Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway
Chronic hepatitis B virus (HBV) infection remains a serious global health concern. Cisplatin is a chemotherapeutic agent commonly used to treat various cancers. However, HBV-infected patients receiving chemotherapy are at risk of HBV reactivation via unknown mechanisms, which we aimed to elucidate i...
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| Published in: | Free radical biology & medicine Vol. 131; pp. 225 - 236 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier Inc
01.02.2019
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| ISSN: | 0891-5849, 1873-4596, 1873-4596 |
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| Abstract | Chronic hepatitis B virus (HBV) infection remains a serious global health concern. Cisplatin is a chemotherapeutic agent commonly used to treat various cancers. However, HBV-infected patients receiving chemotherapy are at risk of HBV reactivation via unknown mechanisms, which we aimed to elucidate in this study. We found that autophagy plays a central role in cisplatin-induced HBV replication. Cisplatin treatment induced autophagy in both HBV-replicating cells and an HBV-transgenic mouse model as evident from marked upregulation of microtubule-associated protein 1 light chain 3 (LC3)-II and the accumulation of red fluorescent protein (RFP)-LC3 puncta. Cisplatin induced complete autophagic flux, which was detected via monitoring of p62 degradation and RFP-GFP-LC3 expression. Inhibition of autophagy by chloroquine, 3-methyladenine, or Atg5 knockdown significantly attenuated cisplatin-induced HBV replication. Additionally, cisplatin-induced autophagy could be significantly attenuated by using the ROS scavenger N-acetyl-l-cysteine. Mechanically, cisplatin promoted HBV replication and autophagy through ROS/JNK and AKT/mTOR signaling. Inhibition of JNK or activation of Akt/mTOR signaling reversed cisplatin-mediated autophagy and HBV replication promotion. In contrast, suppression of Akt/mTOR signaling further promoted cisplatin-induced HBV replication. Finally, pharmacotherapeutic inhibition of autophagy or ROS production impaired HBV production induced by cisplatin in vivo. Together, our results indicate that ROS/JNK and mTOR/AKT-mediated autophagy plays an important role in cisplatin-induced HBV reactivation.
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•Cisplatin stimulates HBV replication in vitro and in vivo.•Cisplatin induces autophagy to enhance hepatitis B virus replication.•Inhibition of autophagy or ROS/JNK axis rendered cisplatin-induced HBV biosynthesis.•Cisplatin promotes HBV replication and autophagy by ROS/JNK and AKT/mTOR pathway. |
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| AbstractList | Chronic hepatitis B virus (HBV) infection remains a serious global health concern. Cisplatin is a chemotherapeutic agent commonly used to treat various cancers. However, HBV-infected patients receiving chemotherapy are at risk of HBV reactivation via unknown mechanisms, which we aimed to elucidate in this study. We found that autophagy plays a central role in cisplatin-induced HBV replication. Cisplatin treatment induced autophagy in both HBV-replicating cells and an HBV-transgenic mouse model as evident from marked upregulation of microtubule-associated protein 1 light chain 3 (LC3)-II and the accumulation of red fluorescent protein (RFP)-LC3 puncta. Cisplatin induced complete autophagic flux, which was detected via monitoring of p62 degradation and RFP-GFP-LC3 expression. Inhibition of autophagy by chloroquine, 3-methyladenine, or Atg5 knockdown significantly attenuated cisplatin-induced HBV replication. Additionally, cisplatin-induced autophagy could be significantly attenuated by using the ROS scavenger N-acetyl-l-cysteine. Mechanically, cisplatin promoted HBV replication and autophagy through ROS/JNK and AKT/mTOR signaling. Inhibition of JNK or activation of Akt/mTOR signaling reversed cisplatin-mediated autophagy and HBV replication promotion. In contrast, suppression of Akt/mTOR signaling further promoted cisplatin-induced HBV replication. Finally, pharmacotherapeutic inhibition of autophagy or ROS production impaired HBV production induced by cisplatin in vivo. Together, our results indicate that ROS/JNK and mTOR/AKT-mediated autophagy plays an important role in cisplatin-induced HBV reactivation. Chronic hepatitis B virus (HBV) infection remains a serious global health concern. Cisplatin is a chemotherapeutic agent commonly used to treat various cancers. However, HBV-infected patients receiving chemotherapy are at risk of HBV reactivation via unknown mechanisms, which we aimed to elucidate in this study. We found that autophagy plays a central role in cisplatin-induced HBV replication. Cisplatin treatment induced autophagy in both HBV-replicating cells and an HBV-transgenic mouse model as evident from marked upregulation of microtubule-associated protein 1 light chain 3 (LC3)-II and the accumulation of red fluorescent protein (RFP)-LC3 puncta. Cisplatin induced complete autophagic flux, which was detected via monitoring of p62 degradation and RFP-GFP-LC3 expression. Inhibition of autophagy by chloroquine, 3-methyladenine, or Atg5 knockdown significantly attenuated cisplatin-induced HBV replication. Additionally, cisplatin-induced autophagy could be significantly attenuated by using the ROS scavenger N-acetyl-l-cysteine. Mechanically, cisplatin promoted HBV replication and autophagy through ROS/JNK and AKT/mTOR signaling. Inhibition of JNK or activation of Akt/mTOR signaling reversed cisplatin-mediated autophagy and HBV replication promotion. In contrast, suppression of Akt/mTOR