Evolution of the HIV-1 Rev Response Element during Natural Infection Reveals Nucleotide Changes That Correlate with Altered Structure and Increased Activity over Time

The HIV-1 Rev response element (RRE) is a -acting RNA element characterized by multiple stem-loops. Binding and multimerization of the HIV Rev protein on the RRE promote the nucleocytoplasmic export of incompletely spliced mRNAs, an essential step in HIV replication. Most of our understanding of the...

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Bibliographic Details
Published in:	Journal of virology Vol. 93; no. 11
Main Authors:	Sherpa, Chringma, Jackson, Patrick E H, Gray, Laurie R, Anastos, Kathryn, Le Grice, Stuart F J, Hammarskjold, Marie-Louise, Rekosh, David
Format:	Journal Article
Language:	English
Published:	United States 01.06.2019
Subjects:	Gene Products, rev - genetics Genes, env - genetics Genes, env - physiology HIV Infections - virology HIV Seropositivity - genetics HIV-1 - metabolism HIV-1 - physiology Humans Mutation Nucleic Acid Conformation Nucleotides - metabolism Protein Binding Response Elements - genetics rev Gene Products, Human Immunodeficiency Virus - metabolism rev Gene Products, Human Immunodeficiency Virus - ultrastructure RNA, Messenger - genetics RNA, Viral - genetics Virus Replication - genetics RNA export HIV HIV RRE HIV Rev viral sequence evolution viral sequence variation RNA structure
ISSN:	1098-5514, 1098-5514
Online Access:	Get more information
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