International reproducibility of single breathhold T2 MR for cardiac and liver iron assessment among five thalassemia centers

Purpose: To examine the reproducibility of the single breathhold T2* technique from different scanners, after installation of standard methodology in five international centers. Materials and Methods: Up to 10 patients from each center were scanned twice locally for local interstudy reproducibility...

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Veröffentlicht in:Journal of magnetic resonance imaging Jg. 32; H. 2; S. 315 - 319
Hauptverfasser: Kirk, Paul, He, Taigang, Anderson, Lisa J., Roughton, Michael, Tanner, Mark A., Lam, Wynnie W.M., Au, Wing Y., Chu, Winnie C.W., Chan, Godfrey, Galanello, Renzo, Matta, Gildo, Fogel, Mark, Cohen, Alan R., Tan, Ru San, Chen, Kevin, Ng, Ivy, Lai, Angie, Fucharoen, Suthat, Laothamata, Jiraporn, Chuncharunee, Suporn, Jongjirasiri, Sutipong, Firmin, David N., Smith, Gillian C., Pennell, Dudley J.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.08.2010
Schlagworte:
Adult
cardiac siderosis
cardiomyopathy
cardiovascular MR
Female
Humans
Iron - metabolism
Iron Overload - pathology
Liver - pathology
Magnetic Resonance Imaging - methods
Male
Myocardium - pathology
Observer Variation
Reference Values
Reproducibility of Results
thalassemia
Thalassemia - blood
ISSN:1053-1807, 1522-2586, 1522-2586
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Zusammenfassung:Purpose: To examine the reproducibility of the single breathhold T2* technique from different scanners, after installation of standard methodology in five international centers. Materials and Methods: Up to 10 patients from each center were scanned twice locally for local interstudy reproducibility of heart and liver T2*, and then flown to a central MR facility to be rescanned on a reference scanner for intercenter reproducibility. Interobserver reproducibility for all scans was also assessed. Results: Of the 49 patients scanned, the intercenter reproducibility for T2* was 5.9% for the heart and 5.8% for the liver. Local interstudy reproducibility for T2* was 7.4% for the heart and 4.6% for the liver. Interobserver reproducibility for T2* was 5.4% for the heart and 4.4% for the liver. Conclusion: These data indicate that T2* MR may be developed into a widespread test for tissue siderosis providing that well‐defined and approved imaging and analysis techniques are used. J. Magn. Reson. Imaging 2010;32:315–319. © 2010 Wiley‐Liss, Inc.
Bibliographie:National Institutes of Health - No. 5 R01 DK066084-02
istex:6C83EFFED49E10FB25CC79FCECC0E6B4C04F77E0
ark:/67375/WNG-W1FWZHVW-H
ArticleID:JMRI22245
This work was also supported by the National Institutes of Health Research Biomedical Research Unit of Royal Brompton Hospital and Imperial College.
Registered with Clinical Trials.gov - No. NCT00520559
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ISSN:1053-1807
1522-2586
1522-2586
DOI:10.1002/jmri.22245