signaling further promoted cisplatin-induced HBV replication. Finally, pharmacotherapeutic inhibition of autophagy or ROS production impaired HBV production induced by cisplatin in vivo. Together, our results indicate that ROS/JNK and mTOR/AKT-mediated autophagy plays an important role in cisplatin-induced HBV reactivation.Chronic hepatitis B virus (HBV) infection remains a serious global health concern. Cisplatin is a chemotherapeutic agent commonly used to treat various cancers. However, HBV-infected patients receiving chemotherapy are at risk of HBV reactivation via unknown mechanisms, which we aimed to elucidate in this study. We found that autophagy plays a central role in cisplatin-induced HBV replication. Cisplatin treatment induced autophagy in both HBV-replicating cells and an HBV-transgenic mouse model as evident from marked upregulation of microtubule-associated protein 1 light chain 3 (LC3)-II and the accumulation of red fluorescent protein (RFP)-LC3 puncta. Cisplatin induced complete autophagic flux, which was detected via monitoring of p62 degradation and RFP-GFP-LC3 expression. Inhibition of autophagy by chloroquine, 3-methyladenine, or Atg5 knockdown significantly attenuated cisplatin-induced HBV replication. Additionally, cisplatin-induced autophagy could be significantly attenuated by using the ROS scavenger N-acetyl-l-cysteine. Mechanically, cisplatin promoted HBV replication and autophagy through ROS/JNK and AKT/mTOR signaling. Inhibition of JNK or activation of Akt/mTOR signaling reversed cisplatin-mediated autophagy and HBV replication promotion. In contrast, suppression of Akt/mTOR signaling further promoted cisplatin-induced HBV replication. Finally, pharmacotherapeutic inhibition of autophagy or ROS production impaired HBV production induced by cisplatin in vivo. Together, our results indicate that ROS/JNK and mTOR/AKT-mediated autophagy plays an important role in cisplatin-induced HBV reactivation. Chronic hepatitis B virus (HBV) infection remains a serious global health concern. Cisplatin is a chemotherapeutic agent commonly used to treat various cancers. However, HBV-infected patients receiving chemotherapy are at risk of HBV reactivation via unknown mechanisms, which we aimed to elucidate in this study. We found that autophagy plays a central role in cisplatin-induced HBV replication. Cisplatin treatment induced autophagy in both HBV-replicating cells and an HBV-transgenic mouse model as evident from marked upregulation of microtubule-associated protein 1 light chain 3 (LC3)-II and the accumulation of red fluorescent protein (RFP)-LC3 puncta. Cisplatin induced complete autophagic flux, which was detected via monitoring of p62 degradation and RFP-GFP-LC3 expression. Inhibition of autophagy by chloroquine, 3-methyladenine, or Atg5 knockdown significantly attenuated cisplatin-induced HBV replication. Additionally, cisplatin-induced autophagy could be significantly attenuated by using the ROS scavenger N-acetyl-l-cysteine. Mechanically, cisplatin promoted HBV replication and autophagy through ROS/JNK and AKT/mTOR signaling. Inhibition of JNK or activation of Akt/mTOR signaling reversed cisplatin-mediated autophagy and HBV replication promotion. In contrast, suppression of Akt/mTOR signaling further promoted cisplatin-induced HBV replication. Finally, pharmacotherapeutic inhibition of autophagy or ROS production impaired HBV production induced by cisplatin in vivo. Together, our results indicate that ROS/JNK and mTOR/AKT-mediated autophagy plays an important role in cisplatin-induced HBV reactivation. [Display omitted] •Cisplatin stimulates HBV replication in vitro and in vivo.•Cisplatin induces autophagy to enhance hepatitis B virus replication.•Inhibition of autophagy or ROS/JNK axis rendered cisplatin-induced HBV biosynthesis.•Cisplatin promotes HBV replication and autophagy by ROS/JNK and AKT/mTOR pathway. |
| Author | Li, Xiaosong Zhang, Wenlu Tang, Ni Liang, Li Cai, Xuefei Chen, Xuemei Hu, Jie Hu, Jieli Hu, Yuan Wang, Kai Huang, Ailong Chen, Ke |
| Author_xml | – sequence: 1 givenname: Xuemei surname: Chen fullname: Chen, Xuemei organization: Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China – sequence: 2 givenname: Yuan surname: Hu fullname: Hu, Yuan organization: Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China – sequence: 3 givenname: Wenlu surname: Zhang fullname: Zhang, Wenlu organization: Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China – sequence: 4 givenname: Ke surname: Chen fullname: Chen, Ke organization: Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China – sequence: 5 givenname: Jie surname: Hu fullname: Hu, Jie organization: Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China – sequence: 6 givenname: Xiaosong surname: Li fullname: Li, Xiaosong organization: The First Affiliated Hospital, Chongqing Medical University, Chongqing, China – sequence: 7 givenname: Li surname: Liang fullname: Liang, Li organization: Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China – sequence: 8 givenname: Xuefei surname: Cai fullname: Cai, Xuefei organization: Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China – sequence: 9 givenname: Jieli surname: Hu fullname: Hu, Jieli organization: Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China – sequence: 10 givenname: Kai orcidid: 0000-0002-0137-1247 surname: Wang fullname: Wang, Kai email: wangkai@cqmu.edu.cn organization: Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China – sequence: 11 givenname: Ailong surname: Huang fullname: Huang, Ailong email: ahuang@cqu.edu.cn organization: Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China – sequence: 12 givenname: Ni surname: Tang fullname: Tang, Ni email: nitang@cqmu.edu.cn organization: Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China |
