Acute-on-Chronic Liver Failure Clinical Guidelines

In patients with cirrhosis and chronic liver disease, acute-on-chronic liver failure is emerging as a major cause of mortality. These guidelines indicate the preferred approach to the management of patients with acute-on-chronic liver failure and represent the official practice recommendations of th...

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Bibliographic Details
Published in:The American journal of gastroenterology Vol. 117; no. 2; pp. 225 - 252
Main Authors: Bajaj, Jasmohan S., O'Leary, Jacqueline G., Lai, Jennifer C., Wong, Florence, Long, Millie D., Wong, Robert J., Kamath, Patrick S.
Format: Journal Article
Language:English
Published: United States Wolters Kluwer 01.02.2022
Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
Subjects:
Acute-On-Chronic Liver Failure - epidemiology
Acute-On-Chronic Liver Failure - therapy
Alcohol
Ascites
Consensus
Disease Management
Gastroenterology
Global Health
Hepatitis
Humans
Intensive care
Liver cirrhosis
Liver diseases
Liver failure
Morbidity - trends
Mortality
Palliative care
Pathophysiology
Patients
Practice Guidelines as Topic
Societies, Medical
Survival Rate - trends
ISSN:0002-9270, 1572-0241, 1572-0241
Online Access:Get full text
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Summary:In patients with cirrhosis and chronic liver disease, acute-on-chronic liver failure is emerging as a major cause of mortality. These guidelines indicate the preferred approach to the management of patients with acute-on-chronic liver failure and represent the official practice recommendations of the American College of Gastroenterology. The scientific evidence for these guidelines was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation process. In instances where the evidence was not appropriate for Grading of Recommendations, Assessment, Development, and Evaluation, but there was consensus of significant clinical merit, key concept statements were developed using expert consensus. These guidelines are meant to be broadly applicable and should be viewed as the preferred, but not only, approach to clinical scenarios.
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ISSN:0002-9270
1572-0241
1572-0241
DOI:10.14309/ajg.0000000000001595