Comparative Oral Absorption of Curcumin in a Natural Turmeric Matrix with Two Other Curcumin Formulations: An Open‐label Parallel‐arm Study

Curcuminoids are the major bioactive molecules in turmeric, and poor bioavailability deters them from being the major components of many health and wellness applications. This study was conducted to assess the bioavailability of a completely natural turmeric matrix formulation (CNTMF) and compare it...

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Veröffentlicht in:Phytotherapy research Jg. 31; H. 12; S. 1883 - 1891
Hauptverfasser: Gopi, Sreeraj, Jacob, Joby, Varma, Karthik, Jude, Shintu, Amalraj, Augustine, Arundhathy, C.A., George, Robin, Sreeraj, T.R., Divya, C., Kunnumakkara, Ajaikumar B., Stohs, Sidney J.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Wiley Subscription Services, Inc 01.12.2017
Schlagworte:
Absorption
Administration, Oral
Adolescent
Adult
bioactive compounds
Bioavailability
Biological Availability
Blood
blood plasma absorption
blood sampling
Cellulose
clinical trial
completely natural turmeric matrix
Curcuma - chemistry
Curcumin
Curcumin - chemistry
curcumin formulations
Formulations
Humans
Ingestion
Liquid chromatography
Male
males
Mass spectrometry
Mass spectroscopy
Middle Aged
Oil
oils
phospholipid
Phospholipids
turmeric
turmeric oil
Young Adult
clinical trial
phospholipid
turmeric oil
completely natural turmeric matrix
curcumin formulations
blood plasma absorption
ISSN:0951-418X, 1099-1573, 1099-1573
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Zusammenfassung:Curcuminoids are the major bioactive molecules in turmeric, and poor bioavailability deters them from being the major components of many health and wellness applications. This study was conducted to assess the bioavailability of a completely natural turmeric matrix formulation (CNTMF) and compare its bioavailability with two other commercially available formulations, namely, curcumin with volatile oil (volatile oil formulation) and curcumin with phospholipids and cellulose (phospholipid formulation) in healthy human adult male subjects (15 each group) under fasting conditions. Each formulation was administrated orally as a single 500‐mg dose in capsule form, and blood samples were analyzed by liquid chromatography mass spectrometry at various time intervals up to 24 h. The ingestion of the CNTMF was very well absorbed and resulted in a mean curcuminoids plasma Cmax of 170.14 ng/mL (Tmax = 4 h) compared with 47.54 ng/mL and 69.63 ng/mL for the volatile oil (Tmax = 3 h) and phospholipid (Tmax = 2.25 h) formulations, respectively. The extent of absorption of total curcuminoids in the blood for the CNTMF was 6× greater than volatile oil formulation and 5× greater than phospholipids formulation. The results of this study indicate that curcumin in a natural turmeric matrix exhibited greater bioavailability than the two comparator products. Copyright © 2017 John Wiley & Sons, Ltd.
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ISSN:0951-418X
1099-1573
1099-1573
DOI:10.1002/ptr.5931