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| Cites_doi | 10.1016/j.ccr.2006.08.015 10.1038/s41579-018-0003-6 10.1093/cid/ciw043 10.1093/annonc/mdh430 10.1080/15548627.2016.1191857 10.1038/317489a0 10.4161/auto.4451 10.1038/cddis.2015.409 10.1016/S0140-6736(77)91995-X 10.1038/srep05029 10.1128/JVI.02627-10 10.1053/j.gastro.2017.02.009 10.1080/15548627.2018.1458805 10.1016/j.ceb.2009.11.014 10.1053/j.gastro.2017.11.011 10.4161/auto.5528 10.1080/15548627.2016.1278094 10.1038/s41598-018-21847-3 10.1016/j.chom.2010.01.007 10.1016/j.freeradbiomed.2017.02.015 10.1002/hep.22581 10.1073/pnas.0911373107 10.1016/j.immuni.2012.03.003 10.1158/1535-7163.MCT-11-0047 10.3892/or.2016.4782 10.1038/s41580-018-0003-4 10.1007/s10571-015-0166-x 10.1016/j.cell.2010.01.028 10.1038/nrm2239 10.18632/aging.101534 10.1038/srep27071 10.1016/j.bbrc.2018.03.089 10.1016/j.freeradbiomed.2010.03.020 10.3390/nu10081043 10.1016/j.lfs.2017.07.024 10.1128/JVI.00316-11 10.3748/wjg.v22.i1.176 10.1371/journal.pone.0087161 10.5582/bst.2016.01049 10.1074/jbc.M114.558288 10.1128/JVI.00001-17 10.1002/hep.23163 10.1016/S0140-6736(75)90897-1 10.1242/jcs.094573 10.1038/cddis.2017.303 10.1016/j.antiviral.2017.11.006 10.1128/JVI.75.3.1104-1116.2001 10.1371/journal.pone.0197109 10.1053/jhep.2003.50220 10.3390/v1020185 10.3851/IMP1840 10.4161/auto.27286 10.1038/ncb0910-823 10.1006/scbi.2000.0321 |
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| Keywords | Hepatitis B virus replication ALT MDA Autophagy CQ Cisplatin NAC LC3II pgRNA ROS 3-MA Hepatitis B virus reactivation HBV RFP SQSTM1 ROS/JNK signaling pathway |
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| References | Loomba, Liang, Hepatitis (bib7) 2017; 152 Klein, Jackson (bib42) 2011; 85 Nagington (bib6) 1977; 1 Choi, Bowman, Jung (bib41) 2018; 16 Galbraith, Eddleston, Williams, Zuckerman (bib5) 1975; 2 Liu, Chuang, Sheen, Wang, Chen, Tseng, Chang, Massetto, Yang, Yun, Knox, Osinusi, Camus, Jiang, Brainard, McHutchison, Hu, Hsu, Lo, Chu, Chen, Peng, Chien, Chen (bib37) 2018; 154 Dikic, Elazar (bib3) 2018; 19 Peng, Qiu, Xu, Zhang, Yu, Ding, Deng, Lin (bib13) 2017; 185 Wang, Yeh, Lin, Wang, Chen, Chen (bib17) 2009; 50 Mizushima, Yoshimori, Levine (bib31) 2010; 140 Jang, Kwon, You, Kim, Woo, Bae, Choi, Yoon, Chung (bib9) 2011; 16 Zhou, Jin, Ding, Zhang, Sun, Huang, Xie, Xu, Cai (bib47) 2016; 10 Ma, Zhang, Huang, Li, Hu (bib34) 2016; 36 Wu, Lan, Liu (bib44) 2016; 22 Schadler, Hildt (bib4) 2009; 1 Saito, Nah, Oka, Mukai, Monden, Maejima, Ikeda, Sciarretta, Liu, Li, Baljinnyam, Fraidenraich, Fritzky, Zhai, Ichinose, Isobe, Hsu, Kundu, Sadoshima (bib12) 2018 Datan, Roy, Germain, Zali, McLean, Golshan, Harbajan, Lockshin, Zakeri (bib53) 2016; 7 Li, Tan, Miao, Lei, Zhang (bib50) 2015; 35 Chen, Hu, Cai, Huang, Zhou, Tu, Hu, Tavis, Tang, Huang, Hu (bib19) 2018; 149 Qian, Liu, Hu, Gan, Hou, Chen, Huang (bib20) 2017; 8 Yuan, Huang, Fox, Laturnus, Carlson, Zhang, Yin, Gao, Wu (bib16) 2012; 125 Mizushima, Levine (bib28) 2010; 12 Jung, Pyo, Choi (bib54) 2018; 498 Yeo, Lam, Zee, Chan, Mo, Ho, Wong, Leung, Chan, Ma, Mok, Johnson (bib10) 2004; 15 Hernandez-Garcia, Wood, Castro-Obregon, Covarrubias (bib49) 2010; 49 Tiollais, Pourcel, Dejean (bib2) 1985; 317 Gonzalez, Perrillo, Hepatitis, Virus (bib8) 2016; 62 Liu, Fang, Hu, Huang, Li, Chang, Huang, Xu, Yang, Chen, Liu (bib46) 2014; 10 Wang, Zhang, Sun, Wang, Yin, Wang, Zuo, Sun, Zhou, Lin, Xu, Hua, Li, Cai (bib32) 2017; 106 Lee, Gowda Saralamma, Kim, Ha, Raha, Lee, Kim, Lee, Heo, Kim (bib35) 2018; 10 Wang, Zhang, Peng, Zhou, Zhong, Chen, Qiu, Jin, Gong, Kong (bib55) 2016; 6 Zhu, Hu, Wu, Hu (bib22) 2014; 4 Brechot, Gozuacik, Murakami, Paterlini-Brechot (bib1) 2000; 10 Xie, Yuan, Zhou, Wang, Chen, Lei, Lan, Pu, Gao, Zhang, Shen, Li, Xiao, Tang, Xiang, He, Feng, Nice, Wei, Zhang, Yang, Huang (bib21) 2016; 12 Gao, Zhao, Wu, Wu, Tian, Zhang (bib36) 2018; 10 Cheng, Hsiung, Su, Chen, Chang, Tsao, Kao, Uen, Hsu, Tien, Chao, Chen, Whang-Peng (bib11) 2003; 37 Schumacker (bib33) 2006; 10 Moore (bib51) 2008; 4 Nakamoto, Moy, Xu, Bambina, Yasunaga, Shelly, Gold, Cherry (bib39) 2012; 36 Tang, Da, Mao, Li, Li, Xu, Li, Wang, Tiollais, Li, Zhao (bib43) 2009; 49 Zhou, Farah, Sinha, Wu, Singh, Bay, Yang, Yen (bib27) 2014; 9 Maiuri, Zalckvar, Kimchi, Kroemer (bib29) 2007; 8 Orvedahl, MacPherson, Sumpter, Talloczy, Zou, Levine (bib38) 2010; 7 Li, Pan, Zhu, Xu, Chen, Li, Liang, Hu, Xia, Chen, Chen, Hu, Wang, Tang, Huang (bib18) 2018; 8 Yang, Klionsky (bib24) 2010; 22 Sir, Tian, Chen, Ann, Yen, Ou (bib23) 2010; 107 Wang, Wu (bib14) 2014; 289 Elizalde, Perez, Sevic, Grasso, Ropolo, Barbini, Campos, Vaccaro, Flichman (bib45) 2018; 13 Ren, Nassal (bib15) 2001; 75 Velazquez, Corona, Klein, Jackson (bib40) 2018; 14 Zhong, Shu, Dai, Gao, Xiong (bib52) 2017; 91 Kimura, Noda, Yoshimori (bib25) 2014; 3 Morishita, Kaizuka, Hama, Mizushima (bib26) 2017; 13 Yang, Chee, Huang, Sinicrope (bib30) 2011; 10 Li, Liu, Wang, Liu, Wang, Liu, Ding, Yuan (bib48) 2011; 85 Yuan (10.1016/j.freeradbiomed.2018.12.008_bib16) 2012; 125 Liu (10.1016/j.freeradbiomed.2018.12.008_bib46) 2014; 10 Wang (10.1016/j.freeradbiomed.2018.12.008_bib55) 2016; 6 Ma (10.1016/j.freeradbiomed.2018.12.008_bib34) 2016; 36 Wang (10.1016/j.freeradbiomed.2018.12.008_bib17) 2009; 50 Velazquez (10.1016/j.freeradbiomed.2018.12.008_bib40) 2018; 14 Zhou (10.1016/j.freeradbiomed.2018.12.008_bib47) 2016; 10 Maiuri (10.1016/j.freeradbiomed.2018.12.008_bib29) 2007; 8 Mizushima (10.1016/j.freeradbiomed.2018.12.008_bib28) 2010; 12 Schumacker (10.1016/j.freeradbiomed.2018.12.008_bib33) 2006; 10 Moore (10.1016/j.freeradbiomed.2018.12.008_bib51) 2008; 4 Galbraith (10.1016/j.freeradbiomed.2018.12.008_bib5) 1975; 2 Sir (10.1016/j.freeradbiomed.2018.12.008_bib23) 2010; 107 Yang (10.1016/j.freeradbiomed.2018.12.008_bib24) 2010; 22 Klein (10.1016/j.freeradbiomed.2018.12.008_bib42) 2011; 85 Nakamoto (10.1016/j.freeradbiomed.2018.12.008_bib39) 2012; 36 Morishita (10.1016/j.freeradbiomed.2018.12.008_bib26) 2017; 13 Kimura (10.1016/j.freeradbiomed.2018.12.008_bib25) 2014; 3 Choi (10.1016/j.freeradbiomed.2018.12.008_bib41) 2018; 16 Zhong (10.1016/j.freeradbiomed.2018.12.008_bib52) 2017; 91 Wang (10.1016/j.freeradbiomed.2018.12.008_bib14) 2014; 289 Gao (10.1016/j.freeradbiomed.2018.12.008_bib36) 2018; 10 Zhu (10.1016/j.freeradbiomed.2018.12.008_bib22) 2014; 4 Saito (10.1016/j.freeradbiomed.2018.12.008_bib12) 2018 Xie (10.1016/j.freeradbiomed.2018.12.008_bib21) 2016; 12 Wu (10.1016/j.freeradbiomed.2018.12.008_bib44) 2016; 22 Yang (10.1016/j.freeradbiomed.2018.12.008_bib30) 2011; 10 Jung (10.1016/j.freeradbiomed.2018.12.008_bib54) 2018; 498 Gonzalez (10.1016/j.freeradbiomed.2018.12.008_bib8) 2016; 62 Ren (10.1016/j.freeradbiomed.2018.12.008_bib15) 2001; 75 Tiollais (10.1016/j.freeradbiomed.2018.12.008_bib2) 1985; 317 Dikic (10.1016/j.freeradbiomed.2018.12.008_bib3) 2018; 19 Cheng (10.1016/j.freeradbiomed.2018.12.008_bib11) 2003; 37 Li (10.1016/j.freeradbiomed.2018.12.008_bib48) 2011; 85 Brechot (10.1016/j.freeradbiomed.2018.12.008_bib1) 2000; 10 Yeo (10.1016/j.freeradbiomed.2018.12.008_bib10) 2004; 15 Nagington (10.1016/j.freeradbiomed.2018.12.008_bib6) 1977; 1 Wang (10.1016/j.freeradbiomed.2018.12.008_bib32) 2017; 106 Peng (10.1016/j.freeradbiomed.2018.12.008_bib13) 2017; 185 Qian (10.1016/j.freeradbiomed.2018.12.008_bib20) 2017; 8 Tang (10.1016/j.freeradbiomed.2018.12.008_bib43) 2009; 49 Zhou (10.1016/j.freeradbiomed.2018.12.008_bib27) 2014; 9 Lee (10.1016/j.freeradbiomed.2018.12.008_bib35) 2018; 10 Schadler (10.1016/j.freeradbiomed.2018.12.008_bib4) 2009; 1 Li (10.1016/j.freeradbiomed.2018.12.008_bib50) 2015; 35 Li (10.1016/j.freeradbiomed.2018.12.008_bib18) 2018; 8 Loomba (10.1016/j.freeradbiomed.2018.12.008_bib7) 2017; 152 Elizalde (10.1016/j.freeradbiomed.2018.12.008_bib45) 2018; 13 Chen (10.1016/j.freeradbiomed.2018.12.008_bib19) 2018; 149 Mizushima (10.1016/j.freeradbiomed.2018.12.008_bib31) 2010; 140 Jang (10.1016/j.freeradbiomed.2018.12.008_bib9) 2011; 16 Hernandez-Garcia (10.1016/j.freeradbiomed.2018.12.008_bib49) 2010; 49 Liu (10.1016/j.freeradbiomed.2018.12.008_bib37) 2018; 154 Datan (10.1016/j.freeradbiomed.2018.12.008_bib53) 2016; 7 Orvedahl (10.1016/j.freeradbiomed.2018.12.008_bib38) 2010; 7 |
| References_xml | – volume: 50 start-page: 1392 year: 2009 end-page: 1402 ident: bib17 article-title: Identification of androgen response elements in the enhancer I of hepatitis B virus: a mechanism for sex disparity in chronic hepatitis B publication-title: Hepatology – volume: 8 start-page: 741 year: 2007 end-page: 752 ident: bib29 article-title: Self-eating and self-killing: crosstalk between autophagy and apoptosis publication-title: Nat. Rev. Mol. Cell Biol. – volume: 6 start-page: 27071 year: 2016 ident: bib55 article-title: Stellettin B induces G1 arrest, apoptosis and autophagy in human non-small cell lung cancer A549 cells via blocking PI3K/Akt/mTOR pathway publication-title: Sci. Rep. – volume: 75 start-page: 1104 year: 2001 end-page: 1116 ident: bib15 article-title: Hepatitis B virus (HBV) virion and covalently closed circular DNA formation in primary tupaia hepatocytes and human hepatoma cell lines upon HBV genome transduction with replication-defective adenovirus vectors publication-title: J. Virol. – volume: 22 start-page: 176 year: 2016 end-page: 187 ident: bib44 article-title: Autophagy and microRNA in hepatitis B virus-related hepatocellular carcinoma publication-title: World J. Gastroenterol. – year: 2018 ident: bib12 article-title: An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia publication-title: J. Clin. Investig. – volume: 10 start-page: 1533 year: 2011 end-page: 1541 ident: bib30 article-title: The role of autophagy in cancer: therapeutic implications publication-title: Mol. Cancer Ther. – volume: 7 start-page: e2127 year: 2016 ident: bib53 article-title: Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation publication-title: Cell Death Dis. – volume: 9 start-page: e87161 year: 2014 ident: bib27 article-title: Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance publication-title: PLoS One – volume: 8 start-page: e2909 year: 2017 ident: bib20 article-title: Ochratoxin A-induced autophagy in vitro and in vivo promotes porcine circovirus type 2 replication publication-title: Cell Death Dis. – volume: 498 start-page: 960 year: 2018 end-page: 966 ident: bib54 article-title: Influenza A virus-induced autophagy contributes to enhancement of virus infectivity by SOD1 downregulation in alveolar epithelial cells publication-title: Biochem. Biophys. Res. Commun. – volume: 62 start-page: S306 year: 2016 end-page: S313 ident: bib8 article-title: Reactivation in the setting of cancer chemotherapy and other immunosuppressive drug therapy publication-title: Clin. Infect. Dis.: Off. Publ. Infect. Dis. Soc. Am. – volume: 3 start-page: 452 year: 2014 end-page: 460 ident: bib25 article-title: Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3 publication-title: Autophagy – volume: 10 start-page: E1043 year: 2018 ident: bib35 article-title: Pectolinarigenin induced cell cycle arrest, autophagy, and apoptosis in gastric cancer cell via PI3K/AKT/mTOR signaling pathway publication-title: Nutrients – volume: 13 start-page: 757 year: 2017 end-page: 758 ident: bib26 article-title: A new probe to measure autophagic