or sensitivity, which has led to guideline recommendations for multistep testing algorithms. Ultrasensitive assays for detection of toxins provide measurements of disease-specific markers at very low concentrations. These assays may show improved accuracy compared to that of current testing methods and offer a potential standalone solution for CDI diagnosis, although large studies of clinical performance and accuracy are lacking.
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ISSN:1098-660X
1098-660X
DOI:10.1128/JCM.01913-19