Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-β and Tau Neuropathology

Here we describe a staged, behavioral testing approach that can be used to screen for compounds that exhibit in vivo efficacy on cognitive and functional motor behaviors in transgenic mouse models of β-amyloidosis and tauopathy. The paradigm includes tests for spontaneous alternation in a Y-maze, no...

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Bibliographic Details
Published in:	Journal of visualized experiments no. 123
Main Authors:	Miedel, Christian J., Patton, Jennifer M., Miedel, Andrew N., Miedel, Edward S., Levenson, Jonathan M.
Format:	Journal Article
Language:	English
Published:	United States MyJove Corporation 28.05.2017
Subjects:	Alzheimer disease animal models Animals cognition Disease Models, Animal Extremities - physiology hippocampus human diseases Humans Medicine memory Mice Mice, Transgenic neuropathology Neuropathology - methods quality control Recognition (Psychology) - physiology Tauopathies - metabolism transgenic animals
ISSN:	1940-087X, 1940-087X
Online Access:	Get full text
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