flux in vitro and in vivo publication-title: Autophagy – volume: 16 start-page: 341 year: 2018 end-page: 354 ident: bib41 article-title: Autophagy during viral infection – a double-edged sword publication-title: Nat. Rev. Microbiol. – volume: 7 start-page: 115 year: 2010 end-page: 127 ident: bib38 article-title: Autophagy protects against Sindbis virus infection of the central nervous system publication-title: Cell Host Microbe – volume: 4 start-page: 254 year: 2008 end-page: 256 ident: bib51 article-title: Autophagy as a second level protective process in conferring resistance to environmentally-induced oxidative stress publication-title: Autophagy – volume: 4 start-page: 5029 year: 2014 ident: bib22 article-title: No evident dose-response relationship between cellular ROS level and its cytotoxicity – a paradoxical issue in ROS-based cancer therapy publication-title: Sci. Rep. – volume: 12 start-page: 823 year: 2010 end-page: 830 ident: bib28 article-title: Autophagy in mammalian development and differentiation publication-title: Nat. Cell Biol. – volume: 10 start-page: 244 year: 2016 end-page: 250 ident: bib47 article-title: Hepatitis B virus dampens autophagy maturation via negative regulation of Rab7 expression publication-title: Biosci. Trends – volume: 154 start-page: 989 year: 2018 end-page: 997 ident: bib37 article-title: Efficacy of ledipasvir and sofosbuvir treatment of HCV infection in patients coinfected with HBV publication-title: Gastroenterology – volume: 1 start-page: 185 year: 2009 end-page: 209 ident: bib4 article-title: HBV life cycle: entry and morphogenesis publication-title: Viruses – volume: 140 start-page: 313 year: 2010 end-page: 326 ident: bib31 article-title: Methods in mammalian autophagy research publication-title: Cell – volume: 15 start-page: 1661 year: 2004 end-page: 1666 ident: bib10 article-title: Hepatitis B reactivation in patients with hepatocellular carcinoma undergoing systemic chemotherapy publication-title: Ann. Oncol.: Off. J. Eur. Soc. Med. Oncol. – volume: 14 start-page: 1201 year: 2018 end-page: 1213 ident: bib40 article-title: Poliovirus induces autophagic signaling independent of the ULK1 complex publication-title: Autophagy – volume: 317 start-page: 489 year: 1985 end-page: 495 ident: bib2 article-title: The hepatitis B virus publication-title: Nature – volume: 10 start-page: 175 year: 2006 end-page: 176 ident: bib33 article-title: Reactive oxygen species in cancer cells: live by the sword, die by the sword publication-title: Cancer Cell – volume: 152 start-page: 1297 year: 2017 end-page: 1309 ident: bib7 article-title: B reactivation associated With immune suppressive and biological modifier therapies: current concepts, management strategies, and future directions publication-title: Gastroenterology – volume: 149 start-page: 16 year: 2018 end-page: 25 ident: bib19 article-title: APOBEC3B edits HBV DNA and inhibits HBV replication during reverse transcription publication-title: Antivir. Res. – volume: 19 start-page: 349 year: 2018 end-page: 364 ident: bib3 article-title: Mechanism and medical implications of mammalian autophagy publication-title: Nat. Rev. Mol. Cell Biol. – volume: 49 start-page: 130 year: 2010 end-page: 143 ident: bib49 article-title: Reactive oxygen species: a radical role in development? publication-title: Free Radic. Biol. Med. – volume: 185 start-page: 63 year: 2017 end-page: 72 ident: bib13 article-title: M4IDP, a zoledronic acid derivative, induces G1 arrest, apoptosis and autophagy in HCT116 colon carcinoma cells via blocking PI3K/Akt/mTOR pathway publication-title: Life Sci. – volume: 106 start-page: 24 year: 2017 end-page: 37 ident: bib32 article-title: Arsenic sulfide induces apoptosis and autophagy through the activation of ROS/JNK and suppression of Akt/mTOR signaling pathways in osteosarcoma publication-title: Free Radic. Biol. Med. – volume: 35 start-page: 615 year: 2015 end-page: 621 ident: bib50 article-title: ROS and autophagy: interactions and molecular regulatory mechanisms publication-title: Cell. Mol. Neurobiol. – volume: 91 year: 2017 ident: bib52 article-title: Reactive oxygen species-mediated c-Jun NH2-terminal kinase activation contributes to hepatitis B virus X protein-induced autophagy via regulation of the Beclin-1/Bcl-2 interaction publication-title: J. Virol. – volume: 1 start-page: 558 year: 1977 end-page: 560 ident: bib6 article-title: Reactivation of hepatitis b after transplantation operations publication-title: Lancet – volume: 37 start-page: 1320 year: 2003 end-page: 1328 ident: bib11 article-title: Steroid-free chemotherapy decreases risk of hepatitis B virus (HBV) reactivation in HBV-carriers with lymphoma publication-title: Hepatology – volume: 10 start-page: 416 year: 2014 end-page: 430 ident: bib46 article-title: Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation publication-title: Autophagy – volume: 10 start-page: 211 year: 2000 end-page: 231 ident: bib1 article-title: Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) publication-title: Semin. Cancer Biol. – volume: 85 start-page: 6319 year: 2011 end-page: 6333 ident: bib48 article-title: Subversion of cellular autophagy machinery by hepatitis B virus for viral envelopment publication-title: J. Virol. – volume: 49 start-page: 60 year: 2009 end-page: 71 ident: bib43 article-title: Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via up-regulation of beclin 1 expression publication-title: Hepatology – volume: 2 start-page: 528 year: 1975 end-page: 530 ident: bib5 article-title: Fulminant hepatic failure in leukaemia and choriocarcinoma related to withdrawal of cytotoxic drug therapy publication-title: Lancet – volume: 85 start-page: 9651 