Evolution of the HIV-1 Rev Response Element during Natural Infection Reveals Nucleotide Changes That Correlate with Altered Structure and Increased Activity over Time

The HIV-1 Rev response element (RRE) is a -acting RNA element characterized by multiple stem-loops. Binding and multimerization of the HIV Rev protein on the RRE promote the nucleocytoplasmic export of incompletely spliced mRNAs, an essential step in HIV replication. Most of our understanding of the...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Journal of virology Ročník 93; číslo 11
Hlavní autori:	Sherpa, Chringma, Jackson, Patrick E H, Gray, Laurie R, Anastos, Kathryn, Le Grice, Stuart F J, Hammarskjold, Marie-Louise, Rekosh, David
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.06.2019
Predmet:	Gene Products, rev - genetics Genes, env - genetics Genes, env - physiology HIV Infections - virology HIV Seropositivity - genetics HIV-1 - metabolism HIV-1 - physiology Humans Mutation Nucleic Acid Conformation Nucleotides - metabolism Protein Binding Response Elements - genetics rev Gene Products, Human Immunodeficiency Virus - metabolism rev Gene Products, Human Immunodeficiency Virus - ultrastructure RNA, Messenger - genetics RNA, Viral - genetics Virus Replication - genetics RNA export HIV HIV RRE HIV Rev viral sequence evolution viral sequence variation RNA structure
ISSN:	1098-5514, 1098-5514
On-line prístup:	Zistit podrobnosti o prístupe
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!