Agreement between self‐reported and registry‐based use of sleep medications and tranquilizers

Purpose The purpose of the present study was to assess the agreement between self‐reported use of sleep medications and tranquilizers and dispensed hypnotics and anxiolytics. Methods Self‐reported medication use was obtained from the population‐based survey Health and Environment in Oslo (HELMILO) (...

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Vydáno v:Pharmacoepidemiology and drug safety Ročník 28; číslo 10; s. 1336 - 1343
Hlavní autoři: Evandt, Jorunn, Skurtveit, Svetlana, Oftedal, Bente, Krog, Norun Hjertager, Nafstad, Per, Skovlund, Eva, Schwarze, Per E., Aasvang, Gunn Marit
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Wiley Subscription Services, Inc 01.10.2019
Témata:
Agreements
Anxiolytics
epidemiologic studies
Epidemiology
Hypnotics
hypnotics and sedatives
pharmacoepidemiology
psychotropic drugs
registries
Self report
Sleep
Tranquilizers
tranquilizing agents
self-report
epidemiologic studies
hypnotics and sedatives
registries
tranquilizing agents
psychotropic drugs
pharmacoepidemiology
ISSN:1053-8569, 1099-1557, 1099-1557
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Shrnutí:Purpose The purpose of the present study was to assess the agreement between self‐reported use of sleep medications and tranquilizers and dispensed hypnotics and anxiolytics. Methods Self‐reported medication use was obtained from the population‐based survey Health and Environment in Oslo (HELMILO) (2009‐2010) (n = 13 019). Data on dispensed hypnotics and anxiolytics were obtained from the Norwegian Prescription Database (NorPD). As measures of validity, we calculated sensitivity and specificity using both self‐reports and prescription records as the reference standard. Furthermore, we calculated Cohen's kappa. Current self‐reported medication use was compared with prescription data in time windows of both 100 and 200 days preceding questionnaire completion. Results The highest sensitivity was observed for current sleep medication use in the 100‐day time window (sensitivity = 0.76, 95% confidence interval [CI]: 0.74, 0.79) when using prescription records as the reference standard. Sensitivity was generally lower for tranquilizers compared with sleep medications. Cohen's kappa showed the highest agreement for the 200‐day time window with substantial agreement for sleep medications (kappa = 0.64; 95% CI: 0.62, 0.67) and moderate agreement for tranquilizers (kappa = 0.45; 95% CI: 0.41, 0.48). Conclusions The present study suggests moderate to substantial agreement between self‐reported use of sleep medications and tranquilizers and dispensed drugs in a general adult population. The magnitude of agreement varied according to drug category and time window. Since self‐reported and registry‐based use of these drug classes does not match each other accurately, limitations of each data source should be considered when such medications are applied as the exposure or outcome in epidemiologic studies.
Bibliografie:ObjectType-Article-1
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ISSN:1053-8569
1099-1557
1099-1557
DOI:10.1002/pds.4854