year: 2011 end-page: 9654 ident: bib42 article-title: Human rhinovirus 2 induces the autophagic pathway and replicates more efficiently in autophagic cells publication-title: J. Virol. – volume: 13 start-page: e0197109 year: 2018 ident: bib45 article-title: HBV subgenotypes F1b and F4 replication induces an incomplete autophagic process in hepatocytes: role of BCP and preCore mutations publication-title: PLoS One – volume: 36 start-page: 658 year: 2012 end-page: 667 ident: bib39 article-title: Virus recognition by Toll-7 activates antiviral autophagy in Drosophila publication-title: Immunity – volume: 36 start-page: 90 year: 2016 end-page: 98 ident: bib34 article-title: Cinobufagin induces autophagy-mediated cell death in human osteosarcoma U2OS cells through the ROS/JNK/p38 signaling pathway publication-title: Oncol. Rep. – volume: 125 start-page: 507 year: 2012 end-page: 515 ident: bib16 article-title: Autophagy plays an essential role in the clearance of Pseudomonas aeruginosa by alveolar macrophages publication-title: J. Cell Sci. – volume: 8 start-page: 3496 year: 2018 ident: bib18 article-title: Cisplatin enhances hepatitis B virus replication and PGC-1alpha expression through endoplasmic reticulum stress publication-title: Sci. Rep. – volume: 107 start-page: 4383 year: 2010 end-page: 4388 ident: bib23 article-title: The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication publication-title: Proc. Natl. Acad. Sci. USA – volume: 12 start-page: 1507 year: 2016 end-page: 1520 ident: bib21 article-title: PRKAA/AMPK restricts HBV replication through promotion of autophagic degradation publication-title: Autophagy – volume: 10 start-page: 2113 year: 2018 end-page: 2121 ident: bib36 article-title: MiR-146b inhibits autophagy in prostate cancer by targeting the PTEN/Akt/mTOR signaling pathway publication-title: Aging – volume: 16 start-page: 969 year: 2011 end-page: 977 ident: bib9 article-title: Risk of HBV reactivation according to viral status and treatment intensity in patients with hepatocellular carcinoma publication-title: Antivir. Ther. – volume: 22 start-page: 124 year: 2010 end-page: 131 ident: bib24 article-title: Mammalian autophagy: core molecular machinery and signaling regulation publication-title: Curr. Opin. Cell Biol. – volume: 289 start-page: 17163 year: 2014 end-page: 17173 ident: bib14 article-title: Role of autophagy in cisplatin resistance in ovarian cancer cells publication-title: J. Biol. Chem. – volume: 10 start-page: 175 issue: 3 year: 2006 ident: 10.1016/j.freeradbiomed.2018.12.008_bib33 article-title: Reactive oxygen species in cancer cells: live by the sword, die by the sword publication-title: Cancer Cell doi: 10.1016/j.ccr.2006.08.015 – volume: 16 start-page: 341 issue: 6 year: 2018 ident: 10.1016/j.freeradbiomed.2018.12.008_bib41 article-title: Autophagy during viral infection – a double-edged sword publication-title: Nat. Rev. Microbiol. doi: 10.1038/s41579-018-0003-6 – volume: 62 start-page: S306 issue: Suppl. 4 year: 2016 ident: 10.1016/j.freeradbiomed.2018.12.008_bib8 article-title: Reactivation in the setting of cancer chemotherapy and other immunosuppressive drug therapy publication-title: Clin. Infect. Dis.: Off. Publ. Infect. Dis. Soc. Am. doi: 10.1093/cid/ciw043 – volume: 15 start-page: 1661 issue: 11 year: 2004 ident: 10.1016/j.freeradbiomed.2018.12.008_bib10 article-title: Hepatitis B reactivation in patients with hepatocellular carcinoma undergoing systemic chemotherapy publication-title: Ann. Oncol.: Off. J. Eur. Soc. Med. Oncol. doi: 10.1093/annonc/mdh430 – volume: 12 start-page: 1507 issue: 9 year: 2016 ident: 10.1016/j.freeradbiomed.2018.12.008_bib21 article-title: PRKAA/AMPK restricts HBV replication through promotion of autophagic degradation publication-title: Autophagy doi: 10.1080/15548627.2016.1191857 – volume: 317 start-page: 489 issue: 6037 year: 1985 ident: 10.1016/j.freeradbiomed.2018.12.008_bib2 article-title: The hepatitis B virus publication-title: Nature doi: 10.1038/317489a0 – volume: 3 start-page: 452 issue: 5 year: 2014 ident: 10.1016/j.freeradbiomed.2018.12.008_bib25 article-title: Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3 publication-title: Autophagy doi: 10.4161/auto.4451 – volume: 7 start-page: e2127 year: 2016 ident: 10.1016/j.freeradbiomed.2018.12.008_bib53 article-title: Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation publication-title: Cell Death Dis. doi: 10.1038/cddis.2015.409 – volume: 1 start-page: 558 issue: 8011 year: 1977 ident: 10.1016/j.freeradbiomed.2018.12.008_bib6 article-title: Reactivation of hepatitis b after transplantation operations publication-title: Lancet doi: 10.1016/S0140-6736(77)91995-X – volume: 4 start-page: 5029 year: 2014 ident: 10.1016/j.freeradbiomed.2018.12.008_bib22 article-title: No evident dose-response relationship between cellular ROS level and its cytotoxicity – a paradoxical issue in ROS-based cancer therapy publication-title: Sci. Rep. doi: 10.1038/srep05029 – volume: 85 start-page: 6319 issue: 13 year: 2011 ident: 10.1016/j.freeradbiomed.2018.12.008_bib48 article-title: Subversion of cellular autophagy machinery by hepatitis B virus for viral envelopment publication-title: J. Virol. doi: 10.1128/JVI.02627-10 – volume: 152 start-page: 1297 issue: 6 year: 2017 ident: 10.1016/j.freeradbiomed.2018.12.008_bib7 article-title: B reactivation associated With immune suppressive and biological modifier therapies: current concepts, management strategies, and future directions publication-title: Gastroenterology doi: 10.1053/j.gastro.2017.02.009 – volume: 14 start-page: 1201 issue: 7 year: 2018 ident: 10.1016/j.freeradbiomed.2018.12.008_bib40 article-title: Poliovirus induces autophagic