Morphometric Similarity Patterning of Amyloid-β and Tau Proteins Correlates with Transcriptomics in the Alzheimer’s Disease Continuum

Bridging the gap between cortical morphometric remodeling and gene expression can help to clarify the effects of the selective brain accumulation of Amyloid-β (Aβ) and tau proteins occurring in the Alzheimer’s disease (AD). To this aim, we derived morphometric similarity (MS) networks from 126 Aβ- a...

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Veröffentlicht in:	International journal of molecular sciences Jg. 25; H. 23; S. 12871
Hauptverfasser:	Brusini, Lorenza, Dolci, Giorgio, Pini, Lorenzo, Cruciani, Federica, Pizzagalli, Fabrizio, Provero, Paolo, Menegaz, Gloria, Boscolo Galazzo, Ilaria
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland MDPI AG 01.12.2024
Schlagworte:	Advertising executives Aged Aged, 80 and over Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Brain Brain - metabolism Brain - pathology Development and progression Diseases Female Gene expression Gene Expression Profiling Genes Genetic aspects Genomics Humans Italy Kinases Magnetic resonance imaging Male Proteins tau Proteins - genetics tau Proteins - metabolism Tissues Transcriptome Italy ADNI diffusion MRI T1-weighted MRI partial least squares gene expression enrichment analysis
ISSN:	1422-0067, 1661-6596, 1422-0067
Online-Zugang:	Volltext
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