A Comparison of 4% Succinylated Gelatin Solution versus Normal Saline in Stable Normovolaemic Sheep: Global Haemodynamic, Regional Blood Flow and Oxygen Delivery Effects

The objective of this study was to compare the effects on regional blood flow and regional oxygen delivery of 4% succinylated gelatin solution (Gelofusine®, B. Braun) with those of normal saline. This was a randomised, controlled, crossover large animal study, which took place at the animal laborato...

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Bibliographic Details
Published in:Anaesthesia and intensive care Vol. 35; no. 6; pp. 924 - 931
Main Authors: Wan, L., Bellomo, R., May, C. N.
Format: Journal Article
Language:English
Published: Edgecliff Anaesthesia and Intensive Care 01.12.2007
Sage Publications Ltd. (UK)
Sage Publications Ltd
Subjects:
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Biological and medical sciences
Blood flow
Chemical properties
Dosage and administration
Evaluation
Female
Gelatin
Gelatin - pharmacology
Health aspects
Hemodynamics - drug effects
Injections, Saline
Medical sciences
Oximetry
Oxygen Consumption - drug effects
Physiological aspects
Regional Blood Flow - drug effects
Sheep
Sodium Chloride - pharmacology
Succinates - pharmacology
Australia
Regional blood flow
Oxygen
renal blood flow
Blood flow
mesenteric blood flow
normal saline
Vertebrata
Mammalia
Gelatin
Gelofusine
Anesthesia
Oxygen effect
Sheep
oxygen delivery
Artiodactyla
Cardiac output
Saline solution
Ungulata
Comparative study
ISSN:0310-057X, 1448-0271
Online Access:Get full text
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Summary:The objective of this study was to compare the effects on regional blood flow and regional oxygen delivery of 4% succinylated gelatin solution (Gelofusine®, B. Braun) with those of normal saline. This was a randomised, controlled, crossover large animal study, which took place at the animal laboratory of university physiology institute. The subjects were seven merino cross-ewes. We implanted flow probes around the aorta, coronary, renal and mesenteric arteries. We randomised animals to observation (control), normal saline (one litre over 15 minutes) or Gelofusine * (one litre over 15 minutes). We measured central haemodynamics, organ blood flows, arterial blood gases and haemoglobin every 30 minutes for 210 minutes. Compared to control, both Gelofusine * and normal saline significantly and similarly increased mean arterial pressure, stroke volume, cardiac output and central venous pressure in the first hour (P <0.05). Such changes, however, were transient except for the increase in cardiac output seen with Gelofusine®. Normal saline significantly increased mesenteric blood flow in the first hour (P <0.05), while Gelofusine * caused a specific, sustained and progressive increase in renal blood flow and conductance (P <0.05). Both fluids increased urine output and creatinine clearance (P <0.05), but, due to haemodilution, both decreased renal oxygen delivery in the first hour (P <0.05). Normal saline and Gelofusine® have transient, volume expansion-related systemic haemodynamic effects, which are greater for Gelofusine®. Saline had a more pronounced early effect on mesenteric blood flow, while Gelofusine * had a sustained and progressive greater effect on renal blood flow. The transient increase in urine output and creatinine clearance seen with both fluids occurred while renal oxygen delivery decreased.
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ISSN:0310-057X
1448-0271
DOI:10.1177/0310057X0703500611