Effective Reduction in Nuclear DNA Contamination Allows Sensitive Mitochondrial DNA Methylation Determination by LC-MS/MS

Mitochondria are essential organelles for cellular energy production, playing a central role in driving metabolic processes and supporting critical intracellular functions. Neurometabolic disorders encompass a wide variety of conditions characterized by mitochondrial dysfunction. Owing to their bact...

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Veröffentlicht in:	International journal of molecular sciences Jg. 26; H. 18; S. 8864
Hauptverfasser:	Liang, Lin, González Molina, Luis Alfonso, Jellema, Pytrick G., van Faassen, Martijn, Otten, Laura T. A., Mennega, Kevin P., Hof, Ingrid H., Dijck-Brouwer, D. A. Janneke, Dolga, Amalia M., Rots, Marianne G., Niezen-Koning, Klary E.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland MDPI AG 11.09.2025
Schlagworte:	Analysis Animals Cell Nucleus - genetics Cells Chromatography, Liquid - methods Circular DNA Contamination DNA Contamination DNA Methylation DNA, Mitochondrial - genetics Ethylenediaminetetraacetic acid Genetic engineering Genetic research Genomes Genomics Humans Liquid Chromatography-Mass Spectrometry Mass spectrometry Metabolic disorders Methylation Methyltransferases Mice Mitochondria Mitochondria - genetics Mitochondrial DNA Mutation Neurodegeneration RNA Scientific imaging Sulfites Tandem Mass Spectrometry - methods Netherlands United States Massachusetts Germany LC-MS/MS nuclear DNA TRIzol RNA phase mitochondrial DNA methylation neurometabolic disorders
ISSN:	1422-0067, 1661-6596, 1422-0067
Online-Zugang:	Volltext
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