Characterization of Genomic Variants Associated with Resistance to Bedaquiline and Delamanid in Naive Mycobacterium tuberculosis Clinical Strains

The role of mutations in genes associated with phenotypic resistance to bedaquiline (BDQ) and delamanid (DLM) in complex (MTBc) strains is poorly characterized. A clear understanding of the genetic variants' role is crucial to guide the development of molecular-based drug susceptibility testing...

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Vydané v:	Journal of clinical microbiology Ročník 58; číslo 11
Hlavní autori:	Battaglia, S, Spitaleri, A, Cabibbe, A M, Meehan, C J, Utpatel, C, Ismail, N, Tahseen, S, Skrahina, A, Alikhanova, N, Mostofa Kamal, S M, Barbova, A, Niemann, S, Groenheit, R, Dean, A S, Zignol, M, Rigouts, L, Cirillo, D M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 21.10.2020
Predmet:	Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Diarylquinolines - pharmacology Genomics Humans Microbial Sensitivity Tests Mycobacterium tuberculosis - genetics Nitroimidazoles Oxazoles Tuberculosis, Multidrug-Resistant - drug therapy delamanid resistance to new drugs Mycobacterium tuberculosis bedaquiline whole-genome sequencing
ISSN:	1098-660X, 1098-660X
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