signaling independent of the ULK1 complex publication-title: Autophagy doi: 10.1080/15548627.2018.1458805 – volume: 22 start-page: 124 issue: 2 year: 2010 ident: 10.1016/j.freeradbiomed.2018.12.008_bib24 article-title: Mammalian autophagy: core molecular machinery and signaling regulation publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2009.11.014 – volume: 154 start-page: 989 issue: 4 year: 2018 ident: 10.1016/j.freeradbiomed.2018.12.008_bib37 article-title: Efficacy of ledipasvir and sofosbuvir treatment of HCV infection in patients coinfected with HBV publication-title: Gastroenterology doi: 10.1053/j.gastro.2017.11.011 – volume: 4 start-page: 254 issue: 2 year: 2008 ident: 10.1016/j.freeradbiomed.2018.12.008_bib51 article-title: Autophagy as a second level protective process in conferring resistance to environmentally-induced oxidative stress publication-title: Autophagy doi: 10.4161/auto.5528 – volume: 13 start-page: 757 issue: 4 year: 2017 ident: 10.1016/j.freeradbiomed.2018.12.008_bib26 article-title: A new probe to measure autophagic flux in vitro and in vivo publication-title: Autophagy doi: 10.1080/15548627.2016.1278094 – volume: 8 start-page: 3496 issue: 1 year: 2018 ident: 10.1016/j.freeradbiomed.2018.12.008_bib18 article-title: Cisplatin enhances hepatitis B virus replication and PGC-1alpha expression through endoplasmic reticulum stress publication-title: Sci. Rep. doi: 10.1038/s41598-018-21847-3 – volume: 7 start-page: 115 issue: 2 year: 2010 ident: 10.1016/j.freeradbiomed.2018.12.008_bib38 article-title: Autophagy protects against Sindbis virus infection of the central nervous system publication-title: Cell Host Microbe doi: 10.1016/j.chom.2010.01.007 – volume: 106 start-page: 24 year: 2017 ident: 10.1016/j.freeradbiomed.2018.12.008_bib32 article-title: Arsenic sulfide induces apoptosis and autophagy through the activation of ROS/JNK and suppression of Akt/mTOR signaling pathways in osteosarcoma publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2017.02.015 – volume: 49 start-page: 60 issue: 1 year: 2009 ident: 10.1016/j.freeradbiomed.2018.12.008_bib43 article-title: Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via up-regulation of beclin 1 expression publication-title: Hepatology doi: 10.1002/hep.22581 – volume: 107 start-page: 4383 issue: 9 year: 2010 ident: 10.1016/j.freeradbiomed.2018.12.008_bib23 article-title: The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0911373107 – volume: 36 start-page: 658 issue: 4 year: 2012 ident: 10.1016/j.freeradbiomed.2018.12.008_bib39 article-title: Virus recognition by Toll-7 activates antiviral autophagy in Drosophila publication-title: Immunity doi: 10.1016/j.immuni.2012.03.003 – volume: 10 start-page: 1533 issue: 9 year: 2011 ident: 10.1016/j.freeradbiomed.2018.12.008_bib30 article-title: The role of autophagy in cancer: therapeutic implications publication-title: Mol. Cancer Ther. doi: 10.1158/1535-7163.MCT-11-0047 – volume: 36 start-page: 90 issue: 1 year: 2016 ident: 10.1016/j.freeradbiomed.2018.12.008_bib34 article-title: Cinobufagin induces autophagy-mediated cell death in human osteosarcoma U2OS cells through the ROS/JNK/p38 signaling pathway publication-title: Oncol. Rep. doi: 10.3892/or.2016.4782 – volume: 19 start-page: 349 issue: 6 year: 2018 ident: 10.1016/j.freeradbiomed.2018.12.008_bib3 article-title: Mechanism and medical implications of mammalian autophagy publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/s41580-018-0003-4 – volume: 35 start-page: 615 issue: 5 year: 2015 ident: 10.1016/j.freeradbiomed.2018.12.008_bib50 article-title: ROS and autophagy: interactions and molecular regulatory mechanisms publication-title: Cell. Mol. Neurobiol. doi: 10.1007/s10571-015-0166-x – volume: 140 start-page: 313 issue: 3 year: 2010 ident: 10.1016/j.freeradbiomed.2018.12.008_bib31 article-title: Methods in mammalian autophagy research publication-title: Cell doi: 10.1016/j.cell.2010.01.028 – volume: 8 start-page: 741 issue: 9 year: 2007 ident: 10.1016/j.freeradbiomed.2018.12.008_bib29 article-title: Self-eating and self-killing: crosstalk between autophagy and apoptosis publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm2239 – volume: 10 start-page: 2113 issue: 8 year: 2018 ident: 10.1016/j.freeradbiomed.2018.12.008_bib36 article-title: MiR-146b inhibits autophagy in prostate cancer by targeting the PTEN/Akt/mTOR signaling pathway publication-title: Aging doi: 10.18632/aging.101534 – volume: 6 start-page: 27071 year: 2016 ident: 10.1016/j.freeradbiomed.2018.12.008_bib55 article-title: Stellettin B induces G1 arrest, apoptosis and autophagy in human non-small cell lung cancer A549 cells via blocking PI3K/Akt/mTOR pathway publication-title: Sci. Rep. doi: 10.1038/srep27071 – volume: 498 start-page: 960 issue: 4 year: 2018 ident: 10.1016/j.freeradbiomed.2018.12.008_bib54 article-title: Influenza A virus-induced autophagy contributes to enhancement of virus infectivity by SOD1 downregulation in alveolar epithelial cells publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2018.03.089 – volume: 49 start-page: 130 issue: 2 year: 2010 ident: 10.1016/j.freeradbiomed.2018.12.008_bib49 article-title: Reactive oxygen species: a radical role in development? publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2010.03.020 – volume: 10 start-page: E1043 issue: 8 year: 2018 ident: 10.1016/j.freeradbiomed.2018.12.008_bib35 article-title: Pectolinarigenin induced cell cycle arrest, autophagy, and apoptosis in gastric cancer cell via PI3K/AKT/mTOR signaling pathway publication-title: Nutrients doi: 10.3390/nu10081043 – volume: 185 start-page: 63 year: 2017 ident: 10.1016/j.freeradbiomed.2018.12.008_bib13 article-title: M4IDP, a zoledronic acid derivative, induces G1 arrest, apoptosis and autophagy in HCT116 colon carcinoma cells via blocking PI3K/Akt/mTOR pathway publication-title: Life Sci. doi: 10.1016/j.lfs.2017.07.024 – volume: 85 start-page: 9651 issue: 18 year: 2011 ident: 10.1016/j.freeradbiomed.2018.12.008_bib42 article-title: Human rhinovirus 2 induces the autophagic pathway and replicates more efficiently in autophagic cells publication-title: J. Virol. doi: 10.1128/JVI.00316-11 – volume: 22 start-page: 176 issue: 1 year: 2016 ident: 10.1016/j.freeradbiomed.2018.12.008_bib44 article-title: Autophagy and microRNA in hepatitis B virus-related hepatocellular carcinoma publication-title: World J. Gastroenterol. doi: 10.3748/wjg.v22.i1.176 – volume: 9 start-page: e87161 issue: 1 year: 2014 ident: 10.1016/j.freeradbiomed.2018.12.008_bib27 article-title: Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance publication-title: PLoS One doi: 10.1371/journal.pone.0087161 – volume: 10 start-page: 244 issue: 4 year: 2016 ident: 10.1016/j.freeradbiomed.2018.12.008_bib47 article-title: Hepatitis B virus dampens autophagy maturation via negative regulation of Rab7 expression publication-title: Biosci. Trends doi: 10.5582/bst.2016.01049 – volume: 289 start-page: 17163 issue: 24 year: 2014 ident: 10.1016/j.freeradbiomed.2018.12.008_bib14 article-title: Role of autophagy in cisplatin resistance in ovarian cancer cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.M114.558288 – volume: 91 issue: 15 year: 2017 ident: 10.1016/j.freeradbiomed.2018.12.008_bib52 article-title: Reactive oxygen species-mediated c-Jun NH2-terminal kinase activation contributes to hepatitis B virus X protein-induced autophagy via regulation of the Beclin-1/Bcl-2 interaction publication-title: J. Virol. doi: 10.1128/JVI.00001-17 – volume: 50 start-page: 1392 issue: 5 year: 2009 ident: 10.1016/j.freeradbiomed.2018.12.008_bib17 article-title: Identification of androgen response elements in the enhancer I of hepatitis B virus: a mechanism for sex disparity in chronic hepatitis B publication-title: Hepatology doi: 10.1002/hep.23163 – volume: 2 start-page: 528 issue: 7934 year: 1975 ident: 10.1016/j.freeradbiomed.2018.12.008_bib5 article-title: Fulminant hepatic failure in leukaemia and choriocarcinoma related to withdrawal of cytotoxic drug therapy publication-title: Lancet doi: 10.1016/S0140-6736(75)90897-1 – volume: 125 start-page: 507 issue: Pt 2 year: 2012 ident: 10.1016/j.freeradbiomed.2018.12.008_bib16 article-title: Autophagy plays an essential role in the clearance of Pseudomonas aeruginosa by alveolar macrophages publication-title: J. Cell Sci. doi: 10.1242/jcs.094573 – volume: 8 start-page: e2909 issue: 6 year: 2017 ident: 10.1016/j.freeradbiomed.2018.12.008_bib20 article-title: Ochratoxin A-induced autophagy in vitro and in vivo promotes porcine circovirus type 2 replication publication-title: Cell Death Dis. doi: 10.1038/cddis.2017.303 – volume: 149 start-page: 16 year: 2018 ident: 10.1016/j.freeradbiomed.2018.12.008_bib19 article-title: APOBEC3B edits HBV DNA and inhibits HBV replication during reverse transcription publication-title: Antivir. Res. doi: 10.1016/j.antiviral.2017.11.006 – year: 2018 ident: 10.1016/j.freeradbiomed.2018.12.008_bib12 article-title: An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia publication-title: J. Clin. Investig. – volume: 75 start-page: 1104 issue: 3 year: 2001 ident: 10.1016/j.freeradbiomed.2018.12.008_bib15 article-title: Hepatitis B virus (HBV) virion and covalently closed circular DNA formation in primary tupaia hepatocytes and human hepatoma cell lines upon HBV genome transduction with replication-defective adenovirus vectors publication-title: J. Virol. doi: 10.1128/JVI.75.3.1104-1116.2001 – volume: 13 start-page: e0197109 issue: 5 year: 2018 ident: 10.1016/j.freeradbiomed.2018.12.008_bib45 article-title: HBV subgenotypes F1b and F4 replication induces an incomplete autophagic process in hepatocytes: role of BCP and preCore mutations publication-title: PLoS One doi: 10.1371/journal.pone.0197109 – volume: 37 start-page: 1320 issue: 6 year: 2003 ident: 10.1016/j.freeradbiomed.2018.12.008_bib11 article-title: Steroid-free chemotherapy decreases risk of hepatitis B virus (HBV) reactivation in HBV-carriers with lymphoma publication-title: Hepatology doi: 10.1053/jhep.2003.50220 – volume: 1 start-page: 185 issue: 2 year: 2009 ident: 10.1016/j.freeradbiomed.2018.12.008_bib4 article-title: HBV life cycle: entry and morphogenesis publication-title: Viruses doi: 10.3390/v1020185 – volume: 16 start-page: 969 issue: 7 year: 2011 ident: 10.1016/j.freeradbiomed.2018.12.008_bib9 article-title: Risk of HBV reactivation according to viral status and treatment intensity in patients with hepatocellular carcinoma publication-title: Antivir. Ther. doi: 10.3851/IMP1840 – volume: 10 start-page: 416 issue: 3 year: 2014 ident: 10.1016/j.freeradbiomed.2018.12.008_bib46 article-title: Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation publication-title: Autophagy doi: 10.4161/auto.27286 – volume: 12 start-page: 823 issue: 9 year: 2010 ident: 10.1016/j.freeradbiomed.2018.12.008_bib28 article-title: Autophagy in mammalian development and differentiation publication-title: Nat. Cell Biol. doi: 10.1038/ncb0910-823 – volume: 10 start-page: 211 issue: 3 year: 2000 ident: 10.1016/j.freeradbiomed.2018.12.008_bib1 article-title: Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) publication-title: Semin. Cancer Biol. doi: 10.1006/scbi.2000.0321 |
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| Title | Